CBX7 - chromobox 7 Gene

Homo sapiens

Gene ID: 23492 | Gene type: protein coding

About CBX7

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,130,772-39,152,680 (from NCBI)

This gene has 7 transcripts (splice variants), 269 orthologues and 8 paralogues. Ubiquitous expression in ovary (RPKM 27.3), endometrium (RPKM 25.8) and 25 other tissues.

Summary

This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]

CBX7 Products(3)

mRNA	Protein	Name
NM_001346743.2	NP_001333672.1	chromobox protein homolog 7 isoform 2
NM_001346744.2	NP_001333673.1	chromobox protein homolog 7 isoform 3
NM_175709.5	NP_783640.1	chromobox protein homolog 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10369680	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19636380	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in chromatin	IDA IDA: Inferred from direct assay	19636380	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21282530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBX7 Protein Structure

Chromo

0
100
200
251 a.a.

Protein Preferred Names

Protein Names

chromobox protein homolog 7

CBX7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CBX7	O95931	PCGF6	Homo sapiens	Q9BYE7	Anti Tag CoIP	28514442
Intra	CBX7	O95931	PCGF6	Homo sapiens	Q9BYE7	TAP	21282530
Intra	CBX7	O95931	PCGF6	Homo sapiens	Q9BYE7	TAP	27705803
Intra	CBX7	O95931	PCGF6	Homo sapiens	Q9BYE7	Anti Tag CoIP	33961781
Intra	CBX7	O95931	MOV10	Homo sapiens	Q9HCE1	Anti Tag CoIP	33961781
Intra	CBX7	O95931	PCGF2	Homo sapiens	P35227	Anti Tag CoIP	19636380
Intra	CBX7	O95931	PCGF2	Homo sapiens	P35227	TAP	21282530
Intra	CBX7	O95931	PCGF2	Homo sapiens	P35227	TAP	27705803
Intra	CBX7	O95931	PCGF2	Homo sapiens	P35227	Pull Down	21282530
Intra	CBX7	O95931	PCGF3	Homo sapiens	Q3KNV8	Anti Tag CoIP	33961781
Intra	CBX7	O95931	PCGF3	Homo sapiens	Q3KNV8	Anti Tag CoIP	21282530
Intra	CBX7	O95931	BMI1	Homo sapiens	P35226	TAP	21282530
Intra	CBX7	O95931	BMI1	Homo sapiens	P35226	TAP	24981860
Intra	CBX7	O95931	BMI1	Homo sapiens	P35226	TAP	27705803
Intra	CBX7	O95931	BMI1	Homo sapiens	P35226	Anti Tag CoIP	33961781
Intra	CBX7	O95931	BMI1	Homo sapiens	P35226	Anti Tag CoIP	28514442
Intra	CBX7	O95931	BMI1	Homo sapiens	P35226	Anti Tag CoIP	21282530
Intra	CBX7	O95931	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	CBX7	O95931	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	CBX7	O95931	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	CBX7	O95931	RNF2	Homo sapiens	Q99496	TAP	27705803
Intra	CBX7	O95931	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	33961781
Intra	CBX7	O95931	RNF2	Homo sapiens	Q99496	TAP	24981860
Intra	CBX7	O95931	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	28514442
Intra	CBX7	O95931	RNF2	Homo sapiens	Q99496	TAP	21282530
Intra	CBX7	O95931	PCGF1	Homo sapiens	Q9BSM1	Anti Tag CoIP	28514442
Intra	CBX7	O95931	PCGF1	Homo sapiens	Q9BSM1	Anti Tag CoIP	33961781
Intra	CBX7	O95931	RING1	Homo sapiens	Q06587	Pull Down	21282530
Intra	CBX7	O95931	RING1	Homo sapiens	Q06587	TAP	21282530
Intra	CBX7	O95931	RING1	Homo sapiens	Q06587	Anti Tag CoIP	33961781
Intra	CBX7	O95931	RING1	Homo sapiens	Q06587	TAP	27705803

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ovarian Clear Cell Adenocarcinoma

Klippel-Feil Syndrome 4

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100832	UNC3866	Inhibitor	/	Unkown
HY-119344	MS37452	Inhibitor	99.81%	Unkown
HY-126327	UNC4976	Antagonist	/	Unkown
HY-RS02014	CBX7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-126327A	UNC4976 TFA	Antagonist	≥98.0%	Unkown
HY-100832A	UNC3866 TFA	Inhibitor	/	Unkown
HY-125655	UNC-4219 TFA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CBX7	RGD	RGD:735027
Macaca mulatta	CBX7	VGNC	VGNC:70561
Felis catus	CBX7	VGNC	VGNC:60425
Canis familiaris	CBX7	VGNC	VGNC:38768
Bos taurus	CBX7	VGNC	VGNC:26820
Mus musculus	CBX7	MGD	MGI:1196439

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