SNRPA1 - small nuclear ribonucleoprotein polypeptide A' Gene

Homo sapiens

Also known as Lea1; U2A'

Gene ID: 6627 | Gene type: protein coding

About SNRPA1

Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:101,281,510-101,295,248 (from NCBI)

This gene has 15 transcripts (splice variants), 231 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 26.0), testis (RPKM 22.8) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and spermatogenesis. Located in nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Implicated in connective tissue disease. [provided by Alliance of Genome Resources, Apr 2022]

SNRPA1 Products(1)

mRNA	Protein	Name
NM_003090.4	NP_003081.2	U2 small nuclear ribonucleoprotein A'

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9716128	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
involved in spermatogenesis	IGI IGI: Inferred from genetic interaction	27035939	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28076346	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	9731529	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPA1 Protein Structure

LRR_9

0
100
200
255 a.a.

Protein Preferred Names

Protein Names

U2 small nuclear ribonucleoprotein A'

U2 small nuclear ribonucleoprotein polypeptide A'

SNRPA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNRPA1	P09661	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Prey Pooling	32296183
Intra	SNRPA1	P09661	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	32296183
Intra	SNRPA1	P09661	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Array	32296183
Intra	SNRPA1	P09661	SNRPB2	Homo sapiens	P08579	Anti Tag CoIP	33961781
Intra	SNRPA1	P09661	SNRPB2	Homo sapiens	P08579	Anti Tag CoIP	28514442
Intra	SNRPA1	P09661	SNRPB2	Homo sapiens	P08579	Anti Tag CoIP	22365833
Intra	SNRPA1	P09661	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	SNRPA1	P09661	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	SNRPA1	P09661	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	SNRPA1	P09661	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	SNRPA1	P09661	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	28514442
Intra	SNRPA1	P09661	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	SNRPA1	P09661	ISY1	Homo sapiens	Q9ULR0	Anti Tag CoIP	33961781
Intra	SNRPA1	P09661	XAB2	Homo sapiens	Q9HCS7	Crosslink	25599396
Intra	SNRPA1	P09661	XAB2	Homo sapiens	Q9HCS7	Anti Tag CoIP	33961781
Intra	SNRPA1	P09661	XAB2	Homo sapiens	Q9HCS7	Anti Tag CoIP	28514442
Intra	SNRPA1	P09661	SNRPF	Homo sapiens	P62306	Anti Tag CoIP	33961781
Intra	SNRPA1	P09661	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	25416956
Intra	SNRPA1	P09661	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	32296183
Intra	SNRPA1	P09661	SNRPA	Homo sapiens	P09012	Y2H Array	25416956
Intra	SNRPA1	P09661	SNRPA	Homo sapiens	P09012	Y2H Array	32296183
Intra	SNRPA1	P09661	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	SNRPA1	P09661	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	SNRPA1	P09661	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Primary Optic Atrophy

Galloway-Mowat Syndrome 1

Galloway Syndrome	Nephrosis-Neuronal Dysmigration Syndrome
Nephrosis-Microcephaly Syndrome	Camos
Scar5	GAMOS1
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Microcephaly, Hiatal Hernia And Nephrotic Syndrome
Cerebellar Ataxia With Mental Retardation, Optic Atrophy, And Skin Abnormalities	Spinocerebellar Ataxia, Autosomal Recessive 5, Formerly
Scar5, Formerly	Spinocerebellar Ataxia Autosomal Recessive 5
Cerebellar Ataxia With Intellectual Disability Optic Atrophy And Skin Abnormalities	Camos Syndrome
Cerebellar Ataxia-Intellectual Disability-Optic Atrophy-Skin Abnormalities Syndrome	Galloway-Mowat Syndrome
Spinocerebellar Ataxia, Autosomal Recessive, 5	Galloway Mowat Syndrome
Spinocerebellar Ataxia, Autosomal Recessive 5

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13501	SNRPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNRPA1	RGD	RGD:2320494
Felis catus	SNRPA1	VGNC	VGNC:80840
Canis familiaris	SNRPA1	VGNC	VGNC:46610
Mus musculus	SNRPA1	MGD	MGI:1916231
Macaca mulatta	SNRPA1	VGNC	VGNC:77675
Bos taurus	SNRPA1	VGNC	VGNC:35075

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