VAMP2 - vesicle associated membrane protein 2 Gene

Homo sapiens

Also known as SYB2; VAMP-2; NEDHAHM

Gene ID: 6844 | Gene type: protein coding

About VAMP2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,159,147-8,162,948 (from NCBI)

This gene has 4 transcripts (splice variants), 153 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 159.3), ovary (RPKM 45.0) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

VAMP2 Products(2)

mRNA	Protein	Name
NM_001330125.1	NP_001317054.1	vesicle-associated membrane protein 2 isoform 2
NM_014232.3	NP_055047.2	vesicle-associated membrane protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9920726	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	12855681	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in eosinophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
NOT involved in mucus secretion	IMP IMP: Inferred from mutant phenotype	22144578	GOA
NOT involved in natural killer cell degranulation	IMP IMP: Inferred from mutant phenotype	18042464	GOA
NOT involved in neutrophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
NOT involved in regulation of histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	18253931	GOA
involved in vesicle fusion	IMP IMP: Inferred from mutant phenotype	30929742	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	12130530	GOA
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	19478182	GOA
located in membrane	IDA IDA: Inferred from direct assay	16677249	GOA
NOT located in secretory granule membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in vesicle	IDA IDA: Inferred from direct assay	17313651	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAMP2 Protein Structure

Synaptobrevin

0
100
116 a.a.

Protein Preferred Names

Protein Names

vesicle-associated membrane protein 2

synaptobrevin 2

VAMP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VAMP2	P63027	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	VAMP2	P63027	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	VAMP2	P63027	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	VAMP2	P63027	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	VAMP2	P63027	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	VMA21	Homo sapiens	Q3ZAQ7	Validated Y2H	32296183
Intra	VAMP2	P63027	VMA21	Homo sapiens	Q3ZAQ7	Y2H Array	32296183
Intra	VAMP2	P63027	VMA21	Homo sapiens	Q3ZAQ7	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	VAMP2	P63027	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	VAMP2	P63027	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	VAMP2	P63027	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	VAMP2	P63027	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	PRKD3	Homo sapiens	O94806	Pull Down	17196367
Intra	VAMP2	P63027	PRKD3	Homo sapiens	O94806	Anti Tag CoIP	17196367
Intra	VAMP2	P63027	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	VAMP2	P63027	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	VAMP2	P63027	MARCHF8	Homo sapiens	Q5T0T0	Validated Y2H	32296183
Intra	VAMP2	P63027	MARCHF8	Homo sapiens	Q5T0T0	Y2H Array	32296183
Intra	VAMP2	P63027	MARCHF8	Homo sapiens	Q5T0T0	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	VAMP2	P63027	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	VAMP2	P63027	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	VAMP2	P63027	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	VAMP2	P63027	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	VAMP2	P63027	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	VAMP2	P63027	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	VAMP2	P63027	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	VAMP2	P63027	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	VAMP2	P63027	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	VAMP2	P63027	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	VAMP2	P63027	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	VAMP2	P63027	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	VAMP2	P63027	TMEM101	Homo sapiens	Q96IK0	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	TMEM101	Homo sapiens	Q96IK0	Validated Y2H	32296183
Intra	VAMP2	P63027	TMEM101	Homo sapiens	Q96IK0	Y2H Array	32296183
Intra	VAMP2	P63027	SNAP29	Homo sapiens	O95721	Y2H Prey Pooling	25416956
Intra	VAMP2	P63027	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	VAMP2	P63027	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	VAMP2	P63027	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	VAMP2	P63027	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	VAMP2	P63027	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	VAMP2	P63027	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	VAMP2	P63027	STX1A	Homo sapiens	Q16623	Anti Bait CoIP	20798282
Intra	VAMP2	P63027	STX4	Homo sapiens	Q12846	Validated Y2H	32296183
Intra	VAMP2	P63027	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	VAMP2	P63027	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	VAMP2	P63027	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	VAMP2	P63027	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	VAMP2	P63027	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	VAMP2	P63027	STX1B	Homo sapiens	P61266	Y2H Prey Pooling	32296183
Intra	VAMP2	P63027	STX1B	Homo sapiens	P61266	Y2H Array	32296183
Intra	VAMP2	P63027	SNCA	Homo sapiens	P37840	Anti Bait CoIP	20798282
Intra	VAMP2	P63027	SNCA	Homo sapiens	P37840	Pull Down	20798282
Intra	VAMP2	P63027	SNCA	Homo sapiens	P37840	Density Sedimentation	20798282
Cross	VAMP2	P63027	F	Clostridium botulinum	A7GBG3	Protease Assay	22172278

Cross: Cross-species interaction Intra: Intraspecies interaction

VAMP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81673	VAMP2 Antibody (YA1418)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Hypotonia And Autistic Features With Or Without Hyperkinetic Movements

NEDHAHM

Neurodevelopmental Disorder, Hypotonia And Autistic Features With/Without Hyperkinetic Movements

Tetanus

Lockjaw	Clostridial Tetanus
Infection Due To Clostridium Tetani	Lock-Jaw

Foodborne Botulism

Botulism	Botulism Poisoning
Intoxication With Clostridium Botulinum Toxin	Wound Botulism
Food Poisoning Due To Clostridium Botulinum	Infection Due To Clostridium Botulinum
Infant Botulism	Intoxication Botulism
Botulism, Infantile	Clostridium Botulinum Poisoning
Botulism Nos

Infant Botulism

Infant Intestinal Botulism	Infant Intestinal Toxemia Botulism
Infant Intestinal Toxin-Mediated Botulism	Infantile Botulism
Botulism, Infantile

Partial Optic Atrophy

Wound Botulism

Cutaneous Infectious Botulism	Cutaneous Toxin-Mediated Botulism
Inoculation Botulism	Skin Infectious Botulism
Skin Toxin-Mediated Botulism

Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia

Primary Bacterial Infectious Disease

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15594	VAMP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VAMP2	MGD	MGI:1313277
Rattus norvegicus	VAMP2	RGD	RGD:3949

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