2. Gene
  3. TNS3 - tensin 3 Gene

TNS3 - tensin 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TEM6; TENS1

Gene ID: 64759 | Gene type: protein coding

About TNS3

Cytogenetic location: 7p12.3 Genomic coordinates (GRCh38): 7:47,275,154-47,582,586 (from NCBI)

This gene has 15 transcripts (splice variants), 280 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 15.0), lung (RPKM 14.4) and 25 other tissues.

Summary

Predicted to enable Phosphatase activity. Predicted to be involved in dephosphorylation and intracellular signal transduction. Predicted to act upstream of or within cell migration; lung alveolus development; and positive regulation of cell population proliferation. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

TNS3 Products(3)

mRNA Protein Name
NM_001410877.1 NP_001397806.1 tensin-3 isoform 1
NM_001410878.1 NP_001397807.1 tensin-3 isoform 2
NM_022748.12 NP_073585.8 tensin-3 isoform 3

TNS3 Protein Structure

PTEN_C2

PTEN_C2: C2 domain of PTEN tumour-suppressor protein (174 - 299)

SH2

SH2: SH2 domain (1172 - 1265)

PTB

PTB: Phosphotyrosine-binding domain (1310 - 1444)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1445 a.a.
Protein Preferred Names Protein Names

tensin-3

tensin-like SH2 domain containing 1

Related Diseases

Diseases Alias
Thyroid Tumor
Primary Syphilis

Early Symptomatic Syphilis

Early Syphilis, Symptomatic

Symptomatic Early Syphilis
Scoliosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14869 TNS3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TNS3 VGNC VGNC:79324
Bos taurus TNS3 VGNC VGNC:36209
Canis familiaris TNS3 VGNC VGNC:51833
Felis catus TNS3 VGNC VGNC:66437
Rattus norvegicus TNS3 RGD RGD:1564174
Mus musculus TNS3 MGD MGI:2443012