2. Gene
  3. SNRPB2 - small nuclear ribonucleoprotein polypeptide B2 Gene

SNRPB2 - small nuclear ribonucleoprotein polypeptide B2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Msl1; U2B''

Gene ID: 6629 | Gene type: protein coding

About SNRPB2

Cytogenetic location: 20p12.1 Genomic coordinates (GRCh38): 20:16,730,026-16,742,564 (from NCBI)

This gene has 3 transcripts (splice variants), 248 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 22.1), appendix (RPKM 20.1) and 25 other tissues.

Summary

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SNRPB2 Products(2)

mRNA Protein Name
NM_003092.5 NP_003083.1 U2 small nuclear ribonucleoprotein B''
NM_198220.3 NP_937863.1 U2 small nuclear ribonucleoprotein B''
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9716128 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
Cellular Component GO Annotation Evidence Reference Source
part of U2 snRNP IDA
IDA: Inferred from direct assay
2951739 GOA
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U2-type spliceosomal complex IDA
IDA: Inferred from direct assay
32494006 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28076346 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
9731529 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPB2 Protein Structure

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (27 - 84)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (153 - 212)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

U2 small nuclear ribonucleoprotein B''

U2 snRNP B''

SNRPB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SNRPB2 P08579 HOMEZ Homo sapiens Q8IX15-3
Y2H Array
25416956
Intra
SNRPB2 P08579 HOMEZ Homo sapiens Q8IX15-3
Validated Y2H
25416956
Intra
SNRPB2 P08579 ZBTB14 Homo sapiens O43829
Y2H Array
25416956
Intra
SNRPB2 P08579 ZBTB14 Homo sapiens O43829
Y2H Array
32296183
Intra
SNRPB2 P08579 ZBTB14 Homo sapiens O43829
Y2H Prey Pooling
32296183
Intra
SNRPB2 P08579 CMTM6 Homo sapiens Q9NX76
Validated Y2H
32296183
Intra
SNRPB2 P08579 CMTM6 Homo sapiens Q9NX76
Y2H Array
32296183
Intra
SNRPB2 P08579 CMTM6 Homo sapiens Q9NX76
Y2H Prey Pooling
32296183
Intra
SNRPB2 P08579 SF3A2 Homo sapiens Q15428
Anti Tag CoIP
33961781
Intra
SNRPB2 P08579 SF3A2 Homo sapiens Q15428
Anti Tag CoIP
35271311
Intra
SNRPB2 P08579 SF3A2 Homo sapiens Q15428
Affinity Chrom
17332742
Intra
SNRPB2 P08579 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
25416956
Intra
SNRPB2 P08579 PNMA1 Homo sapiens Q8ND90
Validated Y2H
25416956
Intra
SNRPB2 P08579 PNMA1 Homo sapiens Q8ND90
BFG-2H
27107012
Intra
SNRPB2 P08579 PNMA1 Homo sapiens Q8ND90
Validated Y2H
27107012
Intra
SNRPB2 P08579 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
25416956
Intra
SNRPB2 P08579 SNRPD3 Homo sapiens P62318
Anti Tag CoIP
33961781
Intra
SNRPB2 P08579 MCM6 Homo sapiens Q14566
Y2H Array
25416956
Intra
SNRPB2 P08579 ALAS1 Homo sapiens P13196
Y2H Array
32296183
Intra
SNRPB2 P08579 ALAS1 Homo sapiens P13196
Validated Y2H
32296183
Intra
SNRPB2 P08579 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
32296183
Intra
SNRPB2 P08579 GABPB1 Homo sapiens Q06547
Y2H Prey Pooling
25416956
Intra
SNRPB2 P08579 GABPB1 Homo sapiens Q06547
Y2H Array
25416956
Intra
SNRPB2 P08579 NAP1L5 Homo sapiens Q96NT1
Validated Y2H
32296183
Intra
SNRPB2 P08579 NAP1L5 Homo sapiens Q96NT1
Y2H Array
32296183
Intra
SNRPB2 P08579 NAP1L5 Homo sapiens Q96NT1
Y2H Prey Pooling
32296183
Intra
SNRPB2 P08579 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
SNRPB2 P08579 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
SNRPB2 P08579 TRIM27 Homo sapiens P14373
Validated Y2H
32296183
Intra
SNRPB2 P08579 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra
SNRPB2 P08579 TRIM23 Homo sapiens P36406
Validated Y2H
32296183
Intra
SNRPB2 P08579 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra
SNRPB2 P08579 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
SNRPB2 P08579 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
SNRPB2 P08579 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
SNRPB2 P08579 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
SNRPB2 P08579 GABPB2 Homo sapiens Q8TAK5
Y2H Array
32296183
Intra
SNRPB2 P08579 GABPB2 Homo sapiens Q8TAK5
Y2H Prey Pooling
32296183
Intra
SNRPB2 P08579 GABPB2 Homo sapiens Q8TAK5
Validated Y2H
32296183
Intra
SNRPB2 P08579 SNRPA1 Homo sapiens P09661
Y2H
22365833
Intra
SNRPB2 P08579 SNRPA1 Homo sapiens P09661
Y2H Array
31515488
Intra
SNRPB2 P08579 SNRPA1 Homo sapiens P09661
Anti Tag CoIP
33961781
Intra
SNRPB2 P08579 SNRPA1 Homo sapiens P09661
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13503 SNRPB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SNRPB2 RGD RGD:1310194
Felis catus SNRPB2 VGNC VGNC:65536
Mus musculus SNRPB2 MGD MGI:104805
Macaca mulatta SNRPB2 VGNC VGNC:108058
Bos taurus SNRPB2 VGNC VGNC:35077