DZIP3 - DAZ interacting zinc finger protein 3 Gene

Homo sapiens

Also known as UURF2; PPP1R66; hRUL138

Gene ID: 9666 | Gene type: protein coding

About DZIP3

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,589,510-108,694,840 (from NCBI)

This gene has 6 transcripts (splice variants), 191 orthologues and 4 paralogues. Broad expression in testis (RPKM 21.6), brain (RPKM 12.1) and 21 other tissues.

Summary

Enables several functions, including Phosphatase binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin-protein transferase activity. Involved in protein polyubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DZIP3 Products(1)

mRNA	Protein	Name
NM_014648.4	NP_055463.1	E3 ubiquitin-protein ligase DZIP3

DZIP3 Protein Structure

zf-RING_2

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1208 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase DZIP3

DAZ interacting protein 3, zinc finger

DZIP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DZIP3	Q86Y13	HNRNPUL1	Homo sapiens	Q9BUJ2	Validated Y2H	32296183
Intra	DZIP3	Q86Y13	UBE2E2	Homo sapiens	Q96LR5	Y2H Array	19549727
Intra	DZIP3	Q86Y13	FBXO17	Homo sapiens	Q96EF6	Validated Y2H	32296183
Intra	DZIP3	Q86Y13	TIAL1	Homo sapiens	Q01085	Anti Tag CoIP	28514442
Intra	DZIP3	Q86Y13	TIAL1	Homo sapiens	Q01085	Anti Tag CoIP	33961781
Intra	DZIP3	Q86Y13	ARHGAP32	Homo sapiens	A7KAX9	Y2H Array	25416956
Intra	DZIP3	Q86Y13	ARHGAP32	Homo sapiens	A7KAX9	Y2H Prey Pooling	25416956
Intra	DZIP3	Q86Y13	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
Intra	DZIP3	Q86Y13	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	25416956
Intra	DZIP3	Q86Y13	AP1M1	Homo sapiens	Q9BXS5	Y2H Array	25416956
Intra	DZIP3	Q86Y13	ZCCHC10	Homo sapiens	Q8TBK6	Validated Y2H	25416956
Intra	DZIP3	Q86Y13	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Array	31515488
Intra	DZIP3	Q86Y13	ZNF24	Homo sapiens	P17028	Validated Y2H	25416956
Intra	DZIP3	Q86Y13	ZNF24	Homo sapiens	P17028	Y2H Array	31515488
Intra	DZIP3	Q86Y13	RBM4B	Homo sapiens	Q9BQ04	Y2H Array	25416956
Intra	DZIP3	Q86Y13	RBM4B	Homo sapiens	Q9BQ04	Validated Y2H	25416956
Intra	DZIP3	Q86Y13	CEP63	Homo sapiens	Q96MT8	Validated Y2H	25416956
Intra	DZIP3	Q86Y13	CEP63	Homo sapiens	Q96MT8	Y2H Array	25416956
Intra	DZIP3	Q86Y13	TOLLIP	Homo sapiens	Q9H0E2	Anti Tag CoIP	21903422
Intra	DZIP3	Q86Y13	GTF2H2C	Homo sapiens	Q6P1K8	Y2H Prey Pooling	25416956
Intra	DZIP3	Q86Y13	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	DZIP3	Q86Y13	ZNF765	Homo sapiens	Q7L2R6	Y2H Prey Pooling	25416956
Intra	DZIP3	Q86Y13	ZNF765	Homo sapiens	Q7L2R6	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04109	DZIP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DZIP3	VGNC	VGNC:61693
Rattus norvegicus	DZIP3	RGD	RGD:1563278
Bos taurus	DZIP3	VGNC	VGNC:28285
Mus musculus	DZIP3	MGD	MGI:1917433
Macaca mulatta	DZIP3	VGNC	VGNC:72019
Canis familiaris	DZIP3	VGNC	VGNC:40163

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