NEDD4 - NEDD4 E3 ubiquitin protein ligase Gene

Homo sapiens

Also known as RPF1; NEDD4-1

Gene ID: 4734 | Gene type: protein coding

About NEDD4

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:55,826,917-55,993,612 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 24 paralogues. Ubiquitous expression in placenta (RPKM 6.4), liver (RPKM 5.9) and 23 other tissues.

Summary

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin Proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin Ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

NEDD4 Products(6)

mRNA	Protein	Name
NM_001284338.2	NP_001271267.1	E3 ubiquitin-protein ligase NEDD4 isoform 3
NM_001284339.1	NP_001271268.1	E3 ubiquitin-protein ligase NEDD4 isoform 4
NM_001284340.1	NP_001271269.1	E3 ubiquitin-protein ligase NEDD4 isoform 5
NM_001329212.2	NP_001316141.1	E3 ubiquitin-protein ligase NEDD4 isoform 6
NM_006154.4	NP_006145.2	E3 ubiquitin-protein ligase NEDD4 isoform 1
NM_198400.3	NP_940682.2	E3 ubiquitin-protein ligase NEDD4 isoform 2

NEDD4 Protein Structure

HECT

0
300
600
900
1200
1319 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase NEDD4

HECT-type E3 ubiquitin transferase NEDD4

NEDD4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NEDD4	P46934	FGFR1	Homo sapiens	P11362	Pull Down	21765395
Intra	NEDD4	P46934	FGFR1	Homo sapiens	P11362	Peptide Array	21765395
Intra	NEDD4	P46934	FGFR1	Homo sapiens	P11362	FPS	21765395
Intra	NEDD4	P46934	MLANA	Homo sapiens	Q16655	Phage Display	37219487
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	FPS	39009827
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	Pull Down	21765395
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	Peptide Array	21765395
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	Far-WB	11359767
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	Phage Display	39009827
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	FPS	21765395
Intra	NEDD4	P46934	PIP4P2	Homo sapiens	Q8N4L2	Phage Display	37219487
Intra	NEDD4	P46934	UVRAG	Homo sapiens	Q9P2Y5	Phage Display	37219487
Intra	NEDD4	P46934	UVRAG	Homo sapiens	Q9P2Y5	Phage Display	35044719
Intra	NEDD4	P46934	MS4A10	Homo sapiens	Q96PG2	Phage Display	35044719
Intra	NEDD4	P46934	TRERF1	Homo sapiens	Q96PN7	Phage Display	37219487
Intra	NEDD4	P46934	TRERF1	Homo sapiens	Q96PN7	Phage Display	35044719
Intra	NEDD4	P46934	YWHAE	Homo sapiens	P62258	TAP	24981860
Intra	NEDD4	P46934	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	NEDD4	P46934	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	NEDD4	P46934	TP73	Homo sapiens	O15350	Phage Display	37219487
Intra	NEDD4	P46934	TP73	Homo sapiens	O15350	Phage Display	35044719
Intra	NEDD4	P46934	PRRG4	Homo sapiens	Q9BZD6	Phage Display	37219487
Intra	NEDD4	P46934	PRRG4	Homo sapiens	Q9BZD6	Phage Display	35044719
Intra	NEDD4	P46934	PRR7	Homo sapiens	Q8TB68	Anti Tag CoIP	33961781
Intra	NEDD4	P46934	PRR7	Homo sapiens	Q8TB68	Phage Display	35044719
Intra	NEDD4	P46934	RNF11	Homo sapiens	Q9Y3C5	Phage Display	35044719
Intra	NEDD4	P46934	RNF11	Homo sapiens	Q9Y3C5	FPS	37100772
Intra	NEDD4	P46934	UBB	Homo sapiens	P0CG47	TAP	24981860
Intra	NEDD4	P46934	PTEN	Homo sapiens	P60484	Pull Down	19345329
Intra	NEDD4	P46934	PTEN	Homo sapiens	P60484	Anti Bait CoIP	19345329
Intra	NEDD4	P46934	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	NEDD4	P46934	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	NEDD4	P46934	LITAF	Homo sapiens	Q99732	IF	16118794
Intra	NEDD4	P46934	LITAF	Homo sapiens	Q99732	Anti Bait CoIP	16118794
Intra	NEDD4	P46934	TMEM51	Homo sapiens	Q9NW97	Phage Display	37219487
Intra	NEDD4	P46934	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	NEDD4	P46934	SCNN1A	Homo sapiens	P37088	Far-WB	11359767
Intra	NEDD4	P46934	SCNN1A	Homo sapiens	P37088	Pull Down	11359767
Intra	NEDD4	P46934	SCNN1A	Homo sapiens	P37088	NMR	23665454
Intra	NEDD4	P46934	ENTREP1	Homo sapiens	Q15884	Phage Display	35044719
Intra	NEDD4	P46934	LDLRAD4	Homo sapiens	O15165	Phage Display	35044719
Cross	NEDD4	P46934	UL56	Human herpesvirus 2	P28282	FPS	37100772
Cross	NEDD4	P46934	VP40	Sudan ebolavirus	Q5XX06	FPS	37100772
Cross	NEDD4	P46934	VP40	Sudan ebolavirus	Q5XX06	Phage Display	37100772

