GMNN - geminin DNA replication inhibitor Gene

Homo sapiens

Also known as Gem; MGORS6

Gene ID: 51053 | Gene type: protein coding

About GMNN

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,774,937-24,786,099 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 7.1), testis (RPKM 5.6) and 25 other tissues.

Summary

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast Cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

GMNN Products(4)

mRNA	Protein	Name
NM_001251989.2	NP_001238918.1	geminin
NM_001251990.2	NP_001238919.1	geminin
NM_001251991.1	NP_001238920.1	geminin
NM_015895.5	NP_056979.1	geminin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	11125146	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16924111	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11125146	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA replication preinitiation complex assembly	IDA IDA: Inferred from direct assay	11125146	GOA
involved in negative regulation of DNA replication	IDA IDA: Inferred from direct assay	9635433	GOA
involved in negative regulation of DNA-templated DNA replication	IDA IDA: Inferred from direct assay	11125146	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16924111	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	9635433	GOA
involved in positive regulation of chromatin binding	IDA IDA: Inferred from direct assay	11125146	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	17234884	GOA
involved in regulation of DNA-templated DNA replication initiation	IDA IDA: Inferred from direct assay	24064211	GOA
involved in regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	21543332	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21543332	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21543332	GOA
part of transcription repressor complex	IPI IPI: Inferred from physical interaction	22615398	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMNN Protein Structure

Geminin

0
100
209 a.a.

Protein Preferred Names

Protein Names

geminin

GMNN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GMNN	O75496	ZNF250	Homo sapiens	P15622-3	Validated Y2H	32296183
Intra	GMNN	O75496	CCDC146	Homo sapiens	Q8IYE0-2	Validated Y2H	25416956
Intra	GMNN	O75496	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Array	25416956
Intra	GMNN	O75496	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Prey Pooling	25416956
Intra	GMNN	O75496	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	GMNN	O75496	PTPN11	Homo sapiens	Q06124-2	Validated Y2H	32296183
Intra	GMNN	O75496	HOXC9	Homo sapiens	P31274	ITC	22615398
Intra	GMNN	O75496	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	GMNN	O75496	SAPCD2	Homo sapiens	Q86UD0	Validated Y2H	32296183
Intra	GMNN	O75496	MCIDAS	Homo sapiens	D6RGH6	Anti Bait CoIP	21543332
Intra	GMNN	O75496	MCIDAS	Homo sapiens	D6RGH6	Anti Tag CoIP	33961781
Intra	GMNN	O75496	MCIDAS	Homo sapiens	D6RGH6	IF	21543332
Intra	GMNN	O75496	MCIDAS	Homo sapiens	D6RGH6	Anti Tag CoIP	28514442
Intra	GMNN	O75496	MCIDAS	Homo sapiens	D6RGH6	Anti Tag CoIP	21543332
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	CoIP	11125146
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Anti Tag CoIP	17318181
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Pull Down	14993212
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	FRET	17318181
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Anti Tag CoIP	26496610
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Validated Y2H	27107012
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	SPR	21543332
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Anti Tag CoIP	33961781
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Anti Tag CoIP	28514442
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Protein Array	15232106
Intra	GMNN	O75496	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	GMNN	O75496	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	GMNN	O75496	ZNF439	Homo sapiens	Q8NDP4	Y2H Prey Pooling	25416956
Intra	GMNN	O75496	ZNF439	Homo sapiens	Q8NDP4	Validated Y2H	32296183
Intra	GMNN	O75496	ZNF439	Homo sapiens	Q8NDP4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Meier-Gorlin Syndrome 6

MGORS6

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Genitourinary Tract Anomalies

Oligodendroglioma

Oligodendroglial Neoplasm	Oligodendroglial Tumor
Oligodendroglial Tumors	Well Differentiated Oligodendroglioma

Meier-Gorlin Syndrome 7

MGORS7

Meier-Gorlin Syndrome, Type 7

Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5

Melanoacanthoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05523	GMNN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GMNN	VGNC	VGNC:41291
Bos taurus	GMNN	VGNC	VGNC:29439
Rattus norvegicus	GMNN	RGD	RGD:1308137
Mus musculus	GMNN	MGD	MGI:1927344
Felis catus	GMNN	VGNC	VGNC:62609
Macaca mulatta	GMNN	VGNC	VGNC:72954
Others	GMNN	NCBI

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