CYTIP - cytohesin 1 interacting protein Gene

Homo sapiens

Also known as HE; B3-1; CASP; CYBR; CYTHIP; PSCDBP

Gene ID: 9595 | Gene type: protein coding

About CYTIP

Cytogenetic location: 2q24.1 Genomic coordinates (GRCh38): 2:157,414,619-157,444,089 (from NCBI)

This gene has 8 transcripts (splice variants), 200 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 28.7), bone marrow (RPKM 27.5) and 11 other tissues.

Summary

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]

CYTIP Products(1)

mRNA	Protein	Name
NM_004288.5	NP_004279.3	cytohesin-interacting protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11867758	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within regulation of cell adhesion	IDA IDA: Inferred from direct assay	12606567	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	12606567	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12606567	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYTIP Protein Structure

PDZ

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

cytohesin-interacting protein

cbp HE

CYTIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CYTIP	O60759	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	CYTIP	O60759	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	CYTIP	O60759	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	CYTIP	O60759	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	CYTIP	O60759	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	CYTIP	O60759	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	CYTIP	O60759	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	CYTIP	O60759	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	CYTIP	O60759	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183
Intra	CYTIP	O60759	CYTH1	Homo sapiens	Q15438	Anti Tag CoIP	11867758
Intra	CYTIP	O60759	CYTH1	Homo sapiens	Q15438	Y2H Prey Pooling	32296183
Intra	CYTIP	O60759	CYTH1	Homo sapiens	Q15438	Anti Tag CoIP	28514442
Intra	CYTIP	O60759	CYTH1	Homo sapiens	Q15438	Validated Y2H	32296183
Intra	CYTIP	O60759	CYTH1	Homo sapiens	Q15438	Anti Tag CoIP	33961781
Intra	CYTIP	O60759	CYTH1	Homo sapiens	Q15438	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03503	CYTIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CYTIP	MGD	MGI:2183535
Macaca mulatta	CYTIP	VGNC	VGNC:71831
Canis familiaris	CYTIP	VGNC	VGNC:50297
Bos taurus	CYTIP	VGNC	VGNC:49051
Rattus norvegicus	CYTIP	RGD	RGD:1307990
Felis catus	CYTIP	VGNC	VGNC:69098

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