MOS - MOS proto-oncogene, serine/threonine kinase Gene

Homo sapiens

Also known as MSV

Gene ID: 4342 | Gene type: protein coding

About MOS

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:56,112,942-56,113,982 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues and 23 paralogues.

Summary

MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

MOS Products(1)

mRNA	Protein	Name
NM_005372.1	NP_005363.1	proto-oncogene serine/threonine-protein kinase mos

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in oocyte maturation	IMP IMP: Inferred from mutant phenotype	34779126	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	34779126	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	35670744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOS Protein Structure

Pkinase

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

proto-oncogene serine/threonine-protein kinase mos

c-mos

MOS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MOS	P00540	CCDC136	Homo sapiens	Q96JN2-2	Validated Y2H	25416956
Intra	MOS	P00540	KRT13	Homo sapiens	A1A4E9	Y2H Array	25416956
Intra	MOS	P00540	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
Intra	MOS	P00540	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	MOS	P00540	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	25416956
Intra	MOS	P00540	BORCS6	Homo sapiens	Q96GS4	Validated Y2H	25416956
Intra	MOS	P00540	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	MOS	P00540	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	MOS	P00540	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	MOS	P00540	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	MOS	P00540	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	MOS	P00540	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	MOS	P00540	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	MOS	P00540	MAP2K2	Homo sapiens	P36507	Y2H Array	32296183
Intra	MOS	P00540	MAP2K2	Homo sapiens	P36507	Y2H Prey Pooling	32296183
Intra	MOS	P00540	MAP2K2	Homo sapiens	P36507	Validated Y2H	32296183
Intra	MOS	P00540	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	MOS	P00540	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	MOS	P00540	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	MOS	P00540	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	MOS	P00540	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	MOS	P00540	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	MOS	P00540	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	MOS	P00540	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	30886144
Intra	MOS	P00540	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	MOS	P00540	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	MOS	P00540	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	MOS	P00540	CBY2	Homo sapiens	Q8NA61-2	Validated Y2H	32296183
Intra	MOS	P00540	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	MOS	P00540	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	MOS	P00540	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	MOS	P00540	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	MOS	P00540	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	MOS	P00540	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	MOS	P00540	BICD2	Homo sapiens	Q8TD16-2	Y2H Prey Pooling	32296183
Intra	MOS	P00540	BICD2	Homo sapiens	Q8TD16-2	Validated Y2H	32296183
Intra	MOS	P00540	BICD2	Homo sapiens	Q8TD16-2	Y2H Array	32296183
Intra	MOS	P00540	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	MOS	P00540	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	MOS	P00540	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	MOS	P00540	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	MOS	P00540	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	MOS	P00540	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	MOS	P00540	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	MOS	P00540	NOTCH2NLC	Homo sapiens	P0DPK4	Validated Y2H	32296183
Intra	MOS	P00540	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	MOS	P00540	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	32296183
Intra	MOS	P00540	KCTD6	Homo sapiens	Q8NC69	Y2H Array	32296183
Intra	MOS	P00540	KCTD6	Homo sapiens	Q8NC69	Y2H Prey Pooling	32296183
Intra	MOS	P00540	ZBTB2	Homo sapiens	Q8N680	Y2H Array	32296183
Intra	MOS	P00540	ZBTB2	Homo sapiens	Q8N680	Y2H Prey Pooling	32296183
Intra	MOS	P00540	ZBTB2	Homo sapiens	Q8N680	Validated Y2H	32296183
Intra	MOS	P00540	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	32296183
Intra	MOS	P00540	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	32296183
Intra	MOS	P00540	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	32296183
Intra	MOS	P00540	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	MOS	P00540	HSP90AA1	Homo sapiens	P07900	Pull Down	32707033
Intra	MOS	P00540	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	MOS	P00540	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	MOS	P00540	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	MOS	P00540	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	33961781
Intra	MOS	P00540	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	28514442
Intra	MOS	P00540	FKBP5	Homo sapiens	Q13451	Lumier	25036637
Intra	MOS	P00540	FKBP5	Homo sapiens	Q13451	Pull Down	32707033
Intra	MOS	P00540	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	MOS	P00540	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	MOS	P00540	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	MOS	P00540	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	MOS	P00540	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	MOS	P00540	STUB1	Homo sapiens	Q9UNE7	Pull Down	32707033
