2. Gene
  3. MOS - MOS proto-oncogene, serine/threonine kinase Gene

MOS - MOS proto-oncogene, serine/threonine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MSV

Gene ID: 4342 | Gene type: protein coding

About MOS

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:56,112,942-56,113,982 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues and 23 paralogues.

Summary

MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

MOS Products(1)

mRNA Protein Name
NM_005372.1 NP_005363.1 proto-oncogene serine/threonine-protein kinase mos
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
Biological Process GO Annotation Evidence Reference Source
involved in oocyte maturation IMP
IMP: Inferred from mutant phenotype
34779126 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
34779126 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
35670744 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOS Protein Structure

Pkinase

Pkinase: Protein kinase domain (62 - 335)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

proto-oncogene serine/threonine-protein kinase mos

c-mos

MOS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MOS P00540 CCDC136 Homo sapiens Q96JN2-2
Validated Y2H
25416956
Intra MOS P00540 KRT13 Homo sapiens A1A4E9
Y2H Array
25416956
Intra MOS P00540 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
Intra MOS P00540 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
25416956
Intra MOS P00540 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
25416956
Intra MOS P00540 BORCS6 Homo sapiens Q96GS4
Validated Y2H
25416956
Intra MOS P00540 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra MOS P00540 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra MOS P00540 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra MOS P00540 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra MOS P00540 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra MOS P00540 PSTPIP1 Homo sapiens O43586
Y2H Array
32296183
Intra MOS P00540 PSTPIP1 Homo sapiens O43586
Y2H Prey Pooling
32296183
Intra MOS P00540 MAP2K2 Homo sapiens P36507
Y2H Array
32296183
Intra MOS P00540 MAP2K2 Homo sapiens P36507
Y2H Prey Pooling
32296183
Intra MOS P00540 MAP2K2 Homo sapiens P36507
Validated Y2H
32296183
Intra MOS P00540 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
Intra MOS P00540 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
Intra MOS P00540 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
Intra MOS P00540 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra MOS P00540 IKZF1 Homo sapiens Q13422-7
Validated Y2H
32296183
Intra MOS P00540 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra MOS P00540 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra MOS P00540 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
30886144
Intra MOS P00540 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra MOS P00540 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra MOS P00540 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra MOS P00540 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
32296183
Intra MOS P00540 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
Intra MOS P00540 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra MOS P00540 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra MOS P00540 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra MOS P00540 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
Intra MOS P00540 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra MOS P00540 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
Intra MOS P00540 BICD2 Homo sapiens Q8TD16-2
Validated Y2H
32296183
Intra MOS P00540 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
Intra MOS P00540 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra MOS P00540 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra MOS P00540 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra MOS P00540 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra MOS P00540 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
Intra MOS P00540 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
Intra MOS P00540 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra MOS P00540 NOTCH2NLC Homo sapiens P0DPK4
Validated Y2H
32296183
Intra MOS P00540 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra MOS P00540 KCTD6 Homo sapiens Q8NC69
Validated Y2H
32296183
Intra MOS P00540 KCTD6 Homo sapiens Q8NC69
Y2H Array
32296183
Intra MOS P00540 KCTD6 Homo sapiens Q8NC69
Y2H Prey Pooling
32296183
Intra MOS P00540 ZBTB2 Homo sapiens Q8N680
Y2H Array
32296183
Intra MOS P00540 ZBTB2 Homo sapiens Q8N680
Y2H Prey Pooling
32296183
Intra MOS P00540 ZBTB2 Homo sapiens Q8N680
Validated Y2H
32296183
Intra MOS P00540 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
32296183
Intra MOS P00540 MIPOL1 Homo sapiens Q8TD10
Y2H Array
32296183
Intra MOS P00540 MIPOL1 Homo sapiens Q8TD10
Y2H Prey Pooling
32296183
Intra MOS P00540 CDC37 Homo sapiens Q16543
Pull Down
32707033
Intra MOS P00540 HSP90AA1 Homo sapiens P07900
Pull Down
32707033
Intra MOS P00540 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra MOS P00540 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra MOS P00540 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra MOS P00540 FKBP5 Homo sapiens Q13451
Anti Tag CoIP
33961781
Intra MOS P00540 FKBP5 Homo sapiens Q13451
Anti Tag CoIP
28514442
Intra MOS P00540 FKBP5 Homo sapiens Q13451
Lumier
25036637
Intra MOS P00540 FKBP5 Homo sapiens Q13451
Pull Down
32707033
