THOC7 - THO complex subunit 7 Gene

Homo sapiens

Also known as fSAP24; hTREX30; NIF3L1BP1

Gene ID: 80145 | Gene type: protein coding

About THOC7

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:63,833,870-63,864,484 (from NCBI)

This gene has 7 transcripts (splice variants) and 238 orthologues. Ubiquitous expression in adrenal (RPKM 20.0), colon (RPKM 19.8) and 25 other tissues.

Summary

Predicted to enable RNA binding activity. Involved in mRNA export from nucleus and viral mRNA export from host cell nucleus. Located in cytosol and nuclear speck. Part of THO complex part of transcription export complex. Colocalizes with chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]

THOC7 Products(3)

mRNA	Protein	Name
NM_001285387.3	NP_001272316.1	THO complex subunit 7 homolog isoform 2
NM_001285404.2	NP_001272333.1	THO complex subunit 7 homolog isoform 2
NM_025075.4	NP_079351.2	THO complex subunit 7 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12951069	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA export from nucleus	IDA IDA: Inferred from direct assay	17190602	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of THO complex	IDA IDA: Inferred from direct assay	15998806	GOA
part of THO complex part of transcription export complex	IDA IDA: Inferred from direct assay	15998806	GOA
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12951069	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12951069	GOA
part of transcription export complex	IDA IDA: Inferred from direct assay	15833825	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THOC7 Protein Structure

THOC7

0
100
204 a.a.

Protein Preferred Names

Protein Names

THO complex subunit 7 homolog

NIF3L1-binding protein 1

THOC7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	THOC7	Q6I9Y2	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	THOC7	Q6I9Y2	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	THOC7	Q6I9Y2	THOC5	Homo sapiens	Q13769	Anti Tag CoIP	26496610
Intra	THOC7	Q6I9Y2	THOC5	Homo sapiens	Q13769	Anti Tag CoIP	19059247
Intra	THOC7	Q6I9Y2	THOC5	Homo sapiens	Q13769	Pull Down	19059247
Intra	THOC7	Q6I9Y2	MNS1	Homo sapiens	Q8NEH6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ogden Syndrome

OGDNS	N-Terminal Acetyltransferase Deficiency
NATD	N-Alpha-Acetyltransferase
X-Linked Malformation And Infantile Lethality Syndrome	Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome

Microphthalmia, Syndromic 1

MCOPS1	Lenz Microphthalmia Syndrome
Lenz Dysplasia	Mcops4
Syndromic Microphthalmia 1	Lenz Microphthalmia
Maa	Microphthalmia Or Anophthalmos With Associated Anomalies
Syndromic Microphthalmia Type 4	Microphthalmia, Syndromic 4
Microphthalmia, Syndromic 4, Formerly	Mcops4, Formerly
Anop1, Formerly	Maa, Formerly
Lenz Type Microphthalmia	Syndromic Microphthalmia 4
Microphthalmia Lenz Type	Microphthalmia Syndromic 1
Syndromic Microphthalmia Type 1	Microphthalmia Syndromic 4
Microphthalmia With Ankyloblepharon And Intellectual Disability	Microphthalmia, Lenz Type
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome	Microphthalmia, Syndromic, 1
Anop1	Microphthalmia, Syndromic, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14496	THOC7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THOC7	VGNC	VGNC:79824
Rattus norvegicus	THOC7	RGD	RGD:1305475
Bos taurus	THOC7	VGNC	VGNC:106977
Felis catus	THOC7	VGNC	VGNC:66169
Mus musculus	THOC7	MGD	MGI:1913481
Canis familiaris	THOC7	VGNC	VGNC:58337

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