PDLIM7 - PDZ and LIM domain 7 Gene

Homo sapiens

Also known as LMP1; LMP3

Gene ID: 9260 | Gene type: protein coding

About PDLIM7

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,483,394-177,497,604 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and 7 paralogues. Broad expression in endometrium (RPKM 61.1), prostate (RPKM 52.9) and 22 other tissues.

Summary

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of RET/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

PDLIM7 Products(3)

mRNA	Protein	Name
NM_005451.5	NP_005442.2	PDZ and LIM domain protein 7 isoform 1
NM_203352.3	NP_976227.1	PDZ and LIM domain protein 7 isoform 2
NM_213636.3	NP_998801.1	PDZ and LIM domain protein 7 isoform 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDLIM7 Protein Structure

PDZ

LIM

0
100
200
300
400
457 a.a.

Protein Preferred Names

Protein Names

PDZ and LIM domain protein 7

1110003B01Rik

Related Diseases

Diseases

Alias

Endobronchial Leiomyoma

Larynx Squamous Papilloma

Laryngeal Squamous Cell Papilloma

Lymphoepithelioma-Like Carcinoma

Lymphoepithelial Carcinoma

Nasopharyngeal Type Undifferentiated Carcinoma

Lung Leiomyoma

Pulmonary Leiomyoma

Leiomyoma Of Lung

Pleural Empyema

Empyema	Pyothorax
Empyema, Pleural	Abscess Of Pleural Cavity
Abscess Of Thorax	Empyema Of Pleura
Empyema Of Pleura Without Fistula	Empyema With Fistula
Empyema With No Fistula	Empyema With Pleural Fistula
Empyema Without Mention Of Fistula	Empyema, Chest
Lung Empyema	Pleural Empyema With Fistula
Pleural Empyema With No Fistula	Purulent Pleurisy
Purulent Pleuritis	Thorax Abscess
Pyopneumothorax

Oral Hairy Leukoplakia

Hairy Leukoplakia	Leukoplakia, Hairy
Hairy Leucoplakia

Pfeiffer Syndrome

Infectious Mononucleosis	Acs5
Craniofacial-Skeletal-Dermatologic Dysplasia	Acs V
Noack Syndrome	Gammaherpesviral Mononucleosis
Acrocephalosyndactyly Type 5	Pfeiffer Syndrome Type 3
Acrocephalosyndactyly, Type V	Glandular Fever
Pfeiffer Type Acrocephalosyndactyly	Pfeiffer Syndrome Type 2
Acrocephalosyndactylia Type V	Filatov'S Disease
Monocytic Angina	Mononucleosis
Pfeiffer'S Disease	Acsv
Acrocephalosyndactyly, Type 5	Craniofacial-Skeletal-Dermatologic Syndrome
Pfeiffer Syndrome Type 1	Classic Pfeiffer Syndrome
PS	Pfeiffer Syndrome Variant
Dysplasia, Craniofacial-Skeletal-Dermatologic	Pfeiffer
Kissing Disease	Infectious Adenitis
Pfeiffer Disease

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm	Neoplasm Of Mature B-Cells
Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10284	PDLIM7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDLIM7	MGD	MGI:1914649
Bos taurus	PDLIM7	VGNC	VGNC:32712
Felis catus	PDLIM7	VGNC	VGNC:64093
Macaca mulatta	PDLIM7	VGNC	VGNC:75848
Rattus norvegicus	PDLIM7	RGD	RGD:628769

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