TAB2 - TGF-beta activated kinase 1 (MAP3K7) binding protein 2 Gene

Homo sapiens

Also known as CHTD2; TAB-2; MAP3K7IP2

Gene ID: 23118 | Gene type: protein coding

About TAB2

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,217,926-149,411,607 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 17.2), esophagus (RPKM 14.8) and 25 other tissues.

Summary

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

TAB2 Products(4)

mRNA	Protein	Name
NM_001292034.3	NP_001278963.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a
NM_001292035.3	NP_001278964.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform b
NM_001369506.1	NP_001356435.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a
NM_015093.6	NP_055908.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables K63-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	15327770	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	10882101	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11460167	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	22158122	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	18079694	GOA
involved in heart development	IMP IMP: Inferred from mutant phenotype	20493459	GOA
involved in inflammatory response	IDA IDA: Inferred from direct assay	36681779	GOA
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	33184450	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15327770	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11460167	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19193853	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	10882101	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAB2 Protein Structure

CUE

zf-RanBP

0
200
400
600
693 a.a.

Protein Preferred Names

Protein Names

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

TAK1-binding protein 2

TAB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TAB2	Q9NYJ8	KRT85	Homo sapiens	P78386	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	KRT85	Homo sapiens	P78386	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	TAB2	Q9NYJ8	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	CAMK2A	Homo sapiens	Q9UQM7	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	CAMK2A	Homo sapiens	Q9UQM7	Validated Y2H	32296183
Intra	TAB2	Q9NYJ8	CAMK2A	Homo sapiens	Q9UQM7	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	ZFP64	Homo sapiens	Q9NTW7-5	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	ZFP64	Homo sapiens	Q9NTW7-5	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	ZNF143	Homo sapiens	P52747	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	ZNF143	Homo sapiens	P52747	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	TPM3	Homo sapiens	P06753	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	TPM3	Homo sapiens	P06753	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	TAB1	Homo sapiens	Q15750	Y2H	21988832
Intra	TAB2	Q9NYJ8	TAB1	Homo sapiens	Q15750	Anti Tag CoIP	21903422
Intra	TAB2	Q9NYJ8	MAP3K7	Homo sapiens	O43318	Anti Bait CoIP	22081109
Intra	TAB2	Q9NYJ8	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	21903422
Intra	TAB2	Q9NYJ8	MAP3K7	Homo sapiens	O43318-2	TAP	14743216
Intra	TAB2	Q9NYJ8	TRAF6	Homo sapiens	Q9Y4K3	Anti Bait CoIP	19675569
Intra	TAB2	Q9NYJ8	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	ZBTB16	Homo sapiens	Q05516	Y2H	21988832
Intra	TAB2	Q9NYJ8	ZBTB16	Homo sapiens	Q05516	Confocal	21988832
Intra	TAB2	Q9NYJ8	ZBTB16	Homo sapiens	Q05516	Anti Tag CoIP	21988832
Intra	TAB2	Q9NYJ8	FOSL1	Homo sapiens	P15407	Y2H Array	21988832
Intra	TAB2	Q9NYJ8	FOSL1	Homo sapiens	P15407	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	FOSL1	Homo sapiens	P15407	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	BECN1	Homo sapiens	Q14457	Anti Tag CoIP	22081109
Intra	TAB2	Q9NYJ8	BECN1	Homo sapiens	Q14457	Pull Down	22081109
Intra	TAB2	Q9NYJ8	BECN1	Homo sapiens	Q14457	Y2H	22081109
Intra	TAB2	Q9NYJ8	BECN1	Homo sapiens	Q14457	Anti Bait CoIP	22081109

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Heart Defects, Multiple Types, 2

CHTD2	Congenital Heart Defects, Nonsyndromic, 2
Congenital Heart Defects Non-Syndromic 2

Polyvalvular Heart Disease Syndrome

Phd Syndrome

Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5	Latent Autoimmune Diabetes In Adults
IDDM5	Insulin-Dependent Diabetes Mellitus 5
T1D5	Lada
Type 1.5 Diabetes	Diabetes Mellitus, Insulin-Dependent, Type 5