Intra	MOS	P00540	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	MOS	P00540	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	MOS	P00540	TRAF1	Homo sapiens	Q13077	Validated Y2H	32296183
Intra	MOS	P00540	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	MOS	P00540	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	MOS	P00540	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	MOS	P00540	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	MOS	P00540	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	MOS	P00540	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	MOS	P00540	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	MOS	P00540	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	MOS	P00540	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	MOS	P00540	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	MOS	P00540	PPP2R5A	Homo sapiens	Q15172	Pull Down	32707033
Intra	MOS	P00540	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	28514442
Intra	MOS	P00540	PPP2R5A	Homo sapiens	Q15172	Y2H Prey Pooling	32296183
Intra	MOS	P00540	PPP2R5A	Homo sapiens	Q15172	Validated Y2H	32296183
Intra	MOS	P00540	PPP2R5A	Homo sapiens	Q15172	Y2H Array	32296183
Intra	MOS	P00540	ASB6	Homo sapiens	Q9NWX5	Y2H Prey Pooling	32296183
Intra	MOS	P00540	ASB6	Homo sapiens	Q9NWX5	Validated Y2H	32296183
Intra	MOS	P00540	ASB6	Homo sapiens	Q9NWX5	Y2H Array	32296183
Intra	MOS	P00540	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	MOS	P00540	KRT15	Homo sapiens	P19012	Validated Y2H	25416956
Intra	MOS	P00540	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	MOS	P00540	KRT15	Homo sapiens	P19012	Validated Y2H	32296183
Intra	MOS	P00540	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	MOS	P00540	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	MOS	P00540	CALCOCO2	Homo sapiens	Q13137	Y2H Array	31515488
Intra	MOS	P00540	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	MOS	P00540	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	32296183
Intra	MOS	P00540	CALCOCO2	Homo sapiens	Q13137	Y2H Array	32296183
Intra	MOS	P00540	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	MOS	P00540	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	32296183
Intra	MOS	P00540	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	MOS	P00540	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	MOS	P00540	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	MOS	P00540	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	MOS	P00540	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	25416956
Intra	MOS	P00540	GRAP2	Homo sapiens	O75791	Y2H Array	32296183
Intra	MOS	P00540	GRAP2	Homo sapiens	O75791	Y2H Prey Pooling	32296183
Intra	MOS	P00540	DYDC1	Homo sapiens	Q8WWB3	Validated Y2H	25416956
Intra	MOS	P00540	DYDC1	Homo sapiens	Q8WWB3	Y2H Array	25416956
Intra	MOS	P00540	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	MOS	P00540	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	MOS	P00540	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	MOS	P00540	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	MOS	P00540	CBY2	Homo sapiens	Q8NA61	Y2H Prey Pooling	25416956
Intra	MOS	P00540	GFAP	Homo sapiens	P14136	Y2H Prey Pooling	25416956
Intra	MOS	P00540	MTMR9	Homo sapiens	Q96QG7	Y2H Array	31515488
Intra	MOS	P00540	MTMR9	Homo sapiens	Q96QG7	Y2H Array	25416956
Intra	MOS	P00540	MTMR9	Homo sapiens	Q96QG7	Y2H Array	29892012
Intra	MOS	P00540	ATRIP	Homo sapiens	Q8WXE1	Y2H Array	25416956
Intra	MOS	P00540	ATRIP	Homo sapiens	Q8WXE1	Y2H Prey Pooling	25416956
Intra	MOS	P00540	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	MOS	P00540	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	25416956
Intra	MOS	P00540	HOMER3	Homo sapiens	Q9NSC5	Complementation	32296183
Intra	MOS	P00540	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	MOS	P00540	HOMER3	Homo sapiens	Q9NSC5	Y2H	21516116
Intra	MOS	P00540	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	25416956
Intra	MOS	P00540	ACTN2	Homo sapiens	P35609	Y2H Array	25416956
Intra	MOS	P00540	ACTN2	Homo sapiens	P35609	Validated Y2H	25416956
Intra	MOS	P00540	ACTN2	Homo sapiens	P35609	Y2H Prey Pooling	25416956
Intra	MOS	P00540	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	MOS	P00540	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	MOS	P00540	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	MOS	P00540	SEC24C	Homo sapiens	P53992	Y2H Prey Pooling	25416956
Intra	MOS	P00540	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	MOS	P00540	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	MOS	P00540	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	MOS	P00540	KIFAP3	Homo sapiens	Q92845	Validated Y2H	32296183
Intra	MOS	P00540	KIFAP3	Homo sapiens	Q92845	Y2H Array	32296183
Intra	MOS	P00540	KIFAP3	Homo sapiens	Q92845	Y2H Prey Pooling	32296183
Intra	MOS	P00540	DZIP1	Homo sapiens	Q86YF9	Y2H Prey Pooling	32296183
Intra	MOS	P00540	DZIP1	Homo sapiens	Q86YF9	Validated Y2H	32296183
Intra	MOS	P00540	DZIP1	Homo sapiens	Q86YF9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08598	MOS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MOS	VGNC	VGNC:68300
Bos taurus	MOS	VGNC	VGNC:31563
Rattus norvegicus	MOS	RGD	RGD:3103
Macaca mulatta	MOS	VGNC	VGNC:74911
Mus musculus	MOS	MGD	MGI:97052
Canis familiaris	MOS	VGNC	VGNC:43323
Macaca fascicularis	MOS	NCBI	NCBI:102119783
Others	MOS	NCBI

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