2. Gene
  3. MTMR9 - myotubularin related protein 9 Gene

MTMR9 - myotubularin related protein 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MTMR8; C8orf9; LIP-STYX

Gene ID: 66036 | Gene type: protein coding

About MTMR9

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:11,284,816-11,339,526 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 220 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 9.7), testis (RPKM 6.0) and 23 other tissues.

Summary

This gene encodes a myotubularin-related protein that is atypical to most Other members of the myotubularin-related protein family because it has no dual-specificity Phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. [provided by RefSeq, Jul 2008]

MTMR9 Products(1)

mRNA Protein Name
NM_015458.4 NP_056273.2 myotubularin-related protein 9

MTMR9 Protein Structure

Myotub-related

Myotub-related: Myotubularin-like phosphatase domain (108 - 447)

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  • 549 a.a.
Protein Preferred Names Protein Names

myotubularin-related protein 9

inactive phosphatidylinositol 3-phosphatase 9

MTMR9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MTMR9 Q96QG7 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
32296183
Intra
MTMR9 Q96QG7 MTMR7 Homo sapiens Q9Y216
Anti Tag CoIP
28514442
Intra
MTMR9 Q96QG7 MTMR7 Homo sapiens Q9Y216
Y2H Array
31515488
Intra
MTMR9 Q96QG7 MTMR7 Homo sapiens Q9Y216
Anti Tag CoIP
27880917
Intra
MTMR9 Q96QG7 MTMR7 Homo sapiens Q9Y216
Validated Y2H
32296183
Intra
MTMR9 Q96QG7 PTPN3 Homo sapiens P26045
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 PTPN3 Homo sapiens P26045
Y2H Array
32296183
Intra
MTMR9 Q96QG7 GRAMD4 Homo sapiens Q6IC98
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 GRAMD4 Homo sapiens Q6IC98
Y2H Array
32296183
Intra
MTMR9 Q96QG7 EMILIN1 Homo sapiens Q9Y6C2-2
Validated Y2H
32296183
Intra
MTMR9 Q96QG7 EMILIN1 Homo sapiens Q9Y6C2-2
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 EMILIN1 Homo sapiens Q9Y6C2-2
Y2H Array
32296183
Intra
MTMR9 Q96QG7 FAM169A Homo sapiens Q9Y6X4
Validated Y2H
32296183
Intra
MTMR9 Q96QG7 DEPDC5 Homo sapiens O75140-2
Y2H Array
32296183
Intra
MTMR9 Q96QG7 DEPDC5 Homo sapiens O75140-2
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 MOS Homo sapiens P00540
Y2H Array
31515488
Intra
MTMR9 Q96QG7 MOS Homo sapiens P00540
Y2H Prey Pooling
25416956
Intra
MTMR9 Q96QG7 MOS Homo sapiens P00540
Validated Y2H
25416956
Intra
MTMR9 Q96QG7 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra
MTMR9 Q96QG7 VAC14 Homo sapiens Q08AM6
Y2H Array
25416956
Intra
MTMR9 Q96QG7 VAC14 Homo sapiens Q08AM6
Validated Y2H
25416956
Intra
MTMR9 Q96QG7 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
MTMR9 Q96QG7 KIAA1328 Homo sapiens Q86T90
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 KIAA1328 Homo sapiens Q86T90
Y2H Array
32296183
Intra
MTMR9 Q96QG7 NMI Homo sapiens Q13287
Y2H Array
25416956
Intra
MTMR9 Q96QG7 NMI Homo sapiens Q13287
Y2H Array
32296183
Intra
MTMR9 Q96QG7 NMI Homo sapiens Q13287
Y2H Prey Pooling
25416956
Intra
MTMR9 Q96QG7 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
MTMR9 Q96QG7 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
MTMR9 Q96QG7 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
MTMR9 Q96QG7 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
MTMR9 Q96QG7 EMILIN1 Homo sapiens Q9Y6C2
Y2H Array
25416956
Intra
MTMR9 Q96QG7 EMILIN1 Homo sapiens Q9Y6C2
Y2H Prey Pooling
25416956
Intra
MTMR9 Q96QG7 EMILIN1 Homo sapiens Q9Y6C2
Validated Y2H
25416956
Intra
MTMR9 Q96QG7 MTMR8 Homo sapiens Q96EF0
Anti Tag CoIP
27880917
Intra
MTMR9 Q96QG7 MTMR8 Homo sapiens Q96EF0
Y2H Pooling
16189514
Intra
MTMR9 Q96QG7 MTMR8 Homo sapiens Q96EF0
Anti Tag CoIP
33961781
Intra
MTMR9 Q96QG7 MTMR8 Homo sapiens Q96EF0
Anti Tag CoIP
28514442
Intra
MTMR9 Q96QG7 MTMR6 Homo sapiens Q9Y217
Anti Tag CoIP
27880917
Intra
MTMR9 Q96QG7 MTMR6 Homo sapiens Q9Y217
Y2H Prey Pooling
32296183
Intra
MTMR9 Q96QG7 MTMR6 Homo sapiens Q9Y217
Validated Y2H
32296183
Intra
MTMR9 Q96QG7 MTMR6 Homo sapiens Q9Y217
Y2H Array
25416956
Intra
MTMR9 Q96QG7 MTMR6 Homo sapiens Q9Y217
Y2H Array
32296183
Intra
MTMR9 Q96QG7 MTMR6 Homo sapiens Q9Y217
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Keratolytic Winter Erythema

KWE

Oudtshoorn Skin Disease

Erythrokeratolysis Hiemalis Ichthyosis

Erythrokeratolysis Hiemalis

Oudtshoorn Skin

Oudtshoorn Disease
Osteopathia Striata With Cranial Sclerosis

Hyperostosis Generalisata With Striations

Robinow-Unger Syndrome

OSCS

Osteopathia Striata Cranial Sclerosis

Osteopathia Striata-Cranial Sclerosis Syndrome

Horan-Beighton Syndrome

Os-Cs

Osteopathia Striata - Cranial Sclerosis

Voorhoeve Disease

Osc
Myopathy, Centronuclear, X-Linked

X-Linked Myotubular Myopathy

Xlmtm

X-Linked Centronuclear Myopathy

Xlcnm

CNMX

Mtm1

Myotubular Myopathy, X-Linked

Mtmx

Myotubular Myopathy 1

Centronuclear Myopathy X-Linked

Myotubular Myopathy

Mtm

Cnm

Xmtm

Myotubular Myopathy Type 1
Centronuclear Myopathy

Myopathy, Centronuclear

Myotubular Myopathy

Cnm

Myopathy, Myotubular

Congenital Structural Myopathy
Generalized Epilepsy With Febrile Seizures Plus

Gefs+

Genetic Epilepsy With Febrile Seizures Plus

Generalized Epilepsy With Febrile Seizures-Plus

Genetic Epilepsy With Febrile Seizures-Plus

Epilepsy, Generalized, With Febrile Seizures Plus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08795 MTMR9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MTMR9 VGNC VGNC:43488
Macaca mulatta MTMR9 VGNC VGNC:74957
Bos taurus MTMR9 VGNC VGNC:50009
Mus musculus MTMR9 MGD MGI:2442842
Rattus norvegicus MTMR9 RGD RGD:628840
Felis catus MTMR9 VGNC VGNC:63656