1. Gene
  2. PRRG4 - proline rich and Gla domain 4 Gene

PRRG4 - proline rich and Gla domain 4 Gene

Homo sapiens

Also known as TMG4; PRGP4

Gene ID: 79056 | Gene type: protein coding

About PRRG4

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:32,829,789-32,858,120 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues and 3 paralogues. Broad expression in esophagus (RPKM 11.6), skin (RPKM 9.5) and 18 other tissues.

Summary

Enables WW domain binding activity. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PRRG4 Products(1)

mRNA Protein Name
NM_024081.6 NP_076986.1 transmembrane gamma-carboxyglutamic acid protein 4 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables WW domain binding IDA
IDA: Inferred from direct assay
23873930 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23873930 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
23873930 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRRG4 Protein Structure

Gla

Gla: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (57 - 97)

  • 0
  • 100
  • 200
  • 226 a.a.
Protein Preferred Names Protein Names

transmembrane gamma-carboxyglutamic acid protein 4

proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)

PRRG4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PRRG4 Q9BZD6 YAP1 Homo sapiens P46937
Peptide Array
23873930
Intra PRRG4 Q9BZD6 YAP1 Homo sapiens P46937
Anti Tag CoIP
33961781
Intra PRRG4 Q9BZD6 YAP1 Homo sapiens P46937-1
Pull Down
23873930
Intra PRRG4 Q9BZD6 MAGI3 Homo sapiens Q5TCQ9
Pull Down
23873930
Intra PRRG4 Q9BZD6 MAGI3 Homo sapiens Q5TCQ9
Peptide Array
23873930
Intra PRRG4 Q9BZD6 YAP1 Homo sapiens P46937-3
Pull Down
23873930
Intra PRRG4 Q9BZD6 YAP1 Homo sapiens P46937-3
Anti Tag CoIP
23873930
Intra PRRG4 Q9BZD6 NEDD4L Homo sapiens Q96PU5
Peptide Array
23873930
Intra PRRG4 Q9BZD6 NEDD4L Homo sapiens Q96PU5
Anti Tag CoIP
33961781
Intra PRRG4 Q9BZD6 NEDD4L Homo sapiens Q96PU5
Pull Down
23873930
Intra PRRG4 Q9BZD6 NEDD4 Homo sapiens P46934
Anti Tag CoIP
33961781
Intra PRRG4 Q9BZD6 NEDD4 Homo sapiens P46934
Pull Down
23873930
Intra PRRG4 Q9BZD6 NEDD4 Homo sapiens P46934
Peptide Array
23873930
Cross PRRG4 Q9BZD6 Magi1 Mus musculus Q6RHR9-1
Anti Tag CoIP
23873930
Cross PRRG4 Q9BZD6 Magi1 Mus musculus Q6RHR9-1
Pull Down
23873930
Intra PRRG4 Q9BZD6 WWTR1 Homo sapiens Q9GZV5
Anti Tag CoIP
23873930
Intra PRRG4 Q9BZD6 WWTR1 Homo sapiens Q9GZV5
Pull Down
23873930
Intra PRRG4 Q9BZD6 WWTR1 Homo sapiens Q9GZV5
Peptide Array
23873930
Intra PRRG4 Q9BZD6 MAGI1 Homo sapiens Q96QZ7
Anti Tag CoIP
33961781
Intra PRRG4 Q9BZD6 MAGI1 Homo sapiens Q96QZ7
Peptide Array
23873930
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

Wagr Syndrome

11p Partial Monosomy Syndrome

Chromosome 11p13 Deletion Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome

11p Deletion Syndrome

Chromosome 11p Deletion Syndrome

Wagr Complex

Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome

Deletion 11p13

WAGR

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome

Chromosome 11p Deletion

11p Deletion

11p Monosomy

Deletion 11p

Monosomy 11p

Partial Monosomy 11p

Agr Triad

Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome

Wagr Contiguous Gene Syndrome

Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome

Del(11)(P13)

Monosomy 11p13

Chromosome 11, Deletion 11p

Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 1

VKCFD1

Combined Deficiency Of Vitamin K-Dependent Clotting Factors 1

Vitamin K-Dependent Coagulation Defect

Multiple Coagulation Factor Deficiency Iii

Mcfd3

Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 1

Vkcfd

Familial Multiple Coagulation Factor Deficiency Iii

Fmfd Iii

Factors Ii, Vii, Ix, And X, Combined Deficiency Of

Glutamic Acid, Deficient Gamma-Carboxylation Of

Hereditary Combined Deficiency Of Vitamin K-Dependent Clotting Factors

Hereditary Combined Deficiency Of Factors Ii, Vii, Ix And X

Vkcfd

Meckel Syndrome, Type 7

Meckel Syndrome 7

Nphp3-Related Meckel-Like Syndrome

MKS7

Goldston Syndrome

Meckel Syndrome Type 7

Meckel-Like Syndrome Type 1

Renal-Hepatic-Pancreatic Dysplasia-Dandy-Walker Cysts Syndrome

Renal Hepatic Pancreatic Dysplasia Dandy Walker Cyst

Renal-Hepatic-Pancreatic Dysplasia With Dandy-Walker Cyst

Meckel-Gruber Syndrome, Type 7

Dandy-Walker Cyst With Renal-Hepatic-Pancreatic Dysplasia

Aniridia 1

Aniridia

Congenital Aniridia

AN1

An

Cataract With Late-Onset Corneal Dystrophy

Aplasia Of Iris

Absent Iris

Irideremia

Aniridia Ii, Formerly

An2, Formerly

An2

Aniridia Type Ii

Aniridia, Type 1

An-1

Absence Of Iris

Agenesis Of Iris

Congenital Absence Of Iris

Hereditary Aniridia

Sporadic Aniridia

Iris Disease

Iris Diseases

Gillespie Syndrome

GLSP

Aniridia, Cerebellar Ataxia And Mental Deficiency

Aniridia Cerebellar Ataxia Mental Deficiency

Aniridia, Cerebellar Ataxia, And Mental Retardation

Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome

Aniridia-Cerebellar Ataxia-Intellectual Disability

Aniridia-Cerebellar Ataxia-Mental Deficiency

Partial Aniridia-Cerebellar Ataxia-Oligophrenia

Aniridia, Cerebellar Ataxia, And Intellectual Disability

Coloboma Of Optic Nerve

Morning Glory Disc Anomaly

Coloboma Of Optic Disc

Morning Glory Syndrome

Ectasic Coloboma

Coloboma Of Optic Papilla

Congenital Coloboma Of The Optic Nerve

Optic Nerve Coloboma

Optic Nerve Head Pits, Bilateral Congenital

Volubilis Syndrome

COLON

Coloboma Of Optic Disc, Unspecified Eye

Congenital Coloboma Of Optic Disc

Optic Disk Coloboma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta PRRG4 VGNC VGNC:107629
Bos taurus PRRG4 VGNC VGNC:33409
Rattus norvegicus PRRG4 RGD RGD:1560542
Canis familiaris PRRG4 VGNC VGNC:45058
Felis catus PRRG4 VGNC VGNC:64393
Mus musculus PRRG4 MGD MGI:2442211