2. Gene
  3. IER3 - immediate early response 3 Gene

IER3 - immediate early response 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DIF2; IEX1; PRG1; DIF-2; GLY96; IEX-1; IEX-1L

Gene ID: 8870 | Gene type: protein coding

About IER3

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,743,199-30,744,547 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele and 124 orthologues. Ubiquitous expression in bone marrow (RPKM 75.0), urinary bladder (RPKM 74.3) and 25 other tissues.

Summary

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced Apoptosis. Partially degraded and unspliced transcripts are found after virus Infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

IER3 Products(1)

mRNA Protein Name
NM_003897.4 NP_003888.2 radiation-inducible immediate-early gene IEX-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15451437 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
20467439 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
20467439 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

radiation-inducible immediate-early gene IEX-1

PACAP-responsive gene 1 protein

IER3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra IER3 P46695 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra IER3 P46695 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra IER3 P46695 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra IER3 P46695 TMBIM6 Homo sapiens P55061
Validated Y2H
32296183
Intra IER3 P46695 PPP2R5C Homo sapiens Q13362
Anti Tag CoIP
16456541
Intra IER3 P46695 SLC13A4 Homo sapiens Q9UKG4
Validated Y2H
32296183
Intra IER3 P46695 SLC13A4 Homo sapiens Q9UKG4
Y2H Prey Pooling
32296183
Intra IER3 P46695 SLC13A4 Homo sapiens Q9UKG4
Y2H Array
32296183
Intra IER3 P46695 PPP2R5B Homo sapiens Q15173
Anti Tag CoIP
16456541
Intra IER3 P46695 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra IER3 P46695 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra IER3 P46695 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra IER3 P46695 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra IER3 P46695 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra IER3 P46695 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra IER3 P46695 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra IER3 P46695 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra IER3 P46695 RELA Homo sapiens Q04206
Anti Tag CoIP
18191642
Intra IER3 P46695 RELA Homo sapiens Q04206
Pull Down
18191642
Intra IER3 P46695 RELA Homo sapiens Q04206
Anti Bait CoIP
18191642
Intra IER3 P46695 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra IER3 P46695 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6

CDCBM6

Cdcbm56

Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6
Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas
Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette
Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1

ARMD1

Senile Macular Degeneration

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy

Amd

Armd

Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Dyslexia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06548 IER3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06549 IER3IP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris IER3 VGNC VGNC:57224
Bos taurus IER3 VGNC VGNC:30039
Felis catus IER3 VGNC VGNC:67695
Macaca mulatta IER3 VGNC VGNC:73560
Mus musculus IER3 MGD MGI:104814
Rattus norvegicus IER3 RGD RGD:1303321