PPP1R11 - protein phosphatase 1 regulatory inhibitor subunit 11 Gene

Homo sapiens

Also known as HCGV; IPP3; HCG-V; TCTE5; TCTEX5; CFAP255

Gene ID: 6992 | Gene type: protein coding

About PPP1R11

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,061,265-30,070,333 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 184 orthologues. Ubiquitous expression in small intestine (RPKM 46.4), thyroid (RPKM 45.6) and 25 other tissues.

Summary

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

PPP1R11 Products(1)

mRNA	Protein	Name
NM_021959.3	NP_068778.1	E3 ubiquitin-protein ligase PPP1R11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase binding	EXP EXP: Inferred from Experiment	9843442	GOA
enables phosphatase binding	IPI IPI: Inferred from physical interaction	9843442	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9843442	GOA
enables protein phosphatase inhibitor activity	IDA IDA: Inferred from direct assay	9843442	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	27805901	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	27805901	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R11 Protein Structure

PPI_Ypi1

0
100
126 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase PPP1R11

HCG V

PPP1R11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP1R11	O60927	YAF2	Homo sapiens	Q8IY57-5	Validated Y2H	32296183
Intra	PPP1R11	O60927	YAF2	Homo sapiens	Q8IY57-5	Y2H Prey Pooling	32296183
Intra	PPP1R11	O60927	YAF2	Homo sapiens	Q8IY57-5	Y2H Array	32296183
Intra	PPP1R11	O60927	CLSTN1	Homo sapiens	O94985-2	Validated Y2H	32814053
Intra	PPP1R11	O60927	CLSTN1	Homo sapiens	O94985-2	Y2H Array	32814053
Intra	PPP1R11	O60927	CLSTN1	Homo sapiens	O94985-2	Y2H Pooling	32814053
Intra	PPP1R11	O60927	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	PPP1R11	O60927	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	PPP1R11	O60927	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	PPP1R11	O60927	PPP1CB	Homo sapiens	P62140	Y2H Array	32296183
Intra	PPP1R11	O60927	PPP1CB	Homo sapiens	P62140	Y2H Prey Pooling	32296183
Intra	PPP1R11	O60927	PPP1CB	Homo sapiens	P62140	Validated Y2H	32296183
Intra	PPP1R11	O60927	PPP1CC	Homo sapiens	P36873	Y2H Prey Pooling	32296183
Intra	PPP1R11	O60927	PPP1CC	Homo sapiens	P36873	Validated Y2H	32296183
Intra	PPP1R11	O60927	PPP1CC	Homo sapiens	P36873	Y2H Array	32296183
Intra	PPP1R11	O60927	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	PPP1R11	O60927	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	PPP1R11	O60927	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	PPP1R11	O60927	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32296183
Intra	PPP1R11	O60927	IFT20	Homo sapiens	Q8IY31-3	Validated Y2H	32296183
Intra	PPP1R11	O60927	IFT20	Homo sapiens	Q8IY31-3	Y2H Prey Pooling	32296183
Cross	PPP1R11	O60927	PPP1CA	Oryctolagus cuniculus	P62139	Affinity Chrom	9843442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10977	PPP1R11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPP1R11	MGD	MGI:1923747
Canis familiaris	PPP1R11	VGNC	VGNC:44877
Bos taurus	PPP1R11	VGNC	VGNC:33222
Macaca mulatta	PPP1R11	VGNC	VGNC:82209
Rattus norvegicus	PPP1R11	RGD	RGD:1303163

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