SRM - spermidine synthase Gene

Homo sapiens

Also known as PAPT; SPS1; SPDSY; SRML1

Gene ID: 6723 | Gene type: protein coding

About SRM

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,054,589-11,060,018 (from NCBI)

This gene has 6 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 19.8), lymph node (RPKM 14.2) and 25 other tissues.

Summary

The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four Enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This Enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]

SRM Products(1)

mRNA	Protein	Name
NM_003132.3	NP_003123.2	spermidine synthase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17585781	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17585781	GOA
enables spermidine synthase activity	IDA IDA: Inferred from direct assay	17585781	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in spermidine biosynthetic process	IDA IDA: Inferred from direct assay	17585781	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRM Protein Structure

Spermine_synth

0
100
200
302 a.a.

Protein Preferred Names

Protein Names

spermidine synthase

putrescine aminopropyltransferase

SRM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SRM	P19623	SRM	Homo sapiens	P19623	X-Ray Diffraction	17585781
Intra	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Prey Pooling	32296183
Intra	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Array	32296183
Intra	SRM	P19623	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Array	29892012
Intra	SRM	P19623	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	31515488
Intra	SRM	P19623	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Array	31515488
Intra	SRM	P19623	SRM	Homo sapiens	P19623	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Chagas Disease

American Trypanosomiasis	Chagas' Disease
Chagas' Disease With Digestive System Involvement	Chagas' Disease With Nervous System Involvement
Chagas' Disease With Other Organ Involvement	Infection Due To Trypanosoma Cruzi
South American Trypanosomiasis	Chronic Chagas Disease With Digestive System Involvement

Leishmaniasis

Post-Kala-Azar Dermal Leishmaniasis	Post Kala-Azar Dermal Leishmaniasis
Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis	Cutaneous Leishmaniasis
Kala-Azar	Visceral Leishmaniasis
Leishmaniasis, Cutaneous	Leishmaniasis, Visceral
Leishmania	Leishmania Infection
Leishmaniosis

Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome	Mental Retardation, X-Linked, Snyder-Robinson Type
Spermine Synthase Deficiency	Srs
Snyder-Robinson Mental Retardation Syndrome	X-Linked Intellectual Disability Snyder-Robinson Type
Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type	Snyder-Robinson X-Linked Mental Retardation Syndrome

Secondary Progressive Multiple Sclerosis

Secondary-Progressive Ms	Spms
Multiple Sclerosis, Chronic Progressive	Chronic Progressive Multiple Sclerosis
Multiple Sclerosis, Secondary Progressive

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120111	MW-150	Inhibitor	99.89%	Unkown
HY-131028	Janelia Fluor® 646 TFA		≥95.0%	Unkown
HY-131029	Janelia Fluor® 646, Maleimide		≥95.0%	Unkown
HY-P3146S	FTISADTSK-13C6,15N2 TFA		99.02%	Unkown
HY-P3146A	FTISADTSK acetate		99.66%	Unkown
HY-131026	Janelia Fluor® 635, SE		99.30%	Unkown
HY-120111A	MW-150 hydrochloride	Inhibitor	/	Unkown
HY-120111B	MW-150 dihydrochloride dihydrate	Inhibitor	/	Unkown
HY-120796	MW108 hydrochloride	Inhibitor	/	Unkown
HY-P3146	FTISADTSK		/	Unkown
HY-RS13769	SRM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13770	SRMS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-152901	Chol-N3		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SRM	VGNC	VGNC:35282
Rattus norvegicus	SRM	RGD	RGD:620796
Mus musculus	SRM	MGD	MGI:102690
Canis familiaris	SRM	VGNC	VGNC:46805
Felis catus	SRM	VGNC	VGNC:82543
Others	SRM	NCBI

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