CRADD - CASP2 and RIPK1 domain containing adaptor with death domain Gene

Homo sapiens

Also known as MRT34; RAIDD

Gene ID: 8738 | Gene type: protein coding

About CRADD

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:93,677,375-93,894,840 (from NCBI)

This gene has 12 transcripts (splice variants), 189 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 3.8), liver (RPKM 2.6) and 25 other tissues.

Summary

This gene encodes a protein containing a death domain (DD) motif. This protein recruits Caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting Apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

CRADD Products(5)

mRNA	Protein	Name
NM_001320099.2	NP_001307028.1	death domain-containing protein CRADD isoform 1
NM_001320100.2	NP_001307029.1	death domain-containing protein CRADD isoform 2
NM_001320101.3	NP_001307030.1	death domain-containing protein CRADD isoform 3
NM_001330126.1	NP_001317055.1	death domain-containing protein CRADD isoform 4
NM_003805.5	NP_003796.1	death domain-containing protein CRADD isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables death domain binding	IPI IPI: Inferred from physical interaction	9044836	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	9044836	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8985253	GOA
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	9044836	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP IMP: Inferred from mutant phenotype	21726810	GOA
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	8985253	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	11821383	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of endopeptidase complex	IPI IPI: Inferred from physical interaction	15073321	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRADD Protein Structure

CARD

Death

0
100
199 a.a.

Protein Preferred Names

Protein Names

death domain-containing protein CRADD

CRADD/LYZ fusion

CRADD Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CRADD	P78560	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	CRADD	P78560	BBS5	Homo sapiens	Q8N3I7	Validated Y2H	25416956
Intra	CRADD	P78560	KCTD9	Homo sapiens	Q7L273	Y2H Prey Pooling	25416956
Intra	CRADD	P78560	KCTD9	Homo sapiens	Q7L273	Y2H Array	25416956
Intra	CRADD	P78560	CASP2	Homo sapiens	P42575	Anti Bait CoIP	16652156
Intra	CRADD	P78560	CASP2	Homo sapiens	P42575	GMS	15073321
Intra	CRADD	P78560	CASP2	Homo sapiens	P42575	Y2H Prey Pooling	32296183
Intra	CRADD	P78560	CASP2	Homo sapiens	P42575	Y2H	11156409
Intra	CRADD	P78560	CASP2	Homo sapiens	P42575	Anti Tag CoIP	11156409
Intra	CRADD	P78560	CASP2	Homo sapiens	P42575	Y2H Array	31515488
Intra	CRADD	P78560	CASP2	Homo sapiens	P42575	BFG-2H	27107012
Intra	CRADD	P78560	PIDD1	Homo sapiens	Q9HB75	Anti Tag CoIP	27773430
Intra	CRADD	P78560	PIDD1	Homo sapiens	Q9HB75	Anti Bait CoIP	16652156
Intra	CRADD	P78560	APPL2	Homo sapiens	Q8NEU8	Validated Y2H	25416956
Intra	CRADD	P78560	APPL2	Homo sapiens	Q8NEU8	Y2H Array	31515488
Intra	CRADD	P78560	APPL2	Homo sapiens	Q8NEU8	Y2H Prey Pooling	25416956
Cross	CRADD	P78560	tax	Human T-cell leukemia virus 1	P14079	Y2H Array	22458338
Cross	CRADD	P78560	tax	Human T-cell leukemia virus 1	P14079	Y2H Pooling	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CRADD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70050	CRADD Protein, Human	P78560 (M1-E199)	≥95%

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 34, With Variant Lissencephaly

MRT34	Mental Retardation, Autosomal Recessive 34, With Variant Lissencephaly
Mental Retardation, Autosomal Recessive 34

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Megalencephaly

Macroencephaly

Macrencephaly

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Astereognosia

Somatosensory Agnosia

Tactile Agnosia

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03138	CRADD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRADD	VGNC	VGNC:55887
Macaca mulatta	CRADD	VGNC	VGNC:71482
Rattus norvegicus	CRADD	RGD	RGD:1311010
Mus musculus	CRADD	MGD	MGI:1336168
Canis familiaris	CRADD	VGNC	VGNC:39591
Others	CRADD	NCBI

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