2. Gene
  3. CLDN9 - claudin 9 Gene

CLDN9 - claudin 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DFNB116

Gene ID: 9080 | Gene type: protein coding

About CLDN9

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,012,923-3,014,505 (from NCBI)

This gene has 1 transcript (splice variant), 86 orthologues, 22 paralogues and is associated with 1 phenotype.

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010]

CLDN9 Products(1)

mRNA Protein Name
NM_020982.4 NP_066192.1 claudin-9
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20375010 GOA
enables virus receptor activity IMP
IMP: Inferred from mutant phenotype
20375010 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20375010 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
31175426 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN9 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (5 - 180)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

claudin-9

CLDN9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CLDN9 O95484 GRM2 Homo sapiens Q14416
Validated Y2H
32296183
Intra
CLDN9 O95484 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
CLDN9 O95484 ADIPOQ Homo sapiens Q15848
Validated Y2H
32296183
Intra
CLDN9 O95484 ERMP1 Homo sapiens Q7Z2K6
Validated Y2H
32296183
Intra
CLDN9 O95484 PLPP6 Homo sapiens Q8IY26
Validated Y2H
32296183
Intra
CLDN9 O95484 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra
CLDN9 O95484 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra
CLDN9 O95484 VSTM1 Homo sapiens Q6UX27-3
Validated Y2H
32296183
Intra
CLDN9 O95484 PLPPR2 Homo sapiens Q96GM1
Y2H Array
32296183
Intra
CLDN9 O95484 PLPPR2 Homo sapiens Q96GM1
Y2H Prey Pooling
32296183
Intra
CLDN9 O95484 PLPPR2 Homo sapiens Q96GM1
Validated Y2H
32296183
Intra
CLDN9 O95484 EXTL1 Homo sapiens Q92935
Validated Y2H
32296183
Intra
CLDN9 O95484 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
Intra
CLDN9 O95484 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
CLDN9 O95484 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
CLDN9 O95484 AOC3 Homo sapiens Q16853
Validated Y2H
32296183
Intra
CLDN9 O95484 MAL Homo sapiens P21145
Validated Y2H
32296183
Intra
CLDN9 O95484 EMP1 Homo sapiens P54849
Validated Y2H
32296183
Intra
CLDN9 O95484 IGFBP5 Homo sapiens P24593
Validated Y2H
32296183
Intra
CLDN9 O95484 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra
CLDN9 O95484 BNIP3 Homo sapiens Q12983
Validated Y2H
32296183
Intra
CLDN9 O95484 MALL Homo sapiens Q13021
Validated Y2H
32296183
Intra
CLDN9 O95484 CYB561 Homo sapiens P49447
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLDN9 Proteins

Cat. No. Product Name Accession Purity
HY-P700407 Claudin-9/CLDN9 Protein-VLP, Human (HEK293, His) O95484 (M1-V217) /

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 116

DFNB116

Deafness, Autosomal Recessive, 116
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Sacrum Chordoma
Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos
Deafness, Autosomal Recessive 29

DFNB29

Autosomal Recessive Nonsyndromic Deafness 29

Autosomal Recessive Deafness 29

Deafness, Autosomal Recessive, 29

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29

Deafness, Autosomal Recessive, Type 29
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Deafness, Autosomal Recessive 49

DFNB49

Autosomal Recessive Nonsyndromic Deafness 49

Autosomal Recessive Deafness 49

Deafness, Autosomal Recessive, 49

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 49

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 49

Deafness, Autosomal Recessive, Type 49
Deafness, Autosomal Recessive 86

DFNB86

Autosomal Recessive Nonsyndromic Deafness 86

Autosomal Recessive Deafness 86

Deafness, Autosomal Recessive, 86

Deafness, Nonsyndromic, Autosomal Recessive, Type 86
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02777 CLDN9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLDN9 VGNC VGNC:27420
Canis familiaris CLDN9 VGNC VGNC:39323
Rattus norvegicus CLDN9 RGD RGD:1308999
Felis catus CLDN9 VGNC VGNC:60939
Mus musculus CLDN9 MGD MGI:1913100
Others CLDN9 NCBI