hCA/Wnt/β-catenin-IN-1

Cat. No.: HY-155391 Purity: 99.96%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (K_i: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits Wnt/β-catenin signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line.

For research use only. We do not sell to patients.

hCA/Wnt/β-catenin-IN-1 Chemical Structure

CAS No. : 3032826-63-1

Size	Price	Stock	Quantity
5 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 440	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 660	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 998	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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CA CA I CA Ⅱ CA Ⅸ CA XII

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

492.54

Formula

C₂₆H₂₄N₂O₆S

CAS No.

3032826-63-1

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(N2C=C(C3=CC=CC=C3)C(C(C4=CC(OC)=C(OC)C(OC)=C4)=O)=C2)C=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (253.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0303 mL	10.1515 mL	20.3029 mL
5 mM	0.4061 mL	2.0303 mL	4.0606 mL
10 mM	0.2030 mL	1.0151 mL	2.0303 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.96%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (261 KB) HNMR (282 KB) LCMS (109 KB)

Handling Instructions (2659 KB)

References

[1]. Masci D, et al. 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells. J Med Chem. 2023 Oct 30. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0303 mL	10.1515 mL	20.3029 mL	50.7573 mL
	5 mM	0.4061 mL	2.0303 mL	4.0606 mL	10.1515 mL
	10 mM	0.2030 mL	1.0151 mL	2.0303 mL	5.0757 mL
	15 mM	0.1354 mL	0.6768 mL	1.3535 mL	3.3838 mL
	20 mM	0.1015 mL	0.5076 mL	1.0151 mL	2.5379 mL
	25 mM	0.0812 mL	0.4061 mL	0.8121 mL	2.0303 mL
	30 mM	0.0677 mL	0.3384 mL	0.6768 mL	1.6919 mL
	40 mM	0.0508 mL	0.2538 mL	0.5076 mL	1.2689 mL
	50 mM	0.0406 mL	0.2030 mL	0.4061 mL	1.0151 mL
	60 mM	0.0338 mL	0.1692 mL	0.3384 mL	0.8460 mL
	80 mM	0.0254 mL	0.1269 mL	0.2538 mL	0.6345 mL
	100 mM	0.0203 mL	0.1015 mL	0.2030 mL	0.5076 mL