1. Gene
  2. TMBIM6 - transmembrane BAX inhibitor motif containing 6 Gene

TMBIM6 - transmembrane BAX inhibitor motif containing 6 Gene

Homo sapiens

Also known as BI-1; TEGT; BAXI1

Gene ID: 7009 | Gene type: protein coding

About TMBIM6

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,741,557-49,764,934 (from NCBI)

This gene has 28 transcripts (splice variants), 251 orthologues and 5 paralogues. Ubiquitous expression in kidney (RPKM 392.9), liver (RPKM 352.7) and 25 other tissues.

Summary

Enables endoribonuclease inhibitor activity and ubiquitin protein Ligase binding activity. Involved in several processes, including negative regulation of RNA metabolic process; negative regulation of intrinsic apoptotic signaling pathway; and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane and mitochondrial membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

TMBIM6 Products(2)

mRNA Protein Name
NM_001098576.2 NP_001092046.1 bax inhibitor 1 isoform 2
NM_003217.3 NP_003208.2 bax inhibitor 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables endoribonuclease inhibitor activity IDA
IDA: Inferred from direct assay
19328063 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
19328063 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9660918 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
21068390 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9660918 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19328063 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
9660918 GOA
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
9660918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMBIM6 Protein Structure

Bax1-I

Bax1-I: Inhibitor of apoptosis-promoting Bax1 (24 - 225)

