TRPA1 - transient receptor potential cation channel subfamily A member 1 Gene

Homo sapiens

Also known as FEPS; p120; FEPS1; ANKTM1

Gene ID: 8989 | Gene type: protein coding

About TRPA1

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:72,021,250-72,090,010 (from NCBI)

This gene has 6 transcripts (splice variants), 228 orthologues and is associated with 3 phenotypes. Biased expression in urinary bladder (RPKM 5.8), colon (RPKM 2.2) and 5 other tissues.

Summary

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

TRPA1 Products(1)

mRNA	Protein	Name
NM_007332.3	NP_015628.2	transient receptor potential cation channel subfamily A member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25855297	GOA
enables intracellularly gated calcium channel activity	IDA IDA: Inferred from direct assay	20547126	GOA
enables intracellularly gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	25855297	GOA
enables temperature-gated cation channel activity	IDA IDA: Inferred from direct assay	20547126	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	20547126	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	30990108	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	30990108	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	25855297	GOA
involved in response to cold	IMP IMP: Inferred from mutant phenotype	20547126	GOA
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	20547126	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	20547126	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPA1 Protein Structure

Ank_2

Ank

Ank_2

Ion_trans

0
200
400
600
800
1000
1119 a.a.

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily A member 1

ankyrin-like with transmembrane domains 1

Related Diseases

Diseases

Alias

Episodic Pain Syndrome, Familial, 1

FEPS1	Familial Episodic Pain Syndrome With Predominantly Upper Body Involvement
Familial Episodic Pain Syndrome 1

Cramp-Fasciculation Syndrome

Cramp Fasciculation Syndrome

Foley-Denny-Brown Syndrome

Dentin Sensitivity

Sensitive Dentin

Familial Episodic Pain Syndrome

Feps

Photokeratitis

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor	Psychosomatic Disorder
Psychophysiologic Disorders

Lidocaine Allergy

Lidoderm Allergy	Lignocaine Allergy
Xylocaine Allergy

Irritable Bowel Syndrome

Irritable Colon	Psychogenic Ibs
Ibs - [Irritable Bowel Syndrome]	Spastic Bowel Syndrome

Alcoholic Neuropathy

Alcoholic Polyneuropathy	Alcohol-Related Polyneuropathy
Alcohol-Induced Polyneuropathy	Alcoholic Peripheral Neuropathy

Pain Agnosia

Analgesia

Interstitial Cystitis

Bladder Pain Syndrome	Painful Bladder Syndrome
Ulcerative Cystitis	Ic/Bps
Ic/Pbs	Interstitial Cystitis/Bladder Pain Syndrome
Interstitial Cystitis/Painful Bladder Syndrome	Cystitis, Interstitial
Chronic Interstitial Cystitis	Pelvic Congestion Syndrome
Trigonitis

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Complex Regional Pain Syndrome

Complex Regional Pain Syndromes	Reflex Sympathetic Dystrophy
Crps

Trigeminal Nerve Disease

Trigeminal Nerve Diseases	Disorders Of 5th Cranial Nerve
Disorders Of The Fifth Cranial Nerve

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Episodic Pain Syndrome, Familial, 3

FEPS3	Familial Episodic Pain Syndrome With Predominantly Lower Limb Involvement
Familial Episodic Pain Syndrome 3

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Cough Variant Asthma

Episodic Pain Syndrome, Familial, 2

FEPS2

Familial Episodic Pain Syndrome 2

Hyperhidrosis, Gustatory

Frey Syndrome	Gustatory Sweating
Auriculotemporal Nerve Syndrome	Gustatory Hyperhidrosis
Frey'S Syndrome	Sweating, Gustatory
HYPRG	Baillarger Syndrome
Hyperhidrosis Gustatory	Auriculotemporal Syndrome

Viral Laryngitis

Trigeminal Neuralgia

Tic Douloureux	Trifacial Neuralgia
Trifocal Neuralgia	Neuralgia Of The Fifth Cranial Nerve
Neuralgia Of 5th Cranial Nerve	Infraorbital Neuralgia

Detrusor Sphincter Dyssynergia

Detrusor And Sphincter Dyssynergia

Spondyloepiphyseal Dysplasia, Maroteaux Type

Spondyloepiphyseal Dysplasia Maroteaux Type	Pseudo-Morquio Syndrome Type 2
Sed, Maroteaux Type	Brachyolmia Type 2
Pseudo-Morquio Syndrome, Type 2	Spondyloepiphyseal Dysplasia Of Maroteaux
Brachyolmia Maroteaux Type	SEDM
Sed Maroteaux Type	Dysplasia, Spondyloepiphyseal, Maroteaux Type

