2. Gene
  3. STX4 - syntaxin 4 Gene

STX4 - syntaxin 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as STX4A; p35-2

Gene ID: 6810 | Gene type: protein coding

About STX4

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,033,095-31,040,168 (from NCBI)

This gene has 17 transcripts (splice variants), 191 orthologues and 12 paralogues. Ubiquitous expression in spleen (RPKM 17.8), adrenal (RPKM 16.5) and 25 other tissues.

Summary

Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lamellipodium. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]

STX4 Products(3)

mRNA Protein Name
NM_001272095.1 NP_001259024.1 syntaxin-4 isoform 1
NM_001272096.1 NP_001259025.1 syntaxin-4 isoform 2
NM_004604.5 NP_004595.2 syntaxin-4 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12130530 GOA
enables sphingomyelin phosphodiesterase activator activity IMP
IMP: Inferred from mutant phenotype
20956541 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
22226963 GOA
involved in cornified envelope assembly IDA
IDA: Inferred from direct assay
22226963 GOA
involved in long-term synaptic potentiation IDA
IDA: Inferred from direct assay
20434989 GOA
involved in organelle fusion IDA
IDA: Inferred from direct assay
20434989 GOA
involved in positive regulation of catalytic activity IMP
IMP: Inferred from mutant phenotype
20956541 GOA
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
21720706 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
15351710 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21720706 GOA
involved in positive regulation of chemotaxis IMP
IMP: Inferred from mutant phenotype
21720706 GOA
involved in positive regulation of eosinophil degranulation IMP
IMP: Inferred from mutant phenotype
16677249 GOA
involved in positive regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
24055037 GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
24552216 GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
12855681 GOA
involved in positive regulation of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
21720706 GOA
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
15351710 GOA
involved in regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
20434989 GOA
involved in regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
20956541 GOA
involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
36355422 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SNARE complex IDA
IDA: Inferred from direct assay
12130530 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16339081 GOA
located in cell surface IDA
IDA: Inferred from direct assay
15576373 GOA
located in dendritic spine IDA
IDA: Inferred from direct assay
20434989 GOA
located in endosome IDA
IDA: Inferred from direct assay
20956541 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
22226963 GOA
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
27662481 GOA
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
27662481 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
21720706 GOA
located in membrane IDA
IDA: Inferred from direct assay
7690687 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20956541 GOA
is active in postsynapse IDA
IDA: Inferred from direct assay
27662481 GOA
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
27662481 GOA
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
20434989 GOA
located in specific granule IDA
IDA: Inferred from direct assay
18588921 GOA
located in synapse IDA
IDA: Inferred from direct assay
20434989 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX4 Protein Structure

Syntaxin

Syntaxin: Syntaxin (39 - 137)

SNARE

SNARE: SNARE domain (206 - 267)

