2. Gene
  3. Gak - cyclin G associated kinase Gene

Gak - cyclin G associated kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81659 | Gene type: protein coding

About Gak

Primary_assembly 14: 1,089,866-1,216,398 forward strand.mRatBN7.2:CM026987.1

This gene has 4 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 26.3), Thymus (RPKM 193.3) and 9 other tissues.

Summary

Enables cyclin binding activity. Predicted to be involved in several processes, including Golgi to lysosome transport; clathrin coat disassembly; and clathrin-coated pit assembly. Predicted to act upstream of or within several processes, including Golgi organization; animal organ development; and positive regulation of neural precursor cell proliferation. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Orthologous to human GAK (cyclin G associated kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gak Products(1)

mRNA Protein Name
NM_031030.2 NP_112292.1 cyclin-G-associated kinase
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables cyclin binding IDA
IDA: Inferred from direct assay
9013862 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gak Protein Structure

STKc_GAK

STKc_GAK: cd14036 (38 - 319)

PTP_GAK

PTP_GAK: cd14564 (397 - 559)

PTEN_C2

PTEN_C2: pfam10409 (567 - 705)

PHA03307

PHA03307: cl33723 (818 - 1137)

DnaJ

DnaJ: cd06257 (1252 - 1297)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1305 a.a.
Protein Preferred Names Protein Names

cyclin-G-associated kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-117626 LP-935509 Inhibitor 99.74% Unkown
HY-122186 SGC-GAK-1 99.92% Unkown
HY-120179 LP-922761 98.21% Unkown
HY-15800A CZC-25146 Inhibitor 99.10% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-148063 DB0614 98.80% Unkown
HY-101290A BMT-090605 hydrochloride Inhibitor 99.09% Unkown
HY-124793 GAK inhibitor 49 98.79% Unkown
HY-148061 DB1113 99.28% Unkown
HY-124793A GAK inhibitor 49 hydrochloride 99.52% Unkown
HY-147761 GAK inhibitor 2 Inhibitor / Unkown
HY-120179A LP-922761 hydrate ≥98.0% Unkown
HY-135871 BMT-124110 / Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-101290 BMT-090605 Inhibitor / Unkown
HY-150782 UNC-CA359 Inhibitor / Unkown
HY-159174 EPHA2/A4/GAK-IN-1 Inhibitor / Unkown
HY-P4443 Ac-GAK-AMC / Unkown
HY-RS05235 GAK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05236 Gak Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05237 Gak Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gak NCBI NCBI:2580
Macaca fascicularis Gak NCBI NCBI:102115623
Mus musculus Gak NCBI NCBI:231580