2. Gene
  3. PIAS4 - protein inhibitor of activated STAT 4 Gene

PIAS4 - protein inhibitor of activated STAT 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PIASY; Piasg; ZMIZ6; PIAS-gamma

Gene ID: 51588 | Gene type: protein coding

About PIAS4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,007,736-4,039,386 (from NCBI)

This gene has 6 transcripts (splice variants), 222 orthologues and 5 paralogues. Broad expression in testis (RPKM 14.8), spleen (RPKM 3.8) and 25 other tissues.

Summary

Enables SUMO Ligase activity and ubiquitin protein Ligase binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of protein sumoylation; and protein sumoylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PIAS4 Products(1)

mRNA Protein Name
NM_015897.4 NP_056981.2 E3 SUMO-protein ligase PIAS4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SUMO ligase activity IDA
IDA: Inferred from direct assay
18579533 GOA
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
11731474 GOA
enables SUMO transferase activity IMP
IMP: Inferred from mutant phenotype
22508508 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11388671 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16816390 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11248056 GOA
involved in negative regulation of protein localization to chromatin IDA
IDA: Inferred from direct assay
35013556 GOA
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
32832608 GOA
involved in positive regulation of protein sumoylation IDA
IDA: Inferred from direct assay
17696781 GOA
involved in protein sumoylation IDA
IDA: Inferred from direct assay
18579533 GOA
involved in protein sumoylation IMP
IMP: Inferred from mutant phenotype
22508508 GOA
involved in regulation of mRNA stability IDA
IDA: Inferred from direct assay
34048572 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16816390 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11248056 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIAS4 Protein Structure

PINIT

PINIT: PINIT domain (128 - 277)

zf-MIZ

zf-MIZ: MIZ/SP-RING zinc finger (322 - 371)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 510 a.a.
Protein Preferred Names Protein Names

