Top1 - DNA topoisomerase I Gene

Rattus norvegicus

Also known as Ab2-086

Gene ID: 64550 | Gene type: protein coding

About Top1

Primary_assembly 3: 149,293,403-149,376,623 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 273 orthologues, 1 paralogue and is associated with 7 phenotypes. Biased expression in Spleen (RPKM 242.9), Thymus (RPKM 228.2) and 9 other tissues.

Summary

Enables DNA Topoisomerase type I (single strand cut, ATP-independent) activity and chromatin DNA binding activity. Involved in several processes, including cellular response to luteinizing hormone stimulus; nucleic acid metabolic process; and response to gamma radiation. Located in dense fibrillar component and fibrillar center. Orthologous to human TOP1 (DNA Topoisomerase I). [provided by Alliance of Genome Resources, Apr 2022]

Top1 Products(1)

mRNA	Protein	Name
NM_022615.2	NP_072137.1	DNA topoisomerase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10469141	RGD
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA IDA: Inferred from direct assay	1332866	RGD
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	1332866	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	2851418	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA topological change	IDA IDA: Inferred from direct assay	1332866	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	1332866	RGD
involved in cellular response to luteinizing hormone stimulus	IEP IEP: Inferred from expression pattern	2822514	RGD
involved in rRNA transcription	IMP IMP: Inferred from mutant phenotype	3033639	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	2822514	RGD
involved in response to gamma radiation	IEP IEP: Inferred from expression pattern	2853856	RGD
involved in response to temperature stimulus	IEP IEP: Inferred from expression pattern	9076473	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dense fibrillar component	IDA IDA: Inferred from direct assay	11170002	RGD
located in fibrillar center	IDA IDA: Inferred from direct assay	17587596	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Top1 Protein Structure

Topoisomer_IB_N_htopoI_like

TOPEUc

0
200
400
600
767 a.a.

Protein Preferred Names

Protein Names

DNA topoisomerase 1

topoisomerase (DNA) I

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16560	Camptothecin		99.86%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-U00248A	LMP744 hydrochloride	Inhibitor	99.70%	Phase 1
HY-U00248	LMP744	Inhibitor	98.85%	Phase 1

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0114A	(±)-Evodiamine		99.74%	Unkown
HY-18350	Indimitecan	Inhibitor	98.03%	Unkown
HY-160005	LMP517	Inhibitor	99.58%	Unkown
HY-P10742	CBX-12	Inhibitor	/	Unkown
HY-126142	Top1 inhibitor 1	Inhibitor	/	Unkown
HY-143265	Topoisomerase I inhibitor 2		/	Unkown
HY-144794	EGFR-IN-46		/	Unkown
HY-146437	Topoisomerase I inhibitor 6	Inhibitor	/	Unkown
HY-149348	DiPT-4		/	Unkown
HY-161957	Top1/2-IN-1	Inhibitor	/	Unkown
HY-168739	Topoisomerase I inhibitor 17		/	Unkown
HY-18350A	Indimitecan hydrochloride	Inhibitor	/	Unkown
HY-RS14890	TOP1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS14891	Top1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS14892	Top1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS14893	TOP1MT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-118942	Topovale	Inhibitor	/	Unkown
HY-133219	Guajadial C	Inhibitor	/	Unkown
HY-164429	VIP236		/	Unkown
HY-16560B	(R)-Camptothecin		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Top1	NCBI	NCBI:7150

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