  • 0
  • 100
  • 200
  • 237 a.a.
Protein Preferred Names Protein Names

bax inhibitor 1

testis enhanced gene transcript

TMBIM6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TMBIM6 P55061 CD300LG Homo sapiens Q6UXG3 32296183
Intra
TMBIM6 P55061 CD300LG Homo sapiens Q6UXG3 32296183
Intra
TMBIM6 P55061 CD300LG Homo sapiens Q6UXG3 32296183
Intra
TMBIM6 P55061 JSRP1 Homo sapiens Q96MG2 32296183
Intra
TMBIM6 P55061 JSRP1 Homo sapiens Q96MG2 32296183
Intra
TMBIM6 P55061 JSRP1 Homo sapiens Q96MG2 32296183
Intra
TMBIM6 P55061 REEP2 Homo sapiens Q9BRK0 32296183
Intra
TMBIM6 P55061 REEP2 Homo sapiens Q9BRK0 32296183
Intra
TMBIM6 P55061 REEP2 Homo sapiens Q9BRK0 32296183
Intra
TMBIM6 P55061 TMUB1 Homo sapiens Q9BVT8 32296183
Intra
TMBIM6 P55061 TMUB1 Homo sapiens Q9BVT8 32296183
Intra
TMBIM6 P55061 TMUB1 Homo sapiens Q9BVT8 32296183
Intra
TMBIM6 P55061 GPHB5 Homo sapiens Q86YW7 32296183
Intra
TMBIM6 P55061 GPHB5 Homo sapiens Q86YW7 32296183
Intra
TMBIM6 P55061 GPHB5 Homo sapiens Q86YW7 32296183
Intra
TMBIM6 P55061 GPX8 Homo sapiens Q8TED1 32296183
Intra
TMBIM6 P55061 GPX8 Homo sapiens Q8TED1 32296183
Intra
TMBIM6 P55061 GPX8 Homo sapiens Q8TED1 32296183
Intra
TMBIM6 P55061 GPR151 Homo sapiens Q8TDV0 32296183
Intra
TMBIM6 P55061 GPR151 Homo sapiens Q8TDV0 32296183
Intra
TMBIM6 P55061 GPR151 Homo sapiens Q8TDV0 32296183
Intra
TMBIM6 P55061 ATP13A1 Homo sapiens Q9HD20-3 32296183
Intra
TMBIM6 P55061 ATP13A1 Homo sapiens Q9HD20-3 32296183
Intra
TMBIM6 P55061 ATP13A1 Homo sapiens Q9HD20-3 32296183
Intra
TMBIM6 P55061 FXYD3 Homo sapiens Q14802-3 32296183
Intra
TMBIM6 P55061 FXYD3 Homo sapiens Q14802-3 32296183
Intra
TMBIM6 P55061 FXYD3 Homo sapiens Q14802-3 32296183
Intra
TMBIM6 P55061 PIANP Homo sapiens Q8IYJ0 32296183
Intra
TMBIM6 P55061 PIANP Homo sapiens Q8IYJ0 32296183
Intra
TMBIM6 P55061 PIANP Homo sapiens Q8IYJ0 32296183
Intra
TMBIM6 P55061 KCNA10 Homo sapiens Q16322 32296183
Intra
TMBIM6 P55061 KCNA10 Homo sapiens Q16322 32296183
Intra
TMBIM6 P55061 KCNA10 Homo sapiens Q16322 32296183
Intra
TMBIM6 P55061 ODF4 Homo sapiens Q2M2E3 32296183
Intra
TMBIM6 P55061 ODF4 Homo sapiens Q2M2E3 32296183
Intra
TMBIM6 P55061 ODF4 Homo sapiens Q2M2E3 32296183
Intra
TMBIM6 P55061 MS4A3 Homo sapiens Q96HJ5 32296183
Intra
TMBIM6 P55061 MS4A3 Homo sapiens Q96HJ5 32296183
Intra
TMBIM6 P55061 MS4A3 Homo sapiens Q96HJ5 32296183
Intra
TMBIM6 P55061 OPRM1 Homo sapiens P35372-10 32296183
Intra
TMBIM6 P55061 OPRM1 Homo sapiens P35372-10 32296183
Intra
TMBIM6 P55061 PI16 Homo sapiens Q6UXB8 32296183
Intra
TMBIM6 P55061 PI16 Homo sapiens Q6UXB8 32296183
Intra
TMBIM6 P55061 PI16 Homo sapiens Q6UXB8 32296183
Intra
TMBIM6 P55061 HJV Homo sapiens Q6ZVN8-3 32296183
Intra
TMBIM6 P55061 HJV Homo sapiens Q6ZVN8-3 32296183
Intra
TMBIM6 P55061 HJV Homo sapiens Q6ZVN8-3 32296183
Intra
TMBIM6 P55061 KCNC1 Homo sapiens P48547 32296183
Intra
TMBIM6 P55061 KCNC1 Homo sapiens P48547 32296183
Intra
TMBIM6 P55061 GJB4 Homo sapiens Q9NTQ9 32296183
Intra
TMBIM6 P55061 GJB4 Homo sapiens Q9NTQ9 32296183
Intra
TMBIM6 P55061 GJB4 Homo sapiens Q9NTQ9 32296183
Intra
TMBIM6 P55061 SLC12A7 Homo sapiens Q9Y666-2 32296183
Intra
TMBIM6 P55061 SLC12A7 Homo sapiens Q9Y666-2 32296183
Intra
TMBIM6 P55061 SLC12A7 Homo sapiens Q9Y666-2 32296183
Intra
TMBIM6 P55061 UGT2B11 Homo sapiens O75310 32296183
Intra
