Hpgd - 15-hydroxyprostaglandin dehydrogenase Gene

Rattus norvegicus

Gene ID: 79242 | Gene type: protein coding

About Hpgd

Primary_assembly 16: 33,986,266-34,024,228 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 204 orthologues and is associated with 16 phenotypes. Biased expression in Lung (RPKM 31.9), Kidney (RPKM 262.4) and 5 other tissues.

Summary

Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity and identical protein binding activity. Involved in several processes, including positive regulation of vascular associated smooth muscle cell proliferation; prostaglandin metabolic process; and thrombin-activated receptor signaling pathway. Located in cytoplasm and extracellular space. Used to study carcinoma. Biomarker of peptic ulcer disease. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Hpgd Products(1)

mRNA	Protein	Name
NM_024390.3	NP_077366.2	15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	9099857	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	2251293	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in female pregnancy	IEP IEP: Inferred from expression pattern	3338612	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	24647712	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	22580984	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	24657469	RGD
involved in prostaglandin metabolic process	IDA IDA: Inferred from direct assay	18058808	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	3478736	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	6574558	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	12399253	RGD
involved in thrombin-activated receptor signaling pathway	IEP IEP: Inferred from expression pattern	19383433	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	24647712	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hpgd Protein Structure

ADH_SDR_c_like

0
100
200
266 a.a.

Protein Preferred Names

Protein Names

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

15-PGDH	NAD-dependent 15-hydroxyprostaglandin dehydrogenase
PGDH	eicosanoid/docosanoid dehydrogenase
hydroxyprostaglandin dehydrogenase 15 (NAD)	prostaglandin dehydrogenase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108259	HQL-79	Inhibitor	99.89%	Unkown
HY-12791	hPGDS-IN-1	Inhibitor	99.92%	Unkown
HY-110167	TFC 007	Inhibitor	98.01%	Unkown
HY-139972	PROTAC(H-PGDS)-7		99.42%	Unkown
HY-10439	HPGDS inhibitor 1	Inhibitor	99.04%	Unkown
HY-109134	Pizuglanstat	Inhibitor	99.70%	Unkown
HY-126134	HPGDS inhibitor 2	Inhibitor	99.72%	Unkown
HY-146662	HPGDS inhibitor 3	Inhibitor	/	Unkown
HY-157577	PROTAC(H-PGDS)-8	Degrader	/	Unkown
HY-RS06338	HPGD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06339	Hpgd Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06340	Hpgd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06341	HPGDS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-109134A	Pizuglanstat hydrate	Inhibitor	/	Unkown
HY-120581	ML388	Inhibitor	/	Unkown
HY-139171	F092	Inhibitor	99.79%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hpgd	NCBI	NCBI:3248
Mus musculus	Hpgd	NCBI	NCBI:15446

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