2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. HIF-2α-IN-3

HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent.

For research use only. We do not sell to patients.

HIF-2α-IN-3 Chemical Structure

HIF-2α-IN-3 Chemical Structure

CAS No. : 313964-19-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 385 In-stock
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Solid
5 mg USD 350 In-stock
10 mg USD 550 In-stock
50 mg USD 1650 In-stock
100 mg USD 2250 In-stock
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Based on 1 publication(s) in Google Scholar

HIF-2α-IN-3 Related Antibodies

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Description

HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent[1].

IC50 & Target

IC50: 0.4 µM (HIF-2α)[1]
KD: 1.1 µM (HIF-2α)[1]
In Vitro

HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HIF-2α-IN-3 Related Antibodies
Molecular Weight

335.66

Formula

C12H6ClN5O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=[N+](C1=C(NC2=CC=C(Cl)C([N+]([O-])=O)=C2)C=CC3=NON=C31)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (37.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9792 mL 14.8960 mL 29.7921 mL
5 mM 0.5958 mL 2.9792 mL 5.9584 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9792 mL 14.8960 mL 29.7921 mL 74.4801 mL
5 mM 0.5958 mL 2.9792 mL 5.9584 mL 14.8960 mL
10 mM 0.2979 mL 1.4896 mL 2.9792 mL 7.4480 mL
15 mM 0.1986 mL 0.9931 mL 1.9861 mL 4.9653 mL
20 mM 0.1490 mL 0.7448 mL 1.4896 mL 3.7240 mL
25 mM 0.1192 mL 0.5958 mL 1.1917 mL 2.9792 mL
30 mM 0.0993 mL 0.4965 mL 0.9931 mL 2.4827 mL
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HIF-2α-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIF-2α-IN-3313964-19-1HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHypoxiaproteinligandinteractioncancerInhibitorinhibitorinhibit

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