TMBIM6 P55061 UGT2B11 Homo sapiens O75310 32296183
Intra
TMBIM6 P55061 RHBDL2 Homo sapiens Q9NX52-3 32296183
Intra
TMBIM6 P55061 RHBDL2 Homo sapiens Q9NX52-3 32296183
Intra
TMBIM6 P55061 RHBDL2 Homo sapiens Q9NX52-3 32296183
Intra
TMBIM6 P55061 FGFBP2 Homo sapiens Q9BYJ0 32296183
Intra
TMBIM6 P55061 FGFBP2 Homo sapiens Q9BYJ0 32296183
Intra
TMBIM6 P55061 FGFBP2 Homo sapiens Q9BYJ0 32296183
Intra
TMBIM6 P55061 STEAP1B Homo sapiens Q6NZ63 32296183
Intra
TMBIM6 P55061 STEAP1B Homo sapiens Q6NZ63 32296183
Intra
TMBIM6 P55061 STEAP1B Homo sapiens Q6NZ63 32296183
Intra
TMBIM6 P55061 SLAMF6 Homo sapiens Q96DU3 32296183
Intra
TMBIM6 P55061 SLAMF6 Homo sapiens Q96DU3 32296183
Intra
TMBIM6 P55061 SLAMF6 Homo sapiens Q96DU3 32296183
Intra
TMBIM6 P55061 TREML1 Homo sapiens Q86YW5 32296183
Intra
TMBIM6 P55061 TREML1 Homo sapiens Q86YW5 32296183
Intra
TMBIM6 P55061 TREML1 Homo sapiens Q86YW5 32296183
Intra
TMBIM6 P55061 SCN3B Homo sapiens Q9NY72 32296183
Intra
TMBIM6 P55061 SCN3B Homo sapiens Q9NY72 32296183
Intra
TMBIM6 P55061 SCN3B Homo sapiens Q9NY72 32296183
Intra
TMBIM6 P55061 ENPP4 Homo sapiens Q9Y6X5 32296183
Intra
TMBIM6 P55061 ENPP4 Homo sapiens Q9Y6X5 32296183
Intra
TMBIM6 P55061 ENPP4 Homo sapiens Q9Y6X5 32296183
Intra
TMBIM6 P55061 GJA8 Homo sapiens P48165 32296183
Intra
TMBIM6 P55061 GJA8 Homo sapiens P48165 32296183
Intra
TMBIM6 P55061 IER3 Homo sapiens P46695 32296183
Intra
TMBIM6 P55061 IER3 Homo sapiens P46695 32296183
Intra
TMBIM6 P55061 ADIPOR2 Homo sapiens Q86V24 32296183
Intra
TMBIM6 P55061 ADIPOR2 Homo sapiens Q86V24 32296183
Intra
TMBIM6 P55061 ADIPOR2 Homo sapiens Q86V24 32296183
Intra
TMBIM6 P55061 CLDN22 Homo sapiens Q8N7P3 32296183
Intra
TMBIM6 P55061 CLDN22 Homo sapiens Q8N7P3 32296183
Intra
TMBIM6 P55061 CLDN22 Homo sapiens Q8N7P3 32296183
Intra
TMBIM6 P55061 GPR42 Homo sapiens O15529 32296183
Intra
TMBIM6 P55061 GPR42 Homo sapiens O15529 32296183
Intra
TMBIM6 P55061 FAM209A Homo sapiens Q5JX71 32296183
Intra
TMBIM6 P55061 FAM209A Homo sapiens Q5JX71 32296183
Intra
TMBIM6 P55061 FAM209A Homo sapiens Q5JX71 32296183
Intra
TMBIM6 P55061 TEX29 Homo sapiens Q8N6K0 32296183
Intra
TMBIM6 P55061 TEX29 Homo sapiens Q8N6K0 32296183
Intra
TMBIM6 P55061 TEX29 Homo sapiens Q8N6K0 32296183
Intra
TMBIM6 P55061 SYT9 Homo sapiens Q86SS6 32296183
Intra
TMBIM6 P55061 SYT9 Homo sapiens Q86SS6 32296183
Intra
TMBIM6 P55061 SYT9 Homo sapiens Q86SS6 32296183
Intra
TMBIM6 P55061 COBLL1 Homo sapiens A0A7P0TAB9 32296183
Intra
TMBIM6 P55061 RNF185 Homo sapiens Q96GF1 32296183
Intra
TMBIM6 P55061 RNF185 Homo sapiens Q96GF1 32296183
Intra
TMBIM6 P55061 RNF185 Homo sapiens Q96GF1 32296183
Intra
TMBIM6 P55061 CD99L2 Homo sapiens Q8TCZ2 32296183
Intra
TMBIM6 P55061 CD99L2 Homo sapiens Q8TCZ2 32296183
Intra
TMBIM6 P55061 CD99L2 Homo sapiens Q8TCZ2 32296183
Intra
TMBIM6 P55061 LIME1 Homo sapiens Q9H400 32296183
Intra
TMBIM6 P55061 LIME1 Homo sapiens Q9H400 32296183
Intra
TMBIM6 P55061 LIME1 Homo sapiens Q9H400 32296183
Intra
TMBIM6 P55061 HERPUD2 Homo sapiens Q9BSE4 32296183
Intra
TMBIM6 P55061 HERPUD2 Homo sapiens Q9BSE4 32296183
Intra
TMBIM6 P55061 HERPUD2 Homo sapiens Q9BSE4 32296183
Intra
TMBIM6 P55061 LRRC59 Homo sapiens Q96AG4 32296183
Intra
TMBIM6 P55061 LRRC59 Homo sapiens Q96AG4 32296183
Intra
TMBIM6 P55061 LRRC59 Homo sapiens Q96AG4 32296183
Intra
TMBIM6 P55061 MFSD14B Homo sapiens Q5SR56 32296183
