2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  3. FAK Akt mTOR
  4. Ovalitenone

Ovalitenone is a flavonoid compound that can be isolated from the plant Millettia peguensis. It shows no cytotoxic effects on lung cancer H460 and A549 cells, but it significantly inhibits anchorage-independent growth, CSC-like phenotypes, colony formation, and the migration and invasion capabilities of cancer cells. Ovalitenone can significantly reduce the levels of N-cadherin, snail, and slug, while increasing E-cadherin, thus inhibiting the EMT pathway. Additionally, Ovalitenone suppresses the signaling pathways regulated by focal adhesion kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42).

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Ovalitenone Chemical Structure

Ovalitenone Chemical Structure

CAS No. : 64280-22-4

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Ovalitenone Related Antibodies

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Description

Ovalitenone is a flavonoid compound that can be isolated from the plant Millettia peguensis. It shows no cytotoxic effects on lung cancer H460 and A549 cells, but it significantly inhibits anchorage-independent growth, CSC-like phenotypes, colony formation, and the migration and invasion capabilities of cancer cells. Ovalitenone can significantly reduce the levels of N-cadherin, snail, and slug, while increasing E-cadherin, thus inhibiting the EMT pathway. Additionally, Ovalitenone suppresses the signaling pathways regulated by focal adhesion kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42)[1][2].

Molecular Weight

338.31

Formula

C19H14O6
CAS No.
SMILES

O=C(CC(C1=CC=C2OC=CC2=C1OC)=O)C3=CC=C4OCOC4=C3
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Ovalitenone Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ovalitenone64280-22-4FAKAktmTORPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasePKBProtein kinase BMammalian target of RapamycinATP-dependent tyrosine kinaseMillettia peguensisH460A549Inhibitorinhibitorinhibit

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