E3 SUMO-protein ligase PIAS4

RING-type E3 ubiquitin transferase PIAS4

PIAS4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PIAS4 Q8N2W9 WBP1L Homo sapiens Q9NX94
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 WBP1L Homo sapiens Q9NX94
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 WBP1L Homo sapiens Q9NX94
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 LARP4B Homo sapiens Q92615
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 LARP4B Homo sapiens Q92615
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 LARP4B Homo sapiens Q92615
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 MAGEC3 Homo sapiens Q8TD91-2
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 MAGEC3 Homo sapiens Q8TD91-2
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 MAGEC3 Homo sapiens Q8TD91-2
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 ZBTB34 Homo sapiens Q8NCN2
Validated Y2H
32296183
Intra
PIAS4 Q8N2W9 SPATA24 Homo sapiens Q86W54-2
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 SPATA24 Homo sapiens Q86W54-2
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 SPATA24 Homo sapiens Q86W54-2
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 IFI35 Homo sapiens P80217-2
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 IFI35 Homo sapiens P80217-2
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 IFI35 Homo sapiens P80217-2
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 ZMYM6 Homo sapiens O95789-4
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 ZMYM6 Homo sapiens O95789-4
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 ZMYM6 Homo sapiens O95789-4
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 BOD1 Homo sapiens Q96IK1-2
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 BOD1 Homo sapiens Q96IK1-2
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 BOD1 Homo sapiens Q96IK1-2
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 TOP2B Homo sapiens Q02880
Anti Tag CoIP
33961781
Intra
PIAS4 Q8N2W9 AHCYL1 Homo sapiens O43865
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 AHCYL1 Homo sapiens O43865
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 AHCYL1 Homo sapiens O43865
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 GALNT10 Homo sapiens F2Z2M7
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 GALNT10 Homo sapiens F2Z2M7
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 GALNT10 Homo sapiens F2Z2M7
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 CAMKK1 Homo sapiens Q8N5S9-2
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 CAMKK1 Homo sapiens Q8N5S9-2
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 CAMKK1 Homo sapiens Q8N5S9-2
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 ITGB1BP2 Homo sapiens Q9UKP3-2
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 ITGB1BP2 Homo sapiens Q9UKP3-2
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 ITGB1BP2 Homo sapiens Q9UKP3-2
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 KLF15 Homo sapiens Q9UIH9
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 KLF15 Homo sapiens Q9UIH9
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 KLF15 Homo sapiens Q9UIH9
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 CRLF3 Homo sapiens Q8IUI8
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 CRLF3 Homo sapiens Q8IUI8
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 CRLF3 Homo sapiens Q8IUI8
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 MTNAP1 Homo sapiens Q9BSJ5
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 MTNAP1 Homo sapiens Q9BSJ5
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 MTNAP1 Homo sapiens Q9BSJ5
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 GPSM3 Homo sapiens Q9Y4H4
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 GPSM3 Homo sapiens Q9Y4H4
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 GPSM3 Homo sapiens Q9Y4H4
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 PARP1 Homo sapiens P09874
Pull Down
19779455
Intra
PIAS4 Q8N2W9 PARP1 Homo sapiens P09874
Anti Bait CoIP
19779455
Intra
PIAS4 Q8N2W9 SMARCD1 Homo sapiens Q96GM5
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 SMARCD1 Homo sapiens Q96GM5
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 ESRRA Homo sapiens P11474
Y2H
21988832
Intra
PIAS4 Q8N2W9 FAM117B Homo sapiens Q6P1L5
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 FAM117B Homo sapiens Q6P1L5
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 FAM117B Homo sapiens Q6P1L5
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 NMT2 Homo sapiens O60551
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 NMT2 Homo sapiens O60551
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 NMT2 Homo sapiens O60551
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 HOXC4 Homo sapiens P09017
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 HOXC4 Homo sapiens P09017
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 HOXC4 Homo sapiens P09017
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 ELL2 Homo sapiens O00472
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 ELL2 Homo sapiens O00472
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 ELL2 Homo sapiens O00472
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 HIF1A Homo sapiens Q16665
Anti Tag CoIP
20661221
Intra
PIAS4 Q8N2W9 HTT Homo sapiens P42858
Y2H
15383276
Intra
PIAS4 Q8N2W9 HTT Homo sapiens P42858
Pull Down
15383276
Intra
PIAS4 Q8N2W9 SUMO2 Homo sapiens P61956
Y2H
15383276
Intra
PIAS4 Q8N2W9 TADA3 Homo sapiens O75528
Anti Tag CoIP
33961781
Intra
PIAS4 Q8N2W9 CCDC141 Homo sapiens Q6ZP82-1
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 CCDC141 Homo sapiens Q6ZP82-1
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 CCDC141 Homo sapiens Q6ZP82-1
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 LPIN1 Homo sapiens Q14693
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 LPIN1 Homo sapiens Q14693
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 LPIN1 Homo sapiens Q14693
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 SAP30 Homo sapiens O75446
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 SAP30 Homo sapiens O75446
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 SAP30 Homo sapiens O75446
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 CDH1 Homo sapiens P12830
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 CDH1 Homo sapiens P12830
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 CDH1 Homo sapiens P12830
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 RELA Homo sapiens Q04206
Anti Bait CoIP
17606919
Intra
PIAS4 Q8N2W9 RELA Homo sapiens Q04206
Anti Tag CoIP
17606919
Intra
PIAS4 Q8N2W9 RBM11 Homo sapiens P57052
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 RBM11 Homo sapiens P57052
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 RBM11 Homo sapiens P57052
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 KCTD13 Homo sapiens Q8WZ19
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 KCTD13 Homo sapiens Q8WZ19
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 KCTD13 Homo sapiens Q8WZ19
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 MYOZ1 Homo sapiens Q9NP98
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 MYOZ1 Homo sapiens Q9NP98
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 MYOZ1 Homo sapiens Q9NP98
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 GABPB2 Homo sapiens Q8TAK5
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 GABPB2 Homo sapiens Q8TAK5
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 GABPB2 Homo sapiens Q8TAK5
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 GATA1 Homo sapiens P15976-2
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 GATA1 Homo sapiens P15976-2
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 GATA1 Homo sapiens P15976-2
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 SHOX2 Homo sapiens O60902-3
Y2H Pooling
32814053
Intra
PIAS4 Q8N2W9 SHOX2 Homo sapiens O60902-3
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 SHOX2 Homo sapiens O60902-3
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 BECN1 Homo sapiens Q14457
Y2H Array
32814053
Intra
PIAS4 Q8N2W9 BECN1 Homo sapiens Q14457
Validated Y2H
32814053
Intra
PIAS4 Q8N2W9 BECN1 Homo sapiens Q14457
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h

Lgmd2h

Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency

Muscular Dystrophy Hutterite Type

Sarcotubular Myopathy

Limb-Girdle Muscular Dystrophy Type 2h
Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10476 PIAS4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PIAS4 VGNC VGNC:75813
Felis catus PIAS4 VGNC VGNC:80653
Rattus norvegicus PIAS4 RGD RGD:1308737
Canis familiaris PIAS4 VGNC VGNC:44522
Mus musculus PIAS4 MGD MGI:2136940
Bos taurus PIAS4 VGNC VGNC:32858