PCGF6 - polycomb group ring finger 6 Gene

Homo sapiens

Also known as MBLR; RNF134

Gene ID: 84108 | Gene type: protein coding

About PCGF6

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,302,796-103,351,140 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 6.3), fat (RPKM 4.5) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PCGF6 Products(2)

mRNA	Protein	Name
NM_001011663.2	NP_001011663.1	polycomb group RING finger protein 6 isoform a
NM_032154.4	NP_115530.2	polycomb group RING finger protein 6 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21282530	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	26151332	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8521824	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	19636380	GOA
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21282530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCGF6 Protein Structure

zf-C3HC4

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

polycomb group RING finger protein 6

Mel18 and Bmi1-like RING finger protein

PCGF6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PCGF6	Q9BYE7	CBX7	Homo sapiens	O95931	Pull Down	21282530
Intra	PCGF6	Q9BYE7	CBX8	Homo sapiens	Q9HC52	Anti Tag CoIP	33961781
Intra	PCGF6	Q9BYE7	CBX8	Homo sapiens	Q9HC52	Anti Tag CoIP	28514442
Intra	PCGF6	Q9BYE7	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	33961781
Intra	PCGF6	Q9BYE7	RNF2	Homo sapiens	Q99496	Y2H Array	22493164
Intra	PCGF6	Q9BYE7	RNF2	Homo sapiens	Q99496	TAP	27705803
Intra	PCGF6	Q9BYE7	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	28514442
Intra	PCGF6	Q9BYE7	RING1	Homo sapiens	Q06587	Anti Tag CoIP	33961781
Intra	PCGF6	Q9BYE7	RING1	Homo sapiens	Q06587	Y2H Array	22493164
Intra	PCGF6	Q9BYE7	RING1	Homo sapiens	Q06587	TAP	27705803

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Medulloblastoma Non-Wnt/Non-Shh

Medulloblastoma Shh Activated And Tp53 Wild-Type

Medulloblastoma Shh-Activated Tp53-Wildtype

Medulloblastoma Wnt Activated

Medulloblastoma Shh Activated

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10149	PCGF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCGF6	RGD	RGD:1306904
Bos taurus	PCGF6	VGNC	VGNC:97296
Mus musculus	PCGF6	MGD	MGI:1918291
Canis familiaris	PCGF6	VGNC	VGNC:44304
Macaca mulatta	PCGF6	VGNC	VGNC:75662
Felis catus	PCGF6	VGNC	VGNC:64068

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