2. Gene
  3. CDT1 - chromatin licensing and DNA replication factor 1 Gene

CDT1 - chromatin licensing and DNA replication factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DUP; RIS2

Gene ID: 81620 | Gene type: protein coding

About CDT1

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:88,803,789-88,809,258 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and is associated with 3 phenotypes. Biased expression in bone marrow (RPKM 13.5), placenta (RPKM 2.5) and 9 other tissues.

Summary

The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]

CDT1 Products(1)

mRNA Protein Name
NM_030928.4 NP_112190.2 DNA replication factor Cdt1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
11125146 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11125146 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA replication checkpoint signaling IDA
IDA: Inferred from direct assay
14672932 GOA
involved in DNA replication preinitiation complex assembly IDA
IDA: Inferred from direct assay
11125146 GOA
involved in attachment of mitotic spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
22581055 GOA
involved in negative regulation of DNA-templated DNA replication IDA
IDA: Inferred from direct assay
19906994 GOA
involved in negative regulation of cell cycle IDA
IDA: Inferred from direct assay
19906994 GOA
involved in positive regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
26842564 GOA
involved in positive regulation of DNA-templated DNA replication IDA
IDA: Inferred from direct assay
11125146 GOA
involved in positive regulation of chromatin binding IDA
IDA: Inferred from direct assay
11125146 GOA
involved in regulation of DNA-templated DNA replication initiation IDA
IDA: Inferred from direct assay
11125146 GOA
involved in response to sorbitol IDA
IDA: Inferred from direct assay
21856198 GOA
Cellular Component GO Annotation Evidence Reference Source
located in kinetochore IDA
IDA: Inferred from direct assay
22581055 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11125146 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDT1 Protein Structure

CDT1

CDT1: DNA replication factor CDT1 like (186 - 350)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 546 a.a.
Protein Preferred Names Protein Names

DNA replication factor Cdt1

Double parked, Drosophila, homolog of

CDT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CDT1 Q9H211 PCNA Homo sapiens P12004
Pull Down
16482215
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
Peptide Array
15232106
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
Pull Down
11125146
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
BFG-2H
27107012
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
Pull Down
19906994
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
CoIP
11125146
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
Pull Down
16482215
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
X-Ray Diffraction
19906994
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
SAXS
19906994
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
Y2H
22581055
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
GMS
19906994
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
Anti Tag CoIP
21543332
Intra
CDT1 Q9H211 GMNN Homo sapiens O75496
SPR
19906994
Intra
CDT1 Q9H211 CDC6 Homo sapiens Q99741
Pull Down
14672932
Intra
CDT1 Q9H211 MCM6 Homo sapiens Q14566
Anti Tag CoIP
26496610
Intra
CDT1 Q9H211 MCM6 Homo sapiens Q14566
NMR
20202939
Intra
CDT1 Q9H211 NDC80 Homo sapiens O14777
Pull Down
22581055
Intra
CDT1 Q9H211 NDC80 Homo sapiens O14777
Anti Bait CoIP
22581055
Intra
CDT1 Q9H211 NDC80 Homo sapiens O14777
Y2H
22581055
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Meier-Gorlin Syndrome 4

MGORS4

Meier-Gorlin Syndrome, Type 4
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Genitourinary Tract Anomalies
Microtia

Congenital Small Ears

Hypoplasia Of Ear
Meier-Gorlin Syndrome 7

MGORS7

Meier-Gorlin Syndrome, Type 7
Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5
Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia

Primordial Dwarfism

Isolated Growth Hormone Deficiency Type Ia

Sexual Ateleiotic Dwarfism

Pituitary Dwarfism I

IGHD1A

Illig-Type Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, Type Ia

Congenital Ighd Type Ia

Congenital Isolated Gh Deficiency Type Ia

Congenital Isolated Growth Hormone Deficiency Type Ia

Pituitary Dwarfism 1

Growth Hormone Deficiency, Isolated, Autosomal Recessive

Autosomal Recessive Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 1a

Congenital Ighd

Congenital Isolated Gh Deficiency

Congenital Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated Autosomal Recessive

Illig Type Growth Hormone Deficiency

Non-Acquired Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, 1a

Growth Hormone Deficiency Isolated Autosomal Recessive

Dwarfism, Primordial

Dwarfism
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02427 CDT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDT1 VGNC VGNC:27158
Canis familiaris CDT1 VGNC VGNC:39083
Macaca mulatta CDT1 VGNC VGNC:71092
Felis catus CDT1 VGNC VGNC:60721
Rattus norvegicus CDT1 RGD RGD:1309211
Mus musculus CDT1 MGD MGI:1914427