PIAS4 - protein inhibitor of activated STAT 4 Gene

Homo sapiens

Also known as PIASY; Piasg; ZMIZ6; PIAS-gamma

Gene ID: 51588 | Gene type: protein coding

About PIAS4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,007,736-4,039,386 (from NCBI)

This gene has 6 transcripts (splice variants), 222 orthologues and 5 paralogues. Broad expression in testis (RPKM 14.8), spleen (RPKM 3.8) and 25 other tissues.

Summary

Enables SUMO Ligase activity and ubiquitin protein Ligase binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of protein sumoylation; and protein sumoylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PIAS4 Products(1)

mRNA	Protein	Name
NM_015897.4	NP_056981.2	E3 SUMO-protein ligase PIAS4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO ligase activity	IDA IDA: Inferred from direct assay	18579533	GOA
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	11731474	GOA
enables SUMO transferase activity	IMP IMP: Inferred from mutant phenotype	22508508	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11388671	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16816390	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11248056	GOA
involved in negative regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	35013556	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	32832608	GOA
involved in positive regulation of protein sumoylation	IDA IDA: Inferred from direct assay	17696781	GOA
involved in protein sumoylation	IDA IDA: Inferred from direct assay	18579533	GOA
involved in protein sumoylation	IMP IMP: Inferred from mutant phenotype	22508508	GOA
involved in regulation of mRNA stability	IDA IDA: Inferred from direct assay	34048572	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16816390	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11248056	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIAS4 Protein Structure

PINIT

zf-MIZ

0
100
200
300
400
510 a.a.

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase PIAS4

RING-type E3 ubiquitin transferase PIAS4

Related Diseases

Diseases

Alias

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h

Lgmd2h	Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency
Muscular Dystrophy Hutterite Type	Sarcotubular Myopathy
Limb-Girdle Muscular Dystrophy Type 2h

Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10476	PIAS4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PIAS4	VGNC	VGNC:75813
Felis catus	PIAS4	VGNC	VGNC:80653
Rattus norvegicus	PIAS4	RGD	RGD:1308737
Canis familiaris	PIAS4	VGNC	VGNC:44522
Mus musculus	PIAS4	MGD	MGI:2136940
Bos taurus	PIAS4	VGNC	VGNC:32858

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