  • 0
  • 100
  • 200
  • 297 a.a.
Protein Preferred Names Protein Names

syntaxin-4

renal carcinoma antigen NY-REN-31

STX4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra STX4 Q12846 VAMP5 Homo sapiens O95183
Y2H Array
32296183
Intra STX4 Q12846 VAMP5 Homo sapiens O95183
Y2H Prey Pooling
32296183
Intra STX4 Q12846 SNAP47 Homo sapiens Q5SQN1
Y2H Prey Pooling
25416956
Intra STX4 Q12846 SNAP47 Homo sapiens Q5SQN1
Y2H Array
25416956
Intra STX4 Q12846 SNAP47 Homo sapiens Q5SQN1
Validated Y2H
25416956
Intra STX4 Q12846 TMEM199 Homo sapiens Q8N511
Validated Y2H
32296183
Intra STX4 Q12846 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra STX4 Q12846 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra STX4 Q12846 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra STX4 Q12846 SEC22B Homo sapiens O75396
Anti Bait CoIP
22153078
Intra STX4 Q12846 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra STX4 Q12846 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra STX4 Q12846 ANKRD46 Homo sapiens Q86W74-2
Validated Y2H
32296183
Intra STX4 Q12846 FAXDC2 Homo sapiens Q96IV6
Validated Y2H
32296183
Intra STX4 Q12846 PLP1 Homo sapiens P60201-2
Y2H Array
32296183
Intra STX4 Q12846 PLP1 Homo sapiens P60201-2
Y2H Prey Pooling
32296183
Intra STX4 Q12846 TMEM203 Homo sapiens Q969S6
Validated Y2H
32296183
Intra STX4 Q12846 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra STX4 Q12846 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra STX4 Q12846 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra STX4 Q12846 STX3 Homo sapiens Q13277
Y2H Array
29892012
Intra STX4 Q12846 STX3 Homo sapiens Q13277
Y2H Array
31515488
Intra STX4 Q12846 STX3 Homo sapiens Q13277
Validated Y2H
32296183
Intra STX4 Q12846 STX3 Homo sapiens Q13277
Y2H Array
25416956
Intra STX4 Q12846 STX3 Homo sapiens Q13277
Y2H Prey Pooling
25416956
Intra STX4 Q12846 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra STX4 Q12846 RNF4 Homo sapiens P78317
Y2H Array
32296183
Cross STX4 Q12846 ap3a_sars2 SARS-CoV-2 P0DTC3
Confocal
34706264
Cross STX4 Q12846 ap3a_sars2 SARS-CoV-2 P0DTC3
Anti Tag CoIP
34706264
Intra STX4 Q12846 STX12 Homo sapiens Q86Y82
Y2H Array
31515488
Intra STX4 Q12846 STX12 Homo sapiens Q86Y82
Validated Y2H
25416956
Intra STX4 Q12846 STX12 Homo sapiens Q86Y82
Validated Y2H
32296183
Intra STX4 Q12846 STX12 Homo sapiens Q86Y82
Y2H Array
25416956
Intra STX4 Q12846 STX6 Homo sapiens O43752
Validated Y2H
25416956
Intra STX4 Q12846 STX6 Homo sapiens O43752
Y2H Array
25416956
Intra STX4 Q12846 STX6 Homo sapiens O43752
Y2H Prey Pooling
25416956
Intra STX4 Q12846 STX6 Homo sapiens O43752
Y2H
21516116
Intra STX4 Q12846 STX16 Homo sapiens O14662
Y2H Array
25416956
Intra STX4 Q12846 STX16 Homo sapiens O14662
Y2H Prey Pooling
25416956
Intra STX4 Q12846 STX16 Homo sapiens O14662
Validated Y2H
25416956
Intra STX4 Q12846 STX7 Homo sapiens O15400
Validated Y2H
25416956
Intra STX4 Q12846 STX7 Homo sapiens O15400
Y2H
21516116
Intra STX4 Q12846 PSMA3 Homo sapiens P25788
Y2H Array
25416956
Intra STX4 Q12846 PSMA3 Homo sapiens P25788
Validated Y2H
25416956
Intra STX4 Q12846 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra STX4 Q12846 GOSR2 Homo sapiens O14653
Validated Y2H
25416956
Intra STX4 Q12846 GOSR2 Homo sapiens O14653
Y2H Prey Pooling
25416956
Intra STX4 Q12846 VAMP2 Homo sapiens P63027
Y2H Prey Pooling
25416956
Intra STX4 Q12846 VAMP2 Homo sapiens P63027
Y2H Array
25416956
Intra STX4 Q12846 VAMP2 Homo sapiens P63027
Validated Y2H
25416956
Intra STX4 Q12846 GIMAP5 Homo sapiens Q96F15
Y2H Prey Pooling
25416956
Intra STX4 Q12846 GIMAP5 Homo sapiens Q96F15
Validated Y2H
25416956
Intra STX4 Q12846 GIMAP5 Homo sapiens Q96F15
Y2H Array
25416956
Intra STX4 Q12846 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra STX4 Q12846 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra STX4 Q12846 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra STX4 Q12846 STX5 Homo sapiens Q13190
Y2H Prey Pooling
25416956
Intra STX4 Q12846 STX5 Homo sapiens Q13190
Validated Y2H
25416956
Intra STX4 Q12846 STX5 Homo sapiens Q13190
Validated Y2H
32296183
Intra STX4 Q12846 STX5 Homo sapiens Q13190
Y2H Array
25416956
Intra STX4 Q12846 VAMP3 Homo sapiens Q15836
Anti Tag CoIP
25416956
Intra STX4 Q12846 VAMP3 Homo sapiens Q15836
Anti Bait CoIP
12130530
Intra STX4 Q12846 VAMP3 Homo sapiens Q15836
Y2H Pooling
16189514
Intra STX4 Q12846 VAMP3 Homo sapiens Q15836
Validated Y2H
32296183
Intra STX4 Q12846 VAMP3 Homo sapiens Q15836
Y2H Prey Pooling
25416956
Intra STX4 Q12846 VTI1B Homo sapiens Q9UEU0
Validated Y2H
25416956
Intra STX4 Q12846 VTI1B Homo sapiens Q9UEU0
Validated Y2H
32296183
Intra STX4 Q12846 VTI1B Homo sapiens Q9UEU0
Y2H Prey Pooling
25416956
Intra STX4 Q12846 STX8 Homo sapiens Q9UNK0
Validated Y2H
25416956
Intra STX4 Q12846 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra STX4 Q12846 STX8 Homo sapiens Q9UNK0
Y2H Array
25416956
Intra STX4 Q12846 USE1 Homo sapiens Q9NZ43
Validated Y2H
32296183
Intra STX4 Q12846 VAMP4 Homo sapiens O75379
Validated Y2H
25416956
Intra STX4 Q12846 VAMP4 Homo sapiens O75379
Y2H Prey Pooling
25416956
Intra STX4 Q12846 VAMP4 Homo sapiens O75379
Y2H Pooling
16189514
Intra STX4 Q12846 BET1 Homo sapiens O15155
Y2H Array
25416956
Intra STX4 Q12846 NAPA Homo sapiens P54920
Y2H Pooling
16189514
Intra STX4 Q12846 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Intra STX4 Q12846 CYBRD1 Homo sapiens Q53TN4
Validated Y2H
25416956
Intra STX4 Q12846 CYBRD1 Homo sapiens Q53TN4
Y2H Array
25416956
Intra STX4 Q12846 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
25416956
Intra STX4 Q12846 SEC22A Homo sapiens Q96IW7
Y2H Prey Pooling
25416956
Intra STX4 Q12846 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Type 1 Diabetes Mellitus 10

Diabetes Mellitus, Insulin-Dependent, 10

IDDM10

Insulin-Dependent Diabetes Mellitus 10

Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10

T1D10

Diabetes, Mellitus, Insulin-Dependent 10

Diabetes Mellitus, Insulin-Dependent, Type 10
Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4

FHL4

Hplh4

Hlh4

Lymphohistiocytosis, Hemophagocytic, Familial, Type 4
Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13984 STX4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta STX4 VGNC VGNC:99601
Felis catus STX4 VGNC VGNC:65814
Mus musculus STX4 MGD MGI:893577
Canis familiaris STX4 VGNC VGNC:46956
Rattus norvegicus STX4 RGD RGD:621019
Bos taurus STX4 VGNC VGNC:35440