2. MAPK/ERK Pathway
  3. MAP4K
  4. HPK1-IN-47

HPK1-IN-47 is a PROTAC HPK1 degrader (DC50: 23 nM in PBMCs). HPK1-IN-47 can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-2 (HY-162544). HPK1-IN-47 can be used for research of HPK1-mediated diseases including cancer.

For research use only. We do not sell to patients.

HPK1-IN-47 Chemical Structure

HPK1-IN-47 Chemical Structure

CAS No. : 2893885-42-0

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HPK1-IN-47 Related Antibodies

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MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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Description

HPK1-IN-47 is a PROTAC HPK1 degrader (DC50: 23 nM in PBMCs). HPK1-IN-47 can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-2 (HY-162544). HPK1-IN-47 can be used for research of HPK1-mediated diseases including cancer[1].

Molecular Weight

425.53

Formula

C26H27N5O
CAS No.
SMILES

CC1=C2C(CCNC2)=CC(C3=NC(C(C4=CC=C(C(N(C)C)=O)C(C)=C4)=CN5)=C5N=C3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HPK1-IN-47 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPK1-IN-472893885-42-0MAP4KMAPK Kinase Kinase KinaseInhibitorinhibitorinhibit

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