ARHGAP32 - Rho GTPase activating protein 32 Gene

Homo sapiens

Also known as GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP

Gene ID: 9743 | Gene type: protein coding

About ARHGAP32

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:128,965,060-129,279,632 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 12.5), esophagus (RPKM 7.8) and 22 other tissues.

Summary

RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]

ARHGAP32 Products(4)

mRNA	Protein	Name
NM_001142685.2	NP_001136157.1	rho GTPase-activating protein 32 isoform 1
NM_001378024.1	NP_001364953.1	rho GTPase-activating protein 32 isoform 3
NM_001378025.1	NP_001364954.1	rho GTPase-activating protein 32 isoform 4
NM_014715.4	NP_055530.2	rho GTPase-activating protein 32 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12788081	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP32 Protein Structure

SH3_9

RhoGAP

0
400
800
1200
1600
2087 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 32

GAB-associated CDC42

Related Diseases

Diseases

Alias

Subclavian Steal Syndrome

Subclavian Artery Stenosis	Subclavian Steal Phenomenon
Subclavian Steal Steno-Occlusive Disease	Subclavian Steal

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Chromosome 17q23.1-Q23.2 Deletion Syndrome

17q23.1q23.2 Microdeletion Syndrome	17q23.1-Q23.2 Microdeletion Syndrome
Del(17)(Q23.1q23.2)	Monosomy 17q23.1q23.2
Monosomy 17q23.1-Q23.2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00931	ARHGAP32 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARHGAP32	VGNC	VGNC:59889
Bos taurus	ARHGAP32	VGNC	VGNC:26090
Canis familiaris	ARHGAP32	VGNC	VGNC:38059
Rattus norvegicus	ARHGAP32	RGD	RGD:1305267
Macaca mulatta	ARHGAP32	VGNC	VGNC:69855
Mus musculus	ARHGAP32	MGD	MGI:2450166

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