2. Gene
  3. EMC6 - ER membrane protein complex subunit 6 Gene

EMC6 - ER membrane protein complex subunit 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TMEM93; RAB5IFL

Gene ID: 83460 | Gene type: protein coding

About EMC6

This gene has 2 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in kidney (RPKM 12.0), testis (RPKM 10.6) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in autophagosome assembly; protein insertion into ER membrane by stop-transfer membrane-anchor sequence; and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane and integral component of omegasome membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

EMC6 Products(2)

mRNA Protein Name
NM_001014764.3 NP_001014764.1 ER membrane protein complex subunit 6
NM_031298.4 NP_112588.1 ER membrane protein complex subunit 6
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to membrane insertase activity IMP
IMP: Inferred from mutant phenotype
29809151 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22119785 GOA
Biological Process GO Annotation Evidence Reference Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
23182941 GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IDA
IDA: Inferred from direct assay
29242231 GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IMP
IMP: Inferred from mutant phenotype
29809151 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
29242231 GOA
involved in tail-anchored membrane protein insertion into ER membrane IMP
IMP: Inferred from mutant phenotype
29242231 GOA
Cellular Component GO Annotation Evidence Reference Source
part of EMC complex IDA
IDA: Inferred from direct assay
22119785 GOA
part of EMC complex IPI
IPI: Inferred from physical interaction
32439656 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
23182941 GOA
located in membrane IDA
IDA: Inferred from direct assay
22119785 GOA
located in omegasome membrane IDA
IDA: Inferred from direct assay
23182941 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMC6 Protein Structure

Rab5ip

Rab5ip: Rab5-interacting protein (Rab5ip) (25 - 104)

  • 0
  • 100
  • 110 a.a.
Protein Preferred Names Protein Names

ER membrane protein complex subunit 6

transmembrane protein 93

EMC6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
EMC6 Q9BV81 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
EMC6 Q9BV81 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
EMC6 Q9BV81 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra
EMC6 Q9BV81 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
EMC6 Q9BV81 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
EMC6 Q9BV81 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
EMC6 Q9BV81 AQP9 Homo sapiens O43315
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 AQP9 Homo sapiens O43315
Y2H Array
32296183
Intra
EMC6 Q9BV81 MMD Homo sapiens Q15546
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 MMD Homo sapiens Q15546
Y2H Array
32296183
Intra
EMC6 Q9BV81 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
EMC6 Q9BV81 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
EMC6 Q9BV81 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
EMC6 Q9BV81 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
EMC6 Q9BV81 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
EMC6 Q9BV81 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
EMC6 Q9BV81 MMGT1 Homo sapiens Q8N4V1
Anti Tag CoIP
32439656
Intra
EMC6 Q9BV81 MMGT1 Homo sapiens Q8N4V1
Anti Tag CoIP
33961781
Intra
EMC6 Q9BV81 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
EMC6 Q9BV81 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
EMC6 Q9BV81 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
EMC6 Q9BV81 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
EMC6 Q9BV81 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
EMC6 Q9BV81 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
EMC6 Q9BV81 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04340 EMC6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EMC6 VGNC VGNC:28466
Rattus norvegicus EMC6 RGD RGD:1309231
Canis familiaris EMC6 VGNC VGNC:40335
Macaca mulatta EMC6 VGNC VGNC:72130
Mus musculus EMC6 MGD MGI:1913298
Felis catus EMC6 VGNC VGNC:61836