TYK2 - tyrosine kinase 2 Gene

Homo sapiens

Also known as JTK1; IMD35

Gene ID: 7297 | Gene type: protein coding

About TYK2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,350,533-10,380,572 (from NCBI)

This gene has 35 transcripts (splice variants), 197 orthologues, 32 paralogues and is associated with 4 phenotypes. Ubiquitous expression in spleen (RPKM 21.6), bone marrow (RPKM 20.9) and 25 other tissues.

Summary

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II Cytokine Receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]

TYK2 Products(21)

mRNA	Protein	Name
NM_001385200.1	NP_001372129.1	non-receptor tyrosine-protein kinase TYK2 isoform 6
NM_001385197.1	NP_001372126.1	non-receptor tyrosine-protein kinase TYK2 isoform 3
NM_001385204.1	NP_001372133.1	non-receptor tyrosine-protein kinase TYK2 isoform 1
NM_001385199.1	NP_001372128.1	non-receptor tyrosine-protein kinase TYK2 isoform 5
NM_001406461.1	NP_001393390.1	non-receptor tyrosine-protein kinase TYK2 isoform 2
XM_047439305.1	XP_047295261.1	non-receptor tyrosine-protein kinase TYK2 isoform X4
NM_001385202.1	NP_001372131.1	non-receptor tyrosine-protein kinase TYK2 isoform 8
NM_001385206.1	NP_001372135.1	non-receptor tyrosine-protein kinase TYK2 isoform 11
XM_011528249.3	XP_011526551.1	non-receptor tyrosine-protein kinase TYK2 isoform X5
NM_001385201.1	NP_001372130.1	non-receptor tyrosine-protein kinase TYK2 isoform 7
XM_011528245.2	XP_011526547.1	non-receptor tyrosine-protein kinase TYK2 isoform X1
NM_003331.5	NP_003322.3	non-receptor tyrosine-protein kinase TYK2 isoform 2
XM_047439304.1	XP_047295260.1	non-receptor tyrosine-protein kinase TYK2 isoform X2
NM_001385207.1	NP_001372136.1	non-receptor tyrosine-protein kinase TYK2 isoform 12
XM_047439307.1	XP_047295263.1	non-receptor tyrosine-protein kinase TYK2 isoform X7
XM_011528246.4	XP_011526548.1	non-receptor tyrosine-protein kinase TYK2 isoform X3
XM_011528247.2	XP_011526549.1	non-receptor tyrosine-protein kinase TYK2 isoform X3
NM_001385205.1	NP_001372134.1	non-receptor tyrosine-protein kinase TYK2 isoform 10
XM_047439306.1	XP_047295262.1	non-receptor tyrosine-protein kinase TYK2 isoform X6
NM_001385203.1	NP_001372132.1	non-receptor tyrosine-protein kinase TYK2 isoform 9
NM_001385198.1	NP_001372127.1	non-receptor tyrosine-protein kinase TYK2 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables growth hormone receptor binding	IPI IPI: Inferred from physical interaction	10502458	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7526154	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	1386289	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	10542297	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	7526154	GOA
involved in interleukin-10-mediated signaling pathway	IDA IDA: Inferred from direct assay	7543512	GOA
involved in interleukin-12-mediated signaling pathway	IDA IDA: Inferred from direct assay	7528775	GOA
involved in interleukin-23-mediated signaling pathway	IDA IDA: Inferred from direct assay	7528775	GOA
involved in positive regulation of NK T cell proliferation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	11114383	GOA
involved in positive regulation of natural killer cell proliferation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	8605876	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	7638186	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	12023369	GOA
involved in type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	8232552	GOA
involved in type II interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	8232552	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10502458	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10502458	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TYK2 Protein Structure

Pkinase_Tyr

0
200
400
600
800
1000
1187 a.a.

