2. Gene
  3. BIRC7 - baculoviral IAP repeat containing 7 Gene

BIRC7 - baculoviral IAP repeat containing 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KIAP; LIVIN; MLIAP; RNF50; ML-IAP

Gene ID: 79444 | Gene type: protein coding

About BIRC7

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,235,905-63,240,495 (from NCBI)

This gene has 3 transcripts (splice variants), 156 orthologues and 7 paralogues. Biased expression in placenta (RPKM 3.1), skin (RPKM 0.7) and 5 other tissues.

Summary

This gene encodes a member of the inhibitor of Apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit Apoptosis alone. Elevated levels of the encoded protein may be associated with Cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]

BIRC7 Products(2)

mRNA Protein Name
NM_022161.4 NP_071444.1 baculoviral IAP repeat-containing protein 7 isoform beta
NM_139317.3 NP_647478.1 baculoviral IAP repeat-containing protein 7 isoform alpha
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11024045 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
16729033 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16729033 GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
11865055 GOA
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
11865055 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
16729033 GOA
acts upstream of negative effect regulation of apoptotic process IDA
IDA: Inferred from direct assay
11865055 GOA
involved in regulation of cell population proliferation IDA
IDA: Inferred from direct assay
21617971 GOA
involved in regulation of natural killer cell apoptotic process IDA
IDA: Inferred from direct assay
18034418 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17294084 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17294084 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17294084 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BIRC7 Protein Structure

BIR

BIR: Inhibitor of Apoptosis domain (90 - 154)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (249 - 291)

  • 0
  • 100
  • 200
  • 298 a.a.
Protein Preferred Names Protein Names

baculoviral IAP repeat-containing protein 7

RING finger protein 50

BIRC7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BIRC7 Q96CA5 BOLA1 Homo sapiens Q9Y3E2
Validated Y2H
32296183
Intra
BIRC7 Q96CA5 POLR1C Homo sapiens O15160
Y2H Prey Pooling
25416956
Intra
BIRC7 Q96CA5 POLR1C Homo sapiens O15160
Validated Y2H
25416956
Intra
BIRC7 Q96CA5 LCOR Homo sapiens Q96JN0-2
Validated Y2H
32296183
Intra
BIRC7 Q96CA5 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra
BIRC7 Q96CA5 DDX6 Homo sapiens P26196
Y2H Array
25416956
Intra
BIRC7 Q96CA5 AURKC Homo sapiens Q9UQB9
Validated Y2H
32296183
Intra
BIRC7 Q96CA5 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra
BIRC7 Q96CA5 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra
BIRC7 Q96CA5 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra
BIRC7 Q96CA5 BIRC2 Homo sapiens Q13490
Anti Tag CoIP
33961781
Intra
BIRC7 Q96CA5 BIRC2 Homo sapiens Q13490
Anti Tag CoIP
28514442
Intra
BIRC7 Q96CA5 BIRC2 Homo sapiens Q13490
Y2H Array
31515488
Intra
BIRC7 Q96CA5 BIRC2 Homo sapiens Q13490
Y2H Prey Pooling
25416956
Intra
BIRC7 Q96CA5 BIRC2 Homo sapiens Q13490
Validated Y2H
25416956
Intra
BIRC7 Q96CA5 CASP9 Homo sapiens P55211
Y2H Prey Pooling
25416956
Intra
BIRC7 Q96CA5 CASP9 Homo sapiens P55211
Anti Tag CoIP
11801603
Intra
BIRC7 Q96CA5 CASP9 Homo sapiens P55211
CoIP
11024045
Intra
BIRC7 Q96CA5 CASP9 Homo sapiens P55211
Pull Down
11801603
Intra
BIRC7 Q96CA5 HTRA2 Homo sapiens O43464
Anti Tag CoIP
33961781
Intra
BIRC7 Q96CA5 HTRA2 Homo sapiens O43464
FPS
11801603
Intra
BIRC7 Q96CA5 HTRA2 Homo sapiens O43464
Pull Down
11801603
Intra
BIRC7 Q96CA5 DIABLO Homo sapiens Q9NR28
Pull Down
11801603
Intra
BIRC7 Q96CA5 DIABLO Homo sapiens Q9NR28
Anti Tag CoIP
11801603
Intra
BIRC7 Q96CA5 DIABLO Homo sapiens Q9NR28
Anti Tag CoIP
33961781
Intra
BIRC7 Q96CA5 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
BIRC7 Q96CA5 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra
BIRC7 Q96CA5 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
BIRC7 Q96CA5 FAM124B Homo sapiens Q9H5Z6
Y2H Prey Pooling
25416956
Intra
BIRC7 Q96CA5 FAM124B Homo sapiens Q9H5Z6
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BIRC7 Proteins

Cat. No. Product Name Accession Purity
HY-P77065 Livin/BIRC7 Protein, Human (His) Q96CA5-1 (M1-S298) ≥95%

Related Diseases

Diseases Alias
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50685 A 410099.1 Inhibitor 99.30% Unkown
HY-RS01515 BIRC7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BIRC7 VGNC VGNC:60119
Mus musculus BIRC7 MGD MGI:2676458
Macaca mulatta BIRC7 VGNC VGNC:70302
Canis familiaris BIRC7 VGNC VGNC:38463
Bos taurus BIRC7 VGNC VGNC:26503
Rattus norvegicus BIRC7 RGD RGD:1562883
Others BIRC7 NCBI