2. Gene
  3. MISP - mitotic spindle positioning Gene

MISP - mitotic spindle positioning Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MISP1; C19orf21

Gene ID: 126353 | Gene type: protein coding

About MISP

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:748,438-764,318 (from NCBI)

This gene has 2 transcripts (splice variants), 136 orthologues and 1 paralogue. Biased expression in small intestine (RPKM 92.0), duodenum (RPKM 77.1) and 6 other tissues.

Summary

The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016]

MISP Products(1)

mRNA Protein Name
NM_173481.4 NP_775752.1 mitotic interactor and substrate of PLK1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables actin filament binding IMP
IMP: Inferred from mutant phenotype
23509069 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23509069 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
23574715 GOA
involved in establishment of centrosome localization IMP
IMP: Inferred from mutant phenotype
23509069 GOA
involved in establishment of mitotic spindle orientation IMP
IMP: Inferred from mutant phenotype
23509069 GOA
involved in mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
23574715 GOA
involved in organelle localization IMP
IMP: Inferred from mutant phenotype
23574715 GOA
involved in regulation of protein localization to cell cortex IMP
IMP: Inferred from mutant phenotype
23509069 GOA
Cellular Component GO Annotation Evidence Reference Source
located in actin filament IMP
IMP: Inferred from mutant phenotype
23574715 GOA
colocalizes with cortical actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
23509069 GOA
colocalizes with focal adhesion IMP
IMP: Inferred from mutant phenotype
23509069 GOA
located in focal adhesion IMP
IMP: Inferred from mutant phenotype
23574715 GOA
colocalizes with mitotic spindle astral microtubule end IMP
IMP: Inferred from mutant phenotype
23509069 GOA
located in spindle pole centrosome IMP
IMP: Inferred from mutant phenotype
23574715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MISP Protein Structure

AKAP2_C

AKAP2_C: A-kinase anchor protein 2 C-terminus (325 - 674)

