PCGF5 - polycomb group ring finger 5 Gene

Homo sapiens

Also known as RNF159

Gene ID: 84333 | Gene type: protein coding

About PCGF5

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:91,156,219-91,284,337 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 14.7), adrenal (RPKM 12.4) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; centrosome; and nucleoplasm. Part of PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]

PCGF5 Products(3)

mRNA	Protein	Name
NM_001256549.2	NP_001243478.1	polycomb group RING finger protein 5
NM_001257101.2	NP_001244030.1	polycomb group RING finger protein 5
NM_032373.5	NP_115749.2	polycomb group RING finger protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19273555	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25519132	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21282530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCGF5 Protein Structure

zf-C3HC4

0
100
200
256 a.a.

Protein Preferred Names

Protein Names

polycomb group RING finger protein 5

RING finger protein 159

PCGF5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PCGF5	Q86SE9	BCOR	Homo sapiens	Q6W2J9-4	Y2H Array	25416956
Intra	PCGF5	Q86SE9	BCOR	Homo sapiens	Q6W2J9-4	Y2H Prey Pooling	25416956
Cross	PCGF5	Q86SE9	q2ghu2_ehrcr	Ehrlichia chaffeensis	Q2GHU2	Anti Tag CoIP	19273555
Cross	PCGF5	Q86SE9	q2ghu2_ehrcr	Ehrlichia chaffeensis	Q2GHU2	Confocal	19273555
Intra	PCGF5	Q86SE9	AUTS2	Homo sapiens	Q8WXX7	Anti Tag CoIP	33961781
Intra	PCGF5	Q86SE9	AUTS2	Homo sapiens	Q8WXX7	TAP	27705803
Intra	PCGF5	Q86SE9	AUTS2	Homo sapiens	Q8WXX7	Anti Tag CoIP	28514442
Intra	PCGF5	Q86SE9	AUTS2	Homo sapiens	Q8WXX7	Anti Tag CoIP	25519132
Intra	PCGF5	Q86SE9	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	PCGF5	Q86SE9	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	PCGF5	Q86SE9	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	PCGF5	Q86SE9	CBX8	Homo sapiens	Q9HC52	Pull Down	21282530
Intra	PCGF5	Q86SE9	PHC2	Homo sapiens	Q8IXK0	Validated Y2H	25416956
Intra	PCGF5	Q86SE9	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	33961781
Intra	PCGF5	Q86SE9	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	25519132
Intra	PCGF5	Q86SE9	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	22493164
Intra	PCGF5	Q86SE9	RNF2	Homo sapiens	Q99496	TAP	27705803
Intra	PCGF5	Q86SE9	RNF2	Homo sapiens	Q99496	Y2H Array	22493164
Intra	PCGF5	Q86SE9	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	28514442
Intra	PCGF5	Q86SE9	RING1	Homo sapiens	Q06587	Anti Tag CoIP	22493164
Intra	PCGF5	Q86SE9	RING1	Homo sapiens	Q06587	TAP	27705803
Intra	PCGF5	Q86SE9	RING1	Homo sapiens	Q06587	Anti Tag CoIP	33961781
Intra	PCGF5	Q86SE9	RING1	Homo sapiens	Q06587	Y2H Array	22493164

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bainbridge-Ropers Syndrome

BRPS	Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome
Asxl3-Related Disorder

Ehrlichiosis

Human Ehrlichiosis	He
Hey

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10148	PCGF5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PCGF5	VGNC	VGNC:44303
Macaca mulatta	PCGF5	VGNC	VGNC:106085
Rattus norvegicus	PCGF5	RGD	RGD:1583513
Mus musculus	PCGF5	MGD	MGI:1923505
Bos taurus	PCGF5	VGNC	VGNC:32628

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