TPD52L1 - TPD52 like 1 Gene

Homo sapiens

Also known as D53; TPD53

Gene ID: 7164 | Gene type: protein coding

About TPD52L1

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:125,153,773-125,264,407 (from NCBI)

This gene has 17 transcripts (splice variants), 202 orthologues and 3 paralogues. Broad expression in adrenal (RPKM 40.8), salivary gland (RPKM 18.6) and 14 other tissues.

Summary

This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced Apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]

TPD52L1 Products(8)

mRNA	Protein	Name
NM_001003395.3	NP_001003395.1	tumor protein D53 isoform 2
NM_001003396.3	NP_001003396.1	tumor protein D53 isoform 3
NM_001003397.3	NP_001003397.1	tumor protein D53 isoform 4
NM_001292026.3	NP_001278955.1	tumor protein D53 isoform 5
NM_001300994.3	NP_001287923.1	tumor protein D53 isoform 6
NM_001318903.2	NP_001305832.1	tumor protein D53 isoform 7
NM_001318907.2	NP_001305836.1	tumor protein D53 isoform 5
NM_003287.4	NP_003278.1	tumor protein D53 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	9484778	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9484778	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9484778	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	16112108	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	14761963	GOA
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	14761963	GOA
involved in positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	14761963	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12963375	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12963375	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPD52L1 Protein Structure

TPD52

0
100
204 a.a.

Protein Preferred Names

Protein Names

tumor protein D53

tumor protein D52 like 1

TPD52L1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TPD52L1	Q16890	TPD52	Homo sapiens	P55327	Anti Tag CoIP	33961781
Intra	TPD52L1	Q16890	YWHAB	Homo sapiens	P31946	Pull Down	12963375
Intra	TPD52L1	Q16890	YWHAB	Homo sapiens	P31946	Y2H	12963375
Intra	TPD52L1	Q16890	TPD52	Homo sapiens	P55327	Y2H	9484778
Intra	TPD52L1	Q16890	YWHAZ	Homo sapiens	P63104	CoIP	12963375
Intra	TPD52L1	Q16890	TPD52L3	Homo sapiens	Q96J77	Y2H	16631610
Intra	TPD52L1	Q16890	PAK6	Homo sapiens	Q9NQU5	Y2H Array	21988832
Cross	TPD52L1	Q16890	Tpd52	Mus musculus	Q62393	Y2H	9484778
Intra	TPD52L1	Q16890	YWHAB	Homo sapiens	P31946	CoIP	12963375
Intra	TPD52L1	Q16890	EIF3J	Homo sapiens	O75822	Y2H Pooling	16169070
Intra	TPD52L1	Q16890	YWHAZ	Homo sapiens	P63104	Pull Down	12963375
Intra	TPD52L1	Q16890	DAPK1	Homo sapiens	P53355	Protein Array	29513927
Intra	TPD52L1	Q16890	YWHAZ	Homo sapiens	P63104	Y2H	12963375

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14929	TPD52L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TPD52L1	MGD	MGI:1298386
Macaca mulatta	TPD52L1	VGNC	VGNC:78632
Felis catus	TPD52L1	VGNC	VGNC:66471
Canis familiaris	TPD52L1	VGNC	VGNC:47734
Rattus norvegicus	TPD52L1	RGD	RGD:1594796
Bos taurus	TPD52L1	VGNC	VGNC:36245

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