2. Gene
  3. POM121 - POM121 transmembrane nucleoporin Gene

POM121 - POM121 transmembrane nucleoporin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P145; POM121A

Gene ID: 9883 | Gene type: protein coding

About POM121

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:72,879,357-72,951,459 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 16.6), spleen (RPKM 15.4) and 25 other tissues.

Summary

This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

POM121 Products(23)

mRNA Protein Name
NM_001257190.3 NP_001244119.1 nuclear envelope pore membrane protein POM 121 isoform 1
NM_001367610.1 NP_001354539.1 nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387685.1 NP_001374614.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387686.1 NP_001374615.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387687.1 NP_001374616.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387688.1 NP_001374617.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387689.1 NP_001374618.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387691.1 NP_001374620.1 nuclear envelope pore membrane protein POM 121 isoform 4
NM_001387692.1 NP_001374621.1 nuclear envelope pore membrane protein POM 121 isoform 5
NM_001387693.1 NP_001374622.1 nuclear envelope pore membrane protein POM 121 isoform 6
NM_001387694.1 NP_001374623.1 nuclear envelope pore membrane protein POM 121 isoform 7
NM_001387695.1 NP_001374624.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387696.1 NP_001374625.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387697.1 NP_001374626.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387698.1 NP_001374627.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387699.1 NP_001374628.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387700.1 NP_001374629.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387701.1 NP_001374630.1 nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387702.1 NP_001374631.1 nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387703.1 NP_001374632.1 nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387704.1 NP_001374633.1 nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387705.1 NP_001374634.1 nuclear envelope pore membrane protein POM 121 isoform 8
NM_172020.5 NP_742017.1 nuclear envelope pore membrane protein POM 121 isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
24315095 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POM121 Protein Structure

POM121

POM121: POM121 family (316 - 553)

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  • 1249 a.a.
Protein Preferred Names Protein Names

nuclear envelope pore membrane protein POM 121

POM121 membrane glycoprotein

POM121 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
POM121 Q96HA1 PAXIP1 Homo sapiens Q6ZW49-2
Y2H Prey Pooling
25416956
Intra
POM121 Q96HA1 AGR2 Homo sapiens O95994
Y2H Pooling
16189514
Intra
POM121 Q96HA1 RBPMS Homo sapiens Q93062
Y2H Pooling
16189514
Intra
POM121 Q96HA1 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra
POM121 Q96HA1 FXR2 Homo sapiens P51116
Validated Y2H
25416956
Intra
POM121 Q96HA1 TEX11 Homo sapiens Q8IYF3
Y2H Pooling
16189514
Intra
POM121 Q96HA1 TEX11 Homo sapiens Q8IYF3
Y2H Array
25416956
Intra
POM121 Q96HA1 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
25416956
Intra
POM121 Q96HA1 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
25416956
Intra
POM121 Q96HA1 HOMER3 Homo sapiens Q9NSC5
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acute Dacryocystitis

Dacryocystitis - Acute
Trachea Adenoid Cystic Carcinoma

Tracheal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Trachea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10864 POM121 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus POM121 MGD MGI:2137624
Rattus norvegicus POM121 RGD RGD:620680