Intra
TMBIM6 P55061 MFSD14B Homo sapiens Q5SR56 32296183
Intra
TMBIM6 P55061 MFSD14B Homo sapiens Q5SR56 32296183
Intra
TMBIM6 P55061 CDC7 Homo sapiens O00311 32296183
Intra
TMBIM6 P55061 CDC7 Homo sapiens O00311 32296183
Intra
TMBIM6 P55061 MANBAL Homo sapiens Q9NQG1 32296183
Intra
TMBIM6 P55061 MANBAL Homo sapiens Q9NQG1 32296183
Intra
TMBIM6 P55061 MANBAL Homo sapiens Q9NQG1 32296183
Intra
TMBIM6 P55061 GZMK Homo sapiens P49863 32296183
Intra
TMBIM6 P55061 GZMK Homo sapiens P49863 32296183
Intra
TMBIM6 P55061 EBP Homo sapiens Q15125 32296183
Intra
TMBIM6 P55061 EBP Homo sapiens Q15125 32296183
Intra
TMBIM6 P55061 EBP Homo sapiens Q15125 32296183
Intra
TMBIM6 P55061 PVR Homo sapiens P15151 32296183
Intra
TMBIM6 P55061 PVR Homo sapiens P15151 32296183
Intra
TMBIM6 P55061 SLC7A1 Homo sapiens P30825 32296183
Intra
TMBIM6 P55061 SLC7A1 Homo sapiens P30825 32296183
Intra
TMBIM6 P55061 ESAM Homo sapiens Q96AP7 32296183
Intra
TMBIM6 P55061 ESAM Homo sapiens Q96AP7 32296183
Intra
TMBIM6 P55061 ESAM Homo sapiens Q96AP7 32296183
Intra
TMBIM6 P55061 TNFRSF17 Homo sapiens Q02223 32296183
Intra
TMBIM6 P55061 TNFRSF17 Homo sapiens Q02223 32296183
Intra
TMBIM6 P55061 TNFRSF17 Homo sapiens Q02223 32296183
Intra
TMBIM6 P55061 MMGT1 Homo sapiens Q8N4V1 32296183
Intra
TMBIM6 P55061 MMGT1 Homo sapiens Q8N4V1 32296183
Intra
TMBIM6 P55061 MMGT1 Homo sapiens Q8N4V1 32296183
Intra
TMBIM6 P55061 TMX2 Homo sapiens Q9Y320 32296183
Intra
TMBIM6 P55061 TMX2 Homo sapiens Q9Y320 32296183
Intra
TMBIM6 P55061 TMX2 Homo sapiens Q9Y320 32296183
Intra
TMBIM6 P55061 CREB3L1 Homo sapiens Q96BA8 32296183
Intra
TMBIM6 P55061 CREB3L1 Homo sapiens Q96BA8 32296183
Intra
TMBIM6 P55061 CREB3L1 Homo sapiens Q96BA8 32296183
Intra
TMBIM6 P55061 SIT1 Homo sapiens Q9Y3P8 32296183
Intra
TMBIM6 P55061 SIT1 Homo sapiens Q9Y3P8 32296183
Intra
TMBIM6 P55061 SIT1 Homo sapiens Q9Y3P8 32296183
Intra
TMBIM6 P55061 GYPA Homo sapiens P02724 32296183
Intra
TMBIM6 P55061 GYPA Homo sapiens P02724 32296183
Intra
TMBIM6 P55061 SLC41A3 Homo sapiens Q96GZ6 32296183
Intra
TMBIM6 P55061 SLC41A3 Homo sapiens Q96GZ6 32296183
Intra
TMBIM6 P55061 SLC41A3 Homo sapiens Q96GZ6 32296183
Intra
TMBIM6 P55061 GJA5 Homo sapiens P36382 32296183
Intra
TMBIM6 P55061 GJA5 Homo sapiens P36382 32296183
Intra
TMBIM6 P55061 CD79A Homo sapiens P11912 32296183
Intra
TMBIM6 P55061 CD79A Homo sapiens P11912 32296183
Intra
TMBIM6 P55061 SOAT2 Homo sapiens O75908 32296183
Intra
TMBIM6 P55061 SOAT2 Homo sapiens O75908 32296183
Intra
TMBIM6 P55061 ERP29 Homo sapiens P30040 32296183
Intra
TMBIM6 P55061 ERP29 Homo sapiens P30040 32296183
Intra
TMBIM6 P55061 HTR2C Homo sapiens P28335 32296183
Intra
TMBIM6 P55061 HTR2C Homo sapiens P28335 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chronic Congestive Splenomegaly
Hypoglycemia, Leucine-Induced

Leucine-Sensitive Hypoglycemia Of Infancy

Leucine-Induced Hypoglycemia

LIH

Hypoglycemia Of Infancy, Leucine-Sensitive

Familial Infantile Hypoglycemia Precipitated By Leucine

Hypoglycemia Leucine Induced

Hypoglycemia Leucine-Induced

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus TMBIM6 VGNC VGNC:66233
Canis familiaris TMBIM6 VGNC VGNC:47419
Macaca mulatta TMBIM6 VGNC VGNC:107118
Bos taurus TMBIM6 VGNC VGNC:35916
Rattus norvegicus TMBIM6 RGD RGD:3842
Mus musculus TMBIM6 MGD MGI:99682