Paroxysmal Extreme Pain Disorder

PEPD	Familial Rectal Pain
Pexpd	Submandibular, Ocular, And Rectal Pain With Flushing
Pain, Submandibular, Ocular, And Rectal, With Flushing	Rectal Pain, Familial
Submandibular, Ocular And Rectal Pain With Flushing	Familial Rectal Syndrome
Frp	Pain Disorder, Paroxysmal, Extreme

Autonomic Nervous System Disease

Autonomic Nervous System Dysfunction	Autonomic Nervous System Disorders
Autonomic Nervous System Disorder	Autonomic Nervous System Diseases
Abnormality Of The Autonomic Nervous System

Diabetic Neuropathy

Diabetic Neuropathies

Erythromelalgia

Primary Erythromelalgia	Erythermalgia
Primary Erythermalgia	Mitchell Disease
Familial Erythromelalgia

Neurodermatitis

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Lennox-Gastaut Syndrome

Lennox Syndrome	Encephalopathy Of Childhood
Epileptic Encephalopathy Lennox-Gastaut Type	Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves
Lgs

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6810	Thymol		99.97%	Yes
HY-N6810R	Thymol (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-156684	GDC-6599	Inhibitor	99.77%	Phase 2
HY-108463	A-967079	Antagonist	99.30%	Phase 1
HY-115877	GDC-0334	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (45)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100965	Diphenyleneiodonium chloride		99.91%	Unkown
HY-15064	HC-030031	Inhibitor	99.97%	Unkown
HY-101507	Pico145	Inhibitor	99.40%	Unkown
HY-N6825	Hydroxy-α-sanshool	Agonist	99.57%	Unkown
HY-107436	LE135		99.03%	Unkown
HY-111132	JT010	Agonist	99.90%	Unkown
HY-135013	Umbellulone	Activator	99.60%	Unkown
HY-W014421	AP-18	Inhibitor	99.80%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-108329	AM-0902	Antagonist	99.65%	Unkown
HY-18779	PF-4840154	Agonist	98.15%	Unkown
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-120689	PF-04745637	Antagonist	99.97%	Unkown
HY-101907	ASP7663	Agonist	99.16%	Unkown
HY-N1500	Pulegone	Activator	98.80%	Unkown
HY-W002116	Methyl syringate	Activator	99.95%	Unkown
HY-121636	Resolvin D2	Inhibitor	≥99.0%	Unkown
HY-121539	Supercinnamaldehyde	Activator	≥99.0%	Unkown
HY-148236	BAY-390	Inhibitor	98.01%	Unkown
HY-15065	Chembridge-5861528	Antagonist	99.76%	Unkown
HY-N2318	Podocarpic acid	Agonist	99.78%	Unkown
HY-N7117	1,4-Cineole	Activator	≥95.0%	Unkown
HY-107535	AS1269574		99.84%	Unkown
HY-153711	TRPA1-IN-2	Inhibitor	99.82%	Unkown
HY-12809	Optovin	Activator	99.81%	Unkown
HY-P5914A	Wasabi Receptor Toxin TFA	Activator	99.49%	Unkown
HY-134098	Diisopropyl adipate	Activator	99.90%	Unkown
HY-114524	(E)-4-Oxo-2-nonenal	Agonist	/	Unkown
HY-121636S	Resolvin D2-d5	Inhibitor	/	Unkown
HY-N7536	Voacangine		98.78%	Unkown
HY-P5914	Wasabi Receptor Toxin	Activator	/	Unkown
HY-W106234	4-(Phenyldiazenyl)benzoic acid	Agonist	98.81%	Unkown
HY-142214	TRPA1-IN-1	Antagonist	/	Unkown
HY-111494	TRPA1 Antagonist 1	Inhibitor	/	Unkown
HY-104061	AMG8788	Antagonist	/	Unkown
HY-104062	AMG9678	Antagonist	/	Unkown
HY-139904	TRPA1 Antagonist 3	Agonist	/	Unkown
HY-15056	AMG 9090	Agonist	/	Unkown
HY-N12605	hTRPA1-IN-1	Inhibitor	/	Unkown
HY-N7965	Methyl kakuol	Agonist	/	Unkown
HY-RS15103	TRPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W002116S	Methyl syringate-d6		/	Unkown
HY-159134	TRPA1-IN-3	Inhibitor	/	Unkown
HY-N5142S1	α-Terpineol-d6	Inhibitor	/	Unkown
HY-W708469	Resolvin D2 methyl ester	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRPA1	MGD	MGI:3522699
Canis familiaris	TRPA1	VGNC	VGNC:47865
Felis catus	TRPA1	VGNC	VGNC:67587
Macaca mulatta	TRPA1	VGNC	VGNC:78429
Bos taurus	TRPA1	VGNC	VGNC:36380
Rattus norvegicus	TRPA1	RGD	RGD:1303284
Others	TRPA1	NCBI