SFXN3 - sideroflexin 3 Gene

Homo sapiens

Also known as SFX3; SLC56A3; BA108L7.2

Gene ID: 81855 | Gene type: protein coding

About SFXN3

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:101,031,234-101,041,241 (from NCBI)

This gene has 8 transcripts (splice variants), 222 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 25.7), duodenum (RPKM 19.3) and 23 other tissues.

Summary

Enables serine transmembrane transporter activity. Involved in serine import into mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SFXN3 Products(10)

mRNA	Protein	Name
NM_001388027.1	NP_001374956.1	sideroflexin-3 isoform 2
NM_001388028.1	NP_001374957.1	sideroflexin-3 isoform 2
NM_001388029.1	NP_001374958.1	sideroflexin-3 isoform 6
NM_001388030.1	NP_001374959.1	sideroflexin-3 isoform 6
NM_001388031.1	NP_001374960.1	sideroflexin-3 isoform 6
NM_001388032.1	NP_001374961.1	sideroflexin-3 isoform 3
NM_001388033.1	NP_001374962.1	sideroflexin-3 isoform 4
NM_001388034.1	NP_001374963.1	sideroflexin-3 isoform 5
NM_001388035.1	NP_001374964.1	sideroflexin-3 isoform 5
NM_030971.6	NP_112233.3	sideroflexin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-serine transmembrane transporter activity	IDA IDA: Inferred from direct assay	30442778	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial transmembrane transport	IDA IDA: Inferred from direct assay	30442778	GOA
acts upstream of one-carbon metabolic process	IDA IDA: Inferred from direct assay	30442778	GOA
involved in serine import into mitochondrion	IDA IDA: Inferred from direct assay	30442778	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	30442778	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFXN3 Protein Structure

Mtc

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

sideroflexin-3

SFXN3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SFXN3	Q9BWM7	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	SFXN3	Q9BWM7	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	SFXN3	Q9BWM7	LAMP2	Homo sapiens	P13473-2	Anti Tag CoIP	28514442
Intra	SFXN3	Q9BWM7	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	SFXN3	Q9BWM7	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	SFXN3	Q9BWM7	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	SFXN3	Q9BWM7	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	SFXN3	Q9BWM7	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	SFXN3	Q9BWM7	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	SFXN3	Q9BWM7	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	SFXN3	Q9BWM7	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	TMEM51	Homo sapiens	Q9NW97	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	LEPROTL1	Homo sapiens	O95214	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	RUSF1	Homo sapiens	Q96GQ5	Y2H Array	32296183
Intra	SFXN3	Q9BWM7	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	RUSF1	Homo sapiens	Q96GQ5	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	SFXN3	Q9BWM7	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	SFXN3	Q9BWM7	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10	Cardiomyopathy And Cataract
Cataract And Cardiomyopathy	MTDPS10
Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome	Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10
Senger Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12787	SFXN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SFXN3	MGD	MGI:2137679
Canis familiaris	SFXN3	VGNC	VGNC:46089
Felis catus	SFXN3	VGNC	VGNC:65071
Rattus norvegicus	SFXN3	RGD	RGD:620716
Bos taurus	SFXN3	VGNC	VGNC:34532
Macaca mulatta	SFXN3	VGNC	VGNC:77245

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