Protein Preferred Names

Protein Names

non-receptor tyrosine-protein kinase TYK2

Related Diseases

Diseases

Alias

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Pneumonia

Acute Pneumonia	Pneumonias
Infectious Pneumonia	Pn - [Pneumonia]
Lobar Pneumonia Nos	Multifocal Pneumonia
Orthostatic Pneumonia	Pneumonia Nos
Chronic Pneumonia Nos	Atypical Pneumonia
Passive Pneumonia	Purulent Pneumonia
Interstitial Lobar Pneumonia	Pneumonia, Unspecified
Pneumonia Due To Chlamydia	Pneumonia Due To Chlamydia Pneumoniae
Pneumonia Due To E. Coli	Escherichia Coli Lobar Pneumonia
Pneumonia Due To H. Influenzae	Pneumonia Due To Hemophilus Influenzae
Bronchopneumonia Due To H. Influenzae	Haemophilus Influenzae Lobar Pneumonia
Bronchopneumonia Due To Hemophilus Influenzae	Pseudomonal Pneumonia
Pseudomonas Pneumonia	Pseudomonas Lobar Pneumonia
Staphylococcal Pneumonia	Staphylococcus Pneumonia
Acute Staphylococcal Pneumonia	Staphylococcal Double Pneumonia
Staphylococcal Lobar Pneumonia	Staphylococcal Purulent Pneumonia
Staphylococcal Bronchopneumonia	Pneumococcal Pneumonia
Pneumococcus Pneumonia	Bronchopneumonia Due To S. Pneumoniae
Pneumococcal Lobar Pneumonia	Streptococcal Pneumoniae Pneumonia
Streptococcus Pneumoniae Lobar Pneumonia	Pyemic Pneumococcal Embolism With Pneumonia
Bronchopneumonia Due To Streptococcus Pneumoniae	Pneumonia Due To Streptococcus, Group B
Group B Streptococcal Pneumonia	Adenovirus Pneumonia
Adenoviral Pneumonia	Adenovirus Viral Pneumonia
Pneumonia Respiratory Syncytial Viral	Parainfluenza Viral Pneumonia
Parainfluenzal Pneumonia	Parainfluenza Virus Pneumonia
Human Metapneumovirus Pneumonia	Human Metapneumovirus Infection Resulting In Pneumonia
Pneumocystis Pneumonia	Plasma Cells Pneumonia

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Alopecia Universalis Congenita

Alopecia Universalis	ALUNC
Atrichia, Generalized	Au
Alopecia Areata Universalis	Atrichia Generalized

Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome	Hyper-Ige Recurrent Infection Syndrome 1
Hyperimmunoglobulin E Syndrome	Job'S Syndrome
Recurring Cold Staphylococcal Abscesses	Ige Syndromes
Buckley Syndrome	Hie - [Hyperimmunoglobulin E] Syndrome
Job-Buckley Syndrome	Quie-Hill Syndrome

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Polycythemia Vera

PV	Polycythemia Rubra Vera
Prv	Osler-Vaquez Disease
Chronic Erythremia	Polycythaemia Rubra Vera
Primary Polycythemia	Vaquez Disease
Polycythemia Vera, Somatic	Osler-Vaquez Syndrome
Proliferative Polycythaemia	Polycythemia Ruba Vera
Acquired Primary Erythrocytosis	Heilmeyer-Schoner Disease
Vaquez Osler Disease	Primary Polycythaemia

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Encephalopathy With Basal Ganglia Calcification	Aicardi-Goutières Syndrome
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Myeloproliferative Neoplasm

Myeloproliferative Disorder	Chronic Myeloproliferative Disease
Myeloproliferative Neoplasms	Chronic Myeloproliferative Disorder
Cmpd	Cmpd, U
Chronic Myeloproliferative Disorders	Mpd
Mpn	Myeloproliferative Disorders
Myeloproliferative Disease	Campomelic Dysplasia

Immunodeficiency 35

Tyrosine Kinase 2 Deficiency	IMD35
Tyk2 Deficiency	Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis
Susceptibility To Infection Due To Tyk2 Deficiency	Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive
Hies With Atypical Mycobacteriosis, Autosomal Recessive	Autosomal Recessiv Hies With Atypical Mycobacteriosis
Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency	Autosomal Recessive Hies With Atypical Mycobacteriosis