Encephalopathy

Brain Diseases	Encephalopathies
Toxic Encephalopathy	Toxic Brain Fever
Toxic Brain Inflammation	Toxic Brain Stem Inflammation
Toxic Cerebral Fever	Toxic Cerebrospinal Fever
Toxic Cerebrospinal Inflammation	Encephalopathy Nec
Encephalopathy Nos	Encephalopathy Disease
Encephalopathy Syndrome

Pelvic Organ Prolapse

Rectal Prolapse	Pelvic Organ Prolapse, Susceptibility To, 1
Pelvic Organ Prolapse, Susceptibility To	Prolapse Of Vagina And Rectum
Vaginal Prolapse	Pelvic Organ Prolapse 1
Procidentia, Rectum	Prolapse Of Rectal Mucosa
Procidentia Of Rectum	Rectal Mucosa Prolapse
Rectum Prolapse	Procidentia Rectum
Rp - [Rectal Prolapse]	Male Proctocele
Male Rectocele	Proctoptosis
Female Genital Prolapse	Female Prolapse
Incompetence Of Pelvic Fundus	Relaxation Of Perineum
Deficiency Of Perineum

Atrial Septal Defect 2

ASD2	Atrial Heart Septal Defect 2
Atrial Septal Defect-2	Asd Ii
Septal Defect, Atrial, Type 2

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa	Foramen Ovale Patent
Ostium Secundum Atrial Septal Defect	Atrial Septal Defect, Ostium Secundum Type
Foramen Ovale, Patent	Defect, Patent Or Persistent, Ostium Secundum
Ostium Secundum Type Atrial Septal Defect	Persistent Ostium Secundum
Asd Ostium Secundum Type	Ostium Secundum Asd
Osasd	Asd, Ostium Secundum Type
Pfo - [Patent Foramen Ovale]	Open Foramen Ovale
Open Oval Foramen	Persistent Foramen Ovale
Secundum Atrial Septal Defect

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Frontometaphyseal Dysplasia

Fmd	Dysplasia, Frontometaphyseal

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Otopalatodigital Syndrome Spectrum Disorder

Opd Spectrum Disorder	Opsd
Fronto-Otopalatodigital Osteodysplasia

Ectodermal Dysplasia 10a, Hypohidrotic/Hair/Nail Type, Autosomal Dominant

ECTD10A	Hed
Ectodermal Dysplasia 10a	Ectodermal Dysplasia Hypohidrotic Autosomal Dominant
Autosomal Dominant Hypohidrotic Ectodermal Dysplasia	Ectodermal Dysplasia, Hypohidrotic, Autosomal Dominant
Hypohidrotic Ectodermal Dysplasia Autosomal Dominant	Ad-Hed
Autosomal Dominant Anhidrotic Ectodermal Dysplasia	Ectodermal Dysplasia 3
Ed3	Eda3
Ectodermal Dysplasia, Anhidrotic, Autosomal Dominant	Dysplasia, Ectodermal, Type 10a, Hypohidrotic/Hair/Nail, Autosomal Dominant
Dysplasia, Ectodermal, Type 3

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

Hypohidrotic Ectodermal Dysplasia	Hed
Anhidrotic Ectodermal Dysplasia	Ectodermal Dysplasia, Hypohidrotic
Eda	Christ-Siemens-Touraine Syndrome
ECTD10B	Ectodermal Dysplasia Anhidrotic
Ectodermal Dysplasia, Anhidrotic	Cst Syndrome
Ectodermal Dysplasia Hypohidrotic Autosomal Recessive	Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive
Dysplasia, Ectodermal, Hypohidrotic	Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive
Ectodermal Dysplasia 3, Anhidrotic	Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14134	TAB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TAB2	VGNC	VGNC:53809
Mus musculus	TAB2	MGD	MGI:1915902
Macaca mulatta	TAB2	VGNC	VGNC:83476
Canis familiaris	TAB2	VGNC	VGNC:53995
Felis catus	TAB2	VGNC	VGNC:102528
Rattus norvegicus	TAB2	RGD	RGD:1309527
Others	TAB2	NCBI

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