2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. IDH1 Inhibitor 8

IDH1 Inhibitor 8 (91) is isocitrate dehydrogenase 1 (IDH1) inhibitor. IDH1 Inhibitor 8 can be used for the research of cancer.

For research use only. We do not sell to patients.

IDH1 Inhibitor 8 Chemical Structure

IDH1 Inhibitor 8 Chemical Structure

CAS No. : 1448346-63-1

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5 mg USD 90 In-stock
10 mg USD 140 In-stock
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Description

IDH1 Inhibitor 8 (91) is isocitrate dehydrogenase 1 (IDH1) inhibitor. IDH1 Inhibitor 8 can be used for the research of cancer[1].

Molecular Weight

582.96

Formula

C28H22ClF3N6O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1)CC1NC(C(C2=C(C=CC=C2)Cl)N(C3=CN=CC(F)=C3)C([C@H]4N(C5=CC(C#N)=CC=N5)C(CC4)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (171.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7154 mL 8.5769 mL 17.1538 mL
5 mM 0.3431 mL 1.7154 mL 3.4308 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7154 mL 8.5769 mL 17.1538 mL 42.8846 mL
5 mM 0.3431 mL 1.7154 mL 3.4308 mL 8.5769 mL
10 mM 0.1715 mL 0.8577 mL 1.7154 mL 4.2885 mL
15 mM 0.1144 mL 0.5718 mL 1.1436 mL 2.8590 mL
20 mM 0.0858 mL 0.4288 mL 0.8577 mL 2.1442 mL
25 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7154 mL
30 mM 0.0572 mL 0.2859 mL 0.5718 mL 1.4295 mL
40 mM 0.0429 mL 0.2144 mL 0.4288 mL 1.0721 mL
50 mM 0.0343 mL 0.1715 mL 0.3431 mL 0.8577 mL
60 mM 0.0286 mL 0.1429 mL 0.2859 mL 0.7147 mL
80 mM 0.0214 mL 0.1072 mL 0.2144 mL 0.5361 mL
100 mM 0.0172 mL 0.0858 mL 0.1715 mL 0.4288 mL
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IDH1 Inhibitor 8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDH1 Inhibitor 81448346-63-1Isocitrate Dehydrogenase (IDH)isocitrate dehydrogenase 1 (IDH1)cancerInhibitorinhibitorinhibit

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