CRADD - CASP2 and RIPK1 domain containing adaptor with death domain Gene

Homo sapiens

Also known as MRT34; RAIDD

Gene ID: 8738 | Gene type: protein coding

About CRADD

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:93,677,375-93,894,840 (from NCBI)

This gene has 12 transcripts (splice variants), 189 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 3.8), liver (RPKM 2.6) and 25 other tissues.

Summary

This gene encodes a protein containing a death domain (DD) motif. This protein recruits Caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting Apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

CRADD Products(5)

mRNA	Protein	Name
NM_001320099.2	NP_001307028.1	death domain-containing protein CRADD isoform 1
NM_001320100.2	NP_001307029.1	death domain-containing protein CRADD isoform 2
NM_001320101.3	NP_001307030.1	death domain-containing protein CRADD isoform 3
NM_001330126.1	NP_001317055.1	death domain-containing protein CRADD isoform 4
NM_003805.5	NP_003796.1	death domain-containing protein CRADD isoform 1

CRADD Protein Structure

CARD

Death

0
100
199 a.a.

Protein Preferred Names

Protein Names

death domain-containing protein CRADD

CRADD/LYZ fusion

Recombinant CRADD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70050	CRADD Protein, Human	P78560 (M1-E199)	≥95%

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 34, With Variant Lissencephaly

MRT34	Mental Retardation, Autosomal Recessive 34, With Variant Lissencephaly
Mental Retardation, Autosomal Recessive 34

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Megalencephaly

Macroencephaly

Macrencephaly

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Astereognosia

Somatosensory Agnosia

Tactile Agnosia

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03138	CRADD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRADD	VGNC	VGNC:55887
Macaca mulatta	CRADD	VGNC	VGNC:71482
Rattus norvegicus	CRADD	RGD	RGD:1311010
Mus musculus	CRADD	MGD	MGI:1336168
Canis familiaris	CRADD	VGNC	VGNC:39591
Others	CRADD	NCBI

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