2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase
  4. GPX4-IN-4

GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer.

For research use only. We do not sell to patients.

GPX4-IN-4 Chemical Structure

GPX4-IN-4 Chemical Structure

CAS No. : 2920221-53-8

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GPX4-IN-4 Related Antibodies

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Description

GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer[1].

IC50 & Target

GPX4[1]
In Vitro

GPX4-IN-4 (Compound 24; 0-1000 nM; 0-24 h) inhibits HT1080 cell viability in a concentration- and time- dependent manner[1].
GPX4-IN-4 (0-10 μM; 72 h) inhibits NCI-H1703 cell viability with EC50s of 0.117 μM and 4.74 μM without and with Fer-1 (HY-100579), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPX4-IN-4 Related Antibodies

Cell Viability Assay[1]

Cell Line: HT1080 (GPX4 dependent) cells
Concentration: 0-1000 nM
Incubation Time: 0, 1.5, 3, 6 and 24 h
Result: Inhibited cell viability with EC50s of 0.85, 0.27, 0.17 and 0.09 μM at 1.5, 3, 6 and 24 h, respectively.

Cell Viability Assay[1]

Cell Line: NCI-H1703
Concentration: 0-10 μM
Incubation Time: 72 h
Result: Inhibited cell viability with EC50s of 0.117 μM and 4.74 μM without and with Fer-1, respectively.
In Vivo

GPX4-IN-4 (Compound 24; 100 and 200 mg/kg; i.p.; once) engages kidney GPX4 and induces PD markers in mice[1].
GPX4-IN-4 (50 mg/kg; i.p.; daily for 20 days) has no effect on WSU-DLCL2 tumor growth in mice, although partial target engagement is observed in tumor homogenate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID/Beige mice[1]
Dosage: 100 and 200 mg/kg
Administration: IP, once
Result: The GPX4 band was shifted. Engaged kidney GPX4 and induced PD markers.
Animal Model: SCID/Beige mice[1]
Dosage: 30 and 100 mg/kg
Administration: IP (Pharmacokinetic Analysis)
Result: PK Properties of GPX4-IN-4 (Compound 24)[1]
Dose t1/2 (h) Cmax (μg/mL) AUC (μg*h/mL)
30 (IP) 0.5 0.92 (±0.24) 1.89 (±0.17)
100 (IP) 1.7 5.31 (±0.53) 16.20 (±1.70)
Molecular Weight

460.93

Formula

C22H21ClN2O5S
CAS No.
SMILES

COC([C@H]1CC2=C([C@@H](N1C(CCl)=O)C3=CC=C(C=C3)S(C)(=O)=O)NC4=CC=CC=C42)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GPX4-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPX4-IN-42920221-53-8Glutathione PeroxidaseHT1080NCI-H1703WSU-DLCL2SCID/Beige miceInhibitorinhibitorinhibit

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