Intra MOS P00540 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra MOS P00540 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra MOS P00540 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra MOS P00540 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra MOS P00540 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra MOS P00540 STUB1 Homo sapiens Q9UNE7
Pull Down
32707033
Intra MOS P00540 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra MOS P00540 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra MOS P00540 TRAF1 Homo sapiens Q13077
Validated Y2H
32296183
Intra MOS P00540 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra MOS P00540 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra MOS P00540 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra MOS P00540 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra MOS P00540 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra MOS P00540 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra MOS P00540 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra MOS P00540 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra MOS P00540 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra MOS P00540 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra MOS P00540 PPP2R5A Homo sapiens Q15172
Pull Down
32707033
Intra MOS P00540 PPP2R5A Homo sapiens Q15172
Anti Tag CoIP
28514442
Intra MOS P00540 PPP2R5A Homo sapiens Q15172
Y2H Prey Pooling
32296183
Intra MOS P00540 PPP2R5A Homo sapiens Q15172
Validated Y2H
32296183
Intra MOS P00540 PPP2R5A Homo sapiens Q15172
Y2H Array
32296183
Intra MOS P00540 ASB6 Homo sapiens Q9NWX5
Y2H Prey Pooling
32296183
Intra MOS P00540 ASB6 Homo sapiens Q9NWX5
Validated Y2H
32296183
Intra MOS P00540 ASB6 Homo sapiens Q9NWX5
Y2H Array
32296183
Intra MOS P00540 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra MOS P00540 KRT15 Homo sapiens P19012
Validated Y2H
25416956
Intra MOS P00540 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra MOS P00540 KRT15 Homo sapiens P19012
Validated Y2H
32296183
Intra MOS P00540 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra MOS P00540 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
Intra MOS P00540 CALCOCO2 Homo sapiens Q13137
Y2H Array
31515488
Intra MOS P00540 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra MOS P00540 CALCOCO2 Homo sapiens Q13137
Validated Y2H
32296183
Intra MOS P00540 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra MOS P00540 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra MOS P00540 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra MOS P00540 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra MOS P00540 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra MOS P00540 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra MOS P00540 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
Intra MOS P00540 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra MOS P00540 GRAP2 Homo sapiens O75791
Y2H Array
32296183
Intra MOS P00540 GRAP2 Homo sapiens O75791
Y2H Prey Pooling
32296183
Intra MOS P00540 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
25416956
Intra MOS P00540 DYDC1 Homo sapiens Q8WWB3
Y2H Array
25416956
Intra MOS P00540 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra MOS P00540 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra MOS P00540 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra MOS P00540 CBY2 Homo sapiens Q8NA61
Y2H Array
25416956
Intra MOS P00540 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
Intra MOS P00540 GFAP Homo sapiens P14136
Y2H Prey Pooling
25416956
Intra MOS P00540 MTMR9 Homo sapiens Q96QG7
Y2H Array
31515488
Intra MOS P00540 MTMR9 Homo sapiens Q96QG7
Y2H Array
25416956
Intra MOS P00540 MTMR9 Homo sapiens Q96QG7
Y2H Array
29892012
Intra MOS P00540 ATRIP Homo sapiens Q8WXE1
Y2H Array
25416956
Intra MOS P00540 ATRIP Homo sapiens Q8WXE1
Y2H Prey Pooling
25416956
Intra MOS P00540 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra MOS P00540 HOMER3 Homo sapiens Q9NSC5
Y2H Array
25416956
Intra MOS P00540 HOMER3 Homo sapiens Q9NSC5
Complementation
32296183
Intra MOS P00540 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra MOS P00540 HOMER3 Homo sapiens Q9NSC5
Y2H
21516116
Intra MOS P00540 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
25416956
Intra MOS P00540 ACTN2 Homo sapiens P35609
Y2H Array
25416956
Intra MOS P00540 ACTN2 Homo sapiens P35609
Validated Y2H
25416956
Intra MOS P00540 ACTN2 Homo sapiens P35609
Y2H Prey Pooling
25416956
Intra MOS P00540 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra MOS P00540 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra MOS P00540 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra MOS P00540 SEC24C Homo sapiens P53992
Y2H Prey Pooling
25416956
Intra MOS P00540 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra MOS P00540 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra MOS P00540 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra MOS P00540 KIFAP3 Homo sapiens Q92845
Validated Y2H
32296183
Intra MOS P00540 KIFAP3 Homo sapiens Q92845
Y2H Array
32296183
Intra MOS P00540 KIFAP3 Homo sapiens Q92845
Y2H Prey Pooling
32296183
Intra MOS P00540 DZIP1 Homo sapiens Q86YF9
Y2H Prey Pooling
32296183
Intra MOS P00540 DZIP1 Homo sapiens Q86YF9
Validated Y2H
32296183
Intra MOS P00540 DZIP1 Homo sapiens Q86YF9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08598 MOS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MOS VGNC VGNC:68300
Bos taurus MOS VGNC VGNC:31563
Rattus norvegicus MOS RGD RGD:3103
Macaca mulatta MOS VGNC VGNC:74911
Mus musculus MOS MGD MGI:97052
Canis familiaris MOS VGNC VGNC:43323
Macaca fascicularis MOS NCBI NCBI:102119783
Others MOS NCBI