1. MAPK/ERK Pathway
  2. MAP4K
  3. HPK1-IN-47

HPK1-IN-47 is a PROTAC HPK1 degrader (DC50: 23 nM in PBMCs). HPK1-IN-47 can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-2 (HY-162544). HPK1-IN-47 can be used for research of HPK1-mediated diseases including cancer.

For research use only. We do not sell to patients.

HPK1-IN-47 Chemical Structure

HPK1-IN-47 Chemical Structure

CAS No. : 2893885-42-0

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Description

HPK1-IN-47 is a PROTAC HPK1 degrader (DC50: 23 nM in PBMCs). HPK1-IN-47 can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-2 (HY-162544). HPK1-IN-47 can be used for research of HPK1-mediated diseases including cancer[1].

Molecular Weight

425.53

Formula

C26H27N5O

CAS No.
SMILES

CC1=C2C(CCNC2)=CC(C3=NC(C(C4=CC=C(C(N(C)C)=O)C(C)=C4)=CN5)=C5N=C3)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HPK1-IN-47
Cat. No.:
HY-162545
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