  • 0
  • 200
  • 400
  • 600
  • 679 a.a.
Protein Preferred Names Protein Names

mitotic interactor and substrate of PLK1

caprice

MISP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MISP Q8IVT2 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
Intra MISP Q8IVT2 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
Intra MISP Q8IVT2 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 DPH2 Homo sapiens Q9BQC3
Validated Y2H
32296183
Intra MISP Q8IVT2 DPH2 Homo sapiens Q9BQC3
Y2H Array
32296183
Intra MISP Q8IVT2 DPH2 Homo sapiens Q9BQC3
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra MISP Q8IVT2 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 RIBC1 Homo sapiens Q8N443
Y2H Array
32296183
Intra MISP Q8IVT2 RIBC1 Homo sapiens Q8N443
Validated Y2H
32296183
Intra MISP Q8IVT2 RIBC1 Homo sapiens Q8N443
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PPP1R16B Homo sapiens Q96T49
Validated Y2H
32296183
Intra MISP Q8IVT2 PPP1R16B Homo sapiens Q96T49
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PPP1R16B Homo sapiens Q96T49
Y2H Array
32296183
Intra MISP Q8IVT2 EZR Homo sapiens P15311
Anti Tag CoIP
28514442
Intra MISP Q8IVT2 EZR Homo sapiens P15311
Anti Tag CoIP
33961781
Intra MISP Q8IVT2 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra MISP Q8IVT2 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra MISP Q8IVT2 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra MISP Q8IVT2 ACTMAP Homo sapiens Q5BKX5-3
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 ACTMAP Homo sapiens Q5BKX5-3
Y2H Array
32296183
Intra MISP Q8IVT2 BOLL Homo sapiens Q8N9W6-4
Y2H Array
32296183
Intra MISP Q8IVT2 BOLL Homo sapiens Q8N9W6-4
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 BOLL Homo sapiens Q8N9W6-4
Validated Y2H
32296183
Intra MISP Q8IVT2 SPATC1L Homo sapiens Q9H0A9-2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 SPATC1L Homo sapiens Q9H0A9-2
Validated Y2H
32296183
Intra MISP Q8IVT2 SPATC1L Homo sapiens Q9H0A9-2
Y2H Array
32296183
Intra MISP Q8IVT2 MORN5 Homo sapiens Q5VZ52
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 MORN5 Homo sapiens Q5VZ52
Y2H Array
32296183
Intra MISP Q8IVT2 SOCS7 Homo sapiens O14512
Y2H Array
32296183
Intra MISP Q8IVT2 SOCS7 Homo sapiens O14512
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PRR5L Homo sapiens Q6MZQ0
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PRR5L Homo sapiens Q6MZQ0
Y2H Array
32296183
Intra MISP Q8IVT2 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra MISP Q8IVT2 SF3A2 Homo sapiens Q15428
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 SF3A2 Homo sapiens Q15428
Y2H Array
32296183
Intra MISP Q8IVT2 CRBN Homo sapiens Q96SW2
Validated Y2H
32296183
Intra MISP Q8IVT2 CRBN Homo sapiens Q96SW2
Y2H Array
32296183
Intra MISP Q8IVT2 CRBN Homo sapiens Q96SW2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra MISP Q8IVT2 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra MISP Q8IVT2 MAP1LC3C Homo sapiens Q9BXW4
Y2H Array
32296183
Intra MISP Q8IVT2 MAP1LC3C Homo sapiens Q9BXW4
Validated Y2H
32296183
Intra MISP Q8IVT2 MAP1LC3C Homo sapiens Q9BXW4
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 CDPF1 Homo sapiens Q6NVV7
Y2H Array
32296183
Intra MISP Q8IVT2 CDPF1 Homo sapiens Q6NVV7
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PNMA2 Homo sapiens Q9UL42
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PNMA2 Homo sapiens Q9UL42
Validated Y2H
32296183
Intra MISP Q8IVT2 PNMA2 Homo sapiens Q9UL42
Y2H Array
32296183
Intra MISP Q8IVT2 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra MISP Q8IVT2 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra MISP Q8IVT2 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra MISP Q8IVT2 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PIH1D1 Homo sapiens Q9NWS0
Y2H Array
32296183
Intra MISP Q8IVT2 PIH1D1 Homo sapiens Q9NWS0
Validated Y2H
32296183
Intra MISP Q8IVT2 PIH1D1 Homo sapiens Q9NWS0
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 VBP1 Homo sapiens P61758
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 VBP1 Homo sapiens P61758
Y2H Array
32296183
Intra MISP Q8IVT2 SPATS1 Homo sapiens Q496A3
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 SPATS1 Homo sapiens Q496A3
Y2H Array
32296183
Intra MISP Q8IVT2 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra MISP Q8IVT2 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TRIB3 Homo sapiens Q96RU7
Validated Y2H
32296183
Intra MISP Q8IVT2 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra MISP Q8IVT2 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra MISP Q8IVT2 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra MISP Q8IVT2 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra MISP Q8IVT2 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra MISP Q8IVT2 SNW1 Homo sapiens Q13573
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 SNW1 Homo sapiens Q13573
Y2H Array
32296183
Intra MISP Q8IVT2 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 FHL2 Homo sapiens Q14192
Y2H Array
32296183
Intra MISP Q8IVT2 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra MISP Q8IVT2 DPPA4 Homo sapiens Q7L190
Y2H Array
32296183
Intra MISP Q8IVT2 DPPA4 Homo sapiens Q7L190
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TERF1 Homo sapiens P54274-2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TERF1 Homo sapiens P54274-2
Y2H Array
32296183
Intra MISP Q8IVT2 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra MISP Q8IVT2 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra MISP Q8IVT2 HSPB8 Homo sapiens Q9UJY1
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 HSPB8 Homo sapiens Q9UJY1
Validated Y2H
32296183
Intra MISP Q8IVT2 HSPB8 Homo sapiens Q9UJY1
Y2H Array
32296183
Intra MISP Q8IVT2 HSPB2 Homo sapiens Q16082
Y2H Array
32296183
Intra MISP Q8IVT2 HSPB2 Homo sapiens Q16082
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra MISP Q8IVT2 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 CEP76 Homo sapiens Q8TAP6
Validated Y2H
32296183
Intra MISP Q8IVT2 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra MISP Q8IVT2 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra MISP Q8IVT2 ENKD1 Homo sapiens Q9H0I2
Y2H Array
32296183
Intra MISP Q8IVT2 ENKD1 Homo sapiens Q9H0I2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra MISP Q8IVT2 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra MISP Q8IVT2 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra MISP Q8IVT2 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra MISP Q8IVT2 LMO1 Homo sapiens P25800
Y2H Array
32296183
Intra MISP Q8IVT2 LMO1 Homo sapiens P25800
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 IRAK1BP1 Homo sapiens Q5VVH5
Y2H Array
32296183
Intra MISP Q8IVT2 IRAK1BP1 Homo sapiens Q5VVH5
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 MORN3 Homo sapiens Q6PF18
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 MORN3 Homo sapiens Q6PF18
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis Type 22

Als 22

Amyotrohpic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 22
Prostatic Adenoma

Prostatic Hyperplasia

Adenoma - Prostate

Adenoma Of Prostate

Benign Adenoma Of Prostate

Prostate Adenoma

Benign Prostatic Hyperplasia
Male Reproductive Organ Benign Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08465 MISP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08466 MISP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MISP VGNC VGNC:43246
Felis catus MISP VGNC VGNC:63519
Bos taurus MISP VGNC VGNC:31486
Rattus norvegicus MISP RGD RGD:1595680
Mus musculus MISP MGD MGI:1926156
Macaca mulatta MISP VGNC VGNC:74840