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Liddle Syndrome 1

Liddle Syndrome	Pseudoaldosteronism
Liddle'S Syndrome	LIDLS1
Lidls	Pseudohyperaldosteronism
Pseudoprimary Hyperaldosteronism	Pseudohyperaldosteronism Type 1
Liddles Syndrome

Pseudohypoaldosteronism

Keloid Formation

KLDF

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome	Pten Hamartoma Tumor Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Pten Hamartoma Tumor Syndromes
Cowden Syndrome, Type 1

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Spinocerebellar Ataxia 31

Spinocerebellar Ataxia Type 31	SCA31
Spinocerebellar Ataxia 16q22-Linked	Spinocerebellar Ataxia, 16q22-Linked
Pure Spinocerebellar Ataxia Japanese Type	Sca4 Pure Japanese Type
Ataxia, Spinocerebellar, Type 31

Charcot-Marie-Tooth Disease, Demyelinating, Type 1c

Charcot-Marie-Tooth Disease Type 1c	CMT1C
Hmsn1c	Hmsn Ic
Charcot-Marie-Tooth Disease, Type 1c	Charcot-Marie-Tooth Neuropathy Type 1c
Cmt, Slow Nerve Conduction Type C	Charcot-Marie-Tooth Neuropathy, Type 1c
Neuropathy, Hereditary Motor And Sensory, Type Ic	Cmt Slow Nerve Conduction Type C
Neuropathy Hereditary Motor And Sensory Type 1c	Charcot-Marie-Tooth Disease 1c
Charcot-Marie-Tooth Disease Demyelinating Type 1c	Hereditary Motor And Sensory Neuropathy Ic
Charcot-Marie-Tooth Disease, Type Ic

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110204	Heclin	Inhibitor	98.21%	Unkown
HY-134417	NSC2805	Inhibitor	98.08%	Unkown
HY-153178	HECT E3-IN-1	Inhibitor	99.43%	Unkown
HY-110174	NAB2		99.69%	Unkown
HY-162809	XMU-MP-9		98.16%	Unkown
HY-122046	Amb123203		/	Unkown
HY-RS09179	NEDD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09180	NEDD4L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N10159	1-Benzyl-I3C		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NEDD4	VGNC	VGNC:59121
Rattus norvegicus	NEDD4	RGD	RGD:3157
Macaca mulatta	NEDD4	VGNC	VGNC:75302
Bos taurus	NEDD4	VGNC	VGNC:55128
Mus musculus	NEDD4	MGD	MGI:97297
Felis catus	NEDD4	VGNC	VGNC:80898
Others	NEDD4	NCBI

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