SNRNP70 - small nuclear ribonucleoprotein U1 subunit 70 Gene

Homo sapiens

Also known as RPU1; Snp1; U1AP; U170K; U1RNP; RNPU1Z; SNRP70; U1-70K

Gene ID: 6625 | Gene type: protein coding

About SNRNP70

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,085,451-49,108,604 (from NCBI)

This gene has 10 transcripts (splice variants), 162 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 63.5), spleen (RPKM 63.2) and 25 other tissues.

Summary

Enables U1 snRNA binding activity. Involved in mRNA splicing, via spliceosome and regulation of RNA splicing. Located in nucleoplasm. Part of U1 snRNP and spliceosomal complex. Implicated in disease of mental health and systemic lupus erythematosus. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

SNRNP70 Products(2)

mRNA	Protein	Name
NM_001301069.2	NP_001287998.1	U1 small nuclear ribonucleoprotein 70 kDa isoform 2
NM_003089.6	NP_003080.2	U1 small nuclear ribonucleoprotein 70 kDa isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IMP IMP: Inferred from mutant phenotype	2467746	GOA
enables U1 snRNA binding	IDA IDA: Inferred from direct assay	21113136	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9447963	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	9531537	GOA
involved in regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	2467746	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U1 snRNP	IDA IDA: Inferred from direct assay	21113136	GOA
part of U1 snRNP	IPI IPI: Inferred from physical interaction	33677607	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18559850	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	9531537	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	33677607	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRNP70 Protein Structure

U1snRNP70_N

RRM_1

0
100
200
300
400
437 a.a.

Protein Preferred Names

Protein Names

U1 small nuclear ribonucleoprotein 70 kDa

U1 snRNP 70 kDa

SNRNP70 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNRNP70	P08621	TIA1	Homo sapiens	P31483	Anti Bait CoIP	12486009
Intra	SNRNP70	P08621	SMN1	Homo sapiens	Q16637	Anti Tag CoIP	33961781
Intra	SNRNP70	P08621	SMN1	Homo sapiens	Q16637	Pull Down	26828962
Intra	SNRNP70	P08621	SRSF1	Homo sapiens	Q07955	FRET	18559666
Intra	SNRNP70	P08621	SRSF1	Homo sapiens	Q07955	Anti Tag CoIP	33961781
Intra	SNRNP70	P08621	SRSF1	Homo sapiens	Q07955	Anti Bait CoIP	18559666
Intra	SNRNP70	P08621	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	SNRNP70	P08621	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	SNRNP70	P08621	GTPBP2	Homo sapiens	Q9BX10	Validated Y2H	32296183
Intra	SNRNP70	P08621	CEP63	Homo sapiens	Q96MT8	Y2H	17043677
Intra	SNRNP70	P08621	CLK2	Homo sapiens	P49760	Y2H Array	21988832
Intra	SNRNP70	P08621	CLK2	Homo sapiens	P49760	Anti Tag CoIP	33961781
Intra	SNRNP70	P08621	CLK2	Homo sapiens	P49760	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mixed Connective Tissue Disease

Sharp Syndrome	Mctd
Connective Tissue Disease Overlap Syndrome	Mixed Collagen Vascular Disease
Mctd - [Mixed Connective Tissue Disease]

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Disease Of Mental Health

Mental Health

Mental Disorders

Systemic Scleroderma

Scleroderma	Progressive Systemic Sclerosis
Systemic Sclerosis	Scleroderma, Systemic
Scleroderma Syndrome	Dermatosclerosis
Familial Progressive Scleroderma	Progressive Scleroderma
Scleroderma Disease	Scleroderma, Localized
Diffuse Scleroderma	Scleroderma, Familial Progressive

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diffuse Scleroderma

Diffuse Systemic Sclerosis	Systemic Sclerosis, Diffuse
Scleroderma, Diffuse	Systemic Scleroderma
Progressive System Sclerosis

Facial Hemiatrophy

Parry-Romberg Syndrome

Dyskinesia Of Esophagus

Esophageal Motility Disorders	Dyskinesia Of Oesophagus
Esophageal Dysmotility	Esophageal Motility Disorder
Oesophageal Dysmotility	Oesophageal Motor Disorder
Esophageal Spasm

Heart Block, Congenital

Congenital Heart Block	Heart Block Congenital
Congenital Atrioventricular Block

Collagen Disease

Collagen Diseases

Collagen Disorder

Epidermolysis Bullosa Dystrophica, Pretibial

Epidermolysis Bullosa, Pretibial	Pretibial Dystrophic Epidermolysis Bullosa
Deb-Pt	Dystrophic Epidermolysis Bullosa, Pretibial
Deb, Pretibial	Pretibial Epidermolysis Bullosa
Pretibial Deb	Localized Dystrophic Epidermolysis Bullosa, Pretibial Form
Localized Deb, Pretibial Form	Epidermolysis Bullosa Dystrophica, Pretibial Type
PR-DEB

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Crest Syndrome

Libman-Sacks Endocarditis

Libmann-Sachs, Endocarditis In Systemic Lupus Erythematosus

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Localized Scleroderma

Morphea	Localised Scleroderma
Localized Fibrosing Scleroderma	Circumscribed Scleroderma
Localised Morphea	Localised Morphoea
Localized Morphea	Scleroderma, Circumscribed Or Localised
Scleroderma, Circumscribed Or Localized	Scleroderma, Localized

Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome

Childhood Type Dermatomyositis

Juvenile Dermatomyositis	Juvenile Dm
Childhood Dermatomyositis	Amyopathic Dermatomyositis
Adm	Dermatomyositis Sine Myositis
Dermatomyositis, Childhood Type

Cerebritis

Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia	Lip Disease
Lip Diseases	LIP
Disease Of Lips

Autoimmune Disease Of Exocrine System

Raynaud Disease

Raynaud'S Disease	Raynaud Phenomenon
Raynaud'S Syndrome	Raynaud'S
Cold Fingers, Hereditary	Raynaud'S Phenomenon
Raynaud'S Disease/Phenomenon	Raynauds Syndrome
Raynauds Phenomenon	Secondary Raynaud'S Phenomenon
Raynaud Syndrome

Telangiectasis

Telangiectasia

Splenic Tuberculosis

Tuberculosis, Splenic

Hypotrichosis 13

HYPT13	Hypotrichosis With Woolly Hair
Hypotrichosis, Type 13

Aggressive Systemic Mastocytosis

Asm	Lymphadenopathic Mastocytosis With Eosinophilia

Myopathy

Muscular Diseases

Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13499	SNRNP70 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNRNP70	MGD	MGI:98341
Canis familiaris	SNRNP70	VGNC	VGNC:46609
Rattus norvegicus	SNRNP70	RGD	RGD:1307120
Macaca mulatta	SNRNP70	VGNC	VGNC:77673
Bos taurus	SNRNP70	VGNC	VGNC:35073

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