2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK-3β inhibitor 11

GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research.

For research use only. We do not sell to patients.

GSK-3β inhibitor 11 Chemical Structure

GSK-3β inhibitor 11 Chemical Structure

CAS No. : 536731-65-4

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10 mg USD 135 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
100 mg USD 720 In-stock
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Based on 1 publication(s) in Google Scholar

GSK-3β inhibitor 11 Related Antibodies

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Description

GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research[1].

IC50 & Target[1]

GSK-3β

10.02 μM (IC50)

Molecular Weight

393.42

Formula

C20H15N3O4S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C2=C(C(N1CC(NC3=NC(C4=CC(OC)=CC=C4)=CS3)=O)=O)C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (52.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5418 mL 12.7091 mL 25.4181 mL
5 mM 0.5084 mL 2.5418 mL 5.0836 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5418 mL 12.7091 mL 25.4181 mL 63.5453 mL
5 mM 0.5084 mL 2.5418 mL 5.0836 mL 12.7091 mL
10 mM 0.2542 mL 1.2709 mL 2.5418 mL 6.3545 mL
15 mM 0.1695 mL 0.8473 mL 1.6945 mL 4.2364 mL
20 mM 0.1271 mL 0.6355 mL 1.2709 mL 3.1773 mL
25 mM 0.1017 mL 0.5084 mL 1.0167 mL 2.5418 mL
30 mM 0.0847 mL 0.4236 mL 0.8473 mL 2.1182 mL
40 mM 0.0635 mL 0.3177 mL 0.6355 mL 1.5886 mL
50 mM 0.0508 mL 0.2542 mL 0.5084 mL 1.2709 mL
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GSK-3β inhibitor 11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-3β inhibitor 11536731-65-4GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3neurodegenerative diseaseInhibitorinhibitorinhibit

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