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Autoimmune Disease Of Skin And Connective Tissue

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behet'S Syndrome
Bd Syndrome	Behçet Syndrome
Behçet'S Disease	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

B Cell Deficiency

Immunoglobulin Heavy Chain Deficiency	B Cell Deficiencies
Immunoglobulin Heavy Chain Deletion	Humoral Immune Defect

Primary Cutaneous Anaplastic Large Cell Lymphoma

Primary C-Alcl	Regressive Atypical Histiocytosis
Lymphoma, Primary Cutaneous Anaplastic Large Cell

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Crisponi/Cold-Induced Sweating Syndrome 2

Cold-Induced Sweating Syndrome 2	CISS2
Sweating Syndrome, Cold-Induced, Type 2

Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis	Duncan Disease
Purtilo Syndrome	X-Linked Lymphoproliferative Syndrome
Xlp	XLP1
Lyp	X-Linked Lymphoproliferative Disease
Lymphoproliferative Disease, X-Linked	Xlpd
X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency	Ebv Infection, Severe, Susceptibility To
Ebvs	Immunodeficiency 5
Imd5	X-Linked Lymphoproliferative Syndrome 1
Epstein-Barr Virus Infection, Familial Fatal	Ebv Infection, Severe
Infectious Mononucleosis, Severe	Infectious Mononucleosis, Severe, Susceptibility To
Immunodeficiency, X-Linked Progressive Combined Variable	Epstein Barr Virus Infection, Familial Fatal
X-Linked Progressive Combined Variable Immunodeficiency 5	Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males
Familial Fatal Epstein-Barr Infection	Severe Susceptibility To Ebv Infection
Severe Susceptibility To Infectious Mononucleosis	Sap Deficiency
Sh2d1a/Slam-Associated Protein Deficiency	X-Linked Lymphoproliferative Syndrome Type 1
X-Linked Progressive Combined Variable Immunodeficiency	Lymphoproliferative Syndrome, X-Linked
Sap	X-Linked Lymphoproliferative Disorder

Myeloma, Multiple

Multiple Myeloma	Kahler Disease
Myelomatosis	Plasma Cell Myeloma
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Multiple Myeloma, Susceptibility To	Myeloma - Multiple
Kahler'S Disease	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Lymphopenia

Lymphocytopenia

Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Skin Disease

Skin Diseases	Abnormality Of The Skin
Skin Diseases, Genetic	Genodermatosis
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Mixed Lacrimal Gland Cancer

Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland	Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland
Malignant Mixed Neoplasm Of Lacrimal Gland

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50856	Ruxolitinib	Inhibitor	99.99%	Yes
HY-19569	Upadacitinib	Inhibitor	99.98%	Yes
HY-117287	Deucravacitinib	Inhibitor	99.87%	Unkown
HY-15315	Baricitinib	Inhibitor	99.97%	Yes
HY-50858	Ruxolitinib phosphate	Inhibitor	99.97%	Yes
HY-16379	Pacritinib	Inhibitor	99.93%	Yes
HY-18300	Filgotinib	Inhibitor	99.68%	Yes
HY-107429	Abrocitinib	Inhibitor	99.26%	Unkown
HY-19568	Peficitinib	Inhibitor	99.43%	Yes
HY-15315A	Baricitinib phosphate	Inhibitor	99.97%	Yes
HY-109053	Delgocitinib	Inhibitor	99.87%	Unkown
HY-13577A	Oclacitinib monomaleate	Inhibitor	99.63%	Unkown
HY-13577	Oclacitinib	Inhibitor	99.59%	Unkown
HY-18300A	Filgotinib maleate	Inhibitor	99.88%	Yes
HY-19569A	Upadacitinib tartrate tetrahydrate	Inhibitor	/	Unkown
HY-19568A	Peficitinib hydrobromide	Inhibitor	/	Unkown
HY-16379A	Pacritinib hydrochloride	Inhibitor	/	Unkown
HY-19568B	Peficitinib hydrochloride	Inhibitor	/	Unkown
HY-50859	Ruxolitinib sulfate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12469	Decernotinib	Inhibitor	99.91%	Phase 3
HY-15999	Cerdulatinib	Inhibitor	98.96%	Phase 3
HY-112724	Ivarmacitinib	Inhibitor	99.82%	Phase 3
HY-15999A	Cerdulatinib hydrochloride	Inhibitor	99.89%	Phase 3
HY-13034	Gandotinib	Inhibitor	99.82%	Phase 2
HY-15270	BMS-911543	Inhibitor	98.53%	Phase 2
HY-19631A	Ilginatinib	Inhibitor	99.94%	Phase 2
HY-19631B	Ilginatinib hydrochloride	Inhibitor	98.92%	Phase 2
HY-19631	Ilginatinib maleate	Inhibitor	99.87%	Phase 2
HY-131968	BMS-986202	Inhibitor	99.92%	Phase 1
HY-101024	PF-06263276	Inhibitor	99.38%	Phase 1

