ZYX - zyxin Gene

Homo sapiens

Also known as ESP-2; HED-2

Gene ID: 7791 | Gene type: protein coding

About ZYX

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,381,345-143,391,111 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 181 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 122.6), lung (RPKM 100.3) and 25 other tissues.

Summary

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin Cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

ZYX Products(3)

mRNA	Protein	Name
NM_001010972.2	NP_001010972.1	zyxin isoform 1
NM_001362783.2	NP_001349712.1	zyxin isoform 2
NM_003461.5	NP_003452.1	zyxin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10801818	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24036928	GOA
involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	24036928	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24036928	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	8940160	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	12417594	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24036928	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	18297730	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZYX Protein Structure

LIM

0
100
200
300
400
500
572 a.a.

Protein Preferred Names

Protein Names

zyxin

zyxin-2

Recombinant ZYX Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71673	ZYX Protein, Human (HEK293, His)	Q15942 (A2-T572)	≥95%

Related Diseases

Diseases

Alias

Lipomatosis, Multiple

Lipoma	Familial Multiple Lipomatosis
Lipomatosis, Familial Multiple	Benign Lipomatous Tumor
Lipomatous Neoplasm	Multiple Lipomatosis
Fml	Lipo
Benign Tumor Of Adipose Tissue	Lipomatous Tumor
Tumor Of Adipose Tissue	Neoplasms, Adipose Tissue
Lipomas

Arrhythmogenic Right Ventricular Dysplasia, Familial, 10

Arrhythmogenic Right Ventricular Dysplasia 10	ARVD10
Arrhythmogenic Right Ventricular Cardiomyopathy 10	Arvc10
Familial Arrhythmogenic Right Ventricular Dysplasia 10	Dysplasia, Ventricular, Right, Arrhythmogenic, Type 10

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N12761	Penpaxilloids A	Inhibitor	/	Unkown
HY-RS16215	ZYX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZYX	VGNC	VGNC:51838
Felis catus	ZYX	VGNC	VGNC:67394
Mus musculus	ZYX	MGD	MGI:103072
Bos taurus	ZYX	VGNC	VGNC:37395
Macaca mulatta	ZYX	VGNC	VGNC:78917
Rattus norvegicus	ZYX	RGD	RGD:620698
Others	ZYX	NCBI

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