Pre-clinical Phase

Bioactive Molecules (34)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14435	Pyridone 6	Inhibitor	98.13%	Unkown
HY-14722	NVP-BSK805	Inhibitor	99.89%	Unkown
HY-100895	SAR-20347	Inhibitor	97.12%	Unkown
HY-101762	TyK2-IN-2	Inhibitor	98.64%	Unkown
HY-111745	Tyk2-IN-5	Inhibitor	98.87%	Unkown
HY-14722A	NVP-BSK805 dihydrochloride	Inhibitor	99.36%	Unkown
HY-120469	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	Inhibitor	99.80%	Unkown
HY-126242S	Tyk2-IN-7	Inhibitor	99.62%	Unkown
HY-131906	JAK2-IN-7	Inhibitor	99.15%	Unkown
HY-111750	JAK-IN-3	Inhibitor	98.92%	Unkown
HY-16640	TCJL37	Inhibitor	99.89%	Unkown
HY-13961	GLPG0634 analog	Inhibitor	98.07%	Unkown
HY-152080	TUL01101	Inhibitor	99.71%	Unkown
HY-153440	JAK-IN-25	Inhibitor	98.44%	Unkown
HY-18710	BMS-066	Inhibitor	99.09%	Unkown
HY-150720	TYK2-IN-12	Inhibitor	98.43%	Unkown
HY-14722C	NVP-BSK805 trihydrochloride	Inhibitor	/	Unkown
HY-163304	Tyk2-IN-16	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown
HY-148060	JAK-IN-21	Inhibitor	99.72%	Unkown
HY-149296	JAK1-IN-12	Inhibitor	/	Unkown
HY-154994	JAK-IN-30	Inhibitor	/	Unkown
HY-158692	Tyk2-IN-18	Inhibitor	/	Unkown
HY-157121	JAK-IN-34	Inhibitor	/	Unkown
HY-147754	JAK3/BTK-IN-6	Inhibitor	/	Unkown
HY-18709	Tyk2-IN-3	Inhibitor	/	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-168269	Tyk2-IN-20	Inhibitor	/	Unkown
HY-143885	JAK1/TYK2-IN-3	Inhibitor	/	Unkown
HY-143884	JAK2/TYK2-IN-1	Inhibitor	/	Unkown
HY-163653	Zemprocitinib	Inhibitor	/	Unkown
HY-18315	Bayer-18	Inhibitor	/	Unkown
HY-123187	AS2553627	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TYK2	VGNC	VGNC:78680
Mus musculus	TYK2	MGD	MGI:1929470
Felis catus	TYK2	VGNC	VGNC:66736
Rattus norvegicus	TYK2	RGD	RGD:2320469
Canis familiaris	TYK2	VGNC	VGNC:48024
Bos taurus	TYK2	VGNC	VGNC:36548
Others	TYK2	NCBI