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  3. Fungal Reactive Oxygen Species Androgen Receptor
  4. Iprodione

Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats.

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Iprodione Chemical Structure

Iprodione Chemical Structure

CAS No. : 36734-19-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

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Iprodione Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats[1][2][3][4][5].

In Vitro

Iprodione (0.75-3 μM) completely inhibits the mycelial growth of Sclerotinia sclerotiorum at a concentration of 3 μM in liquid and solid media with EC50 values of 0.6 and 0.9 μM, respectively[1].
Iprodione (1.5-50 μM; 1-6 days) inhibits the growth of Botrytis cinerea, (5-50; 24 h) inhibits the synthesis of lipids in Botrytis cinerea[2].
Iprodione (0.3-0.4mM; 24 h) produces oxidative damage by increasing free radicals (ROS) in trout hepatocytes and is not species-selective[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Iprodione Related Antibodies
In Vivo

Iprodione (200 mg/kg orally; Once daily for 65 days) reduces sexual activity and fertility in rats[4].
Iprodione (50-200 mg/kg, gavage; Once daily for 30 days) delays pubertal development and inhibits steroidogenesis within the testis in immature male Sprague Dawley rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats model[4]
Dosage: 200 mg/kg
Administration: Oral gavage (p.o.); Once daily for 65 days.
Result: Decreased the gonad index, sperm motility percentage and sperm count in mice.
Reduced serum levels of testosterone, LH, FSH, and E2.
Promoted steroidogenic genes downregulation and suppressed SIRT1/TERT/PGC1α pathway.
Animal Model: Weanling Sprague Dawley rats model[5]
Dosage: 50 mg/kg, 100 mg/kg, 200 mg/kg
Administration: Gavage (i.g.); Once daily for 30 days
Result: Delay PPS at 100 and 200 mg/kg.
Reduced androgen-sensitive seminal vesicle and epididymis weight at 200 mg/kg.
Increased adrenal and liver weight at a dose of 200 mg/kg.
Reduced the production of testosterone and progesterone.
Molecular Weight

330.17

Formula

C13H13Cl2N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C(N1C2=CC(Cl)=CC(Cl)=C2)=O)CC1=O)NC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (302.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0287 mL 15.1437 mL 30.2874 mL
5 mM 0.6057 mL 3.0287 mL 6.0575 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.57 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.57 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0287 mL 15.1437 mL 30.2874 mL 75.7186 mL
5 mM 0.6057 mL 3.0287 mL 6.0575 mL 15.1437 mL
10 mM 0.3029 mL 1.5144 mL 3.0287 mL 7.5719 mL
15 mM 0.2019 mL 1.0096 mL 2.0192 mL 5.0479 mL
20 mM 0.1514 mL 0.7572 mL 1.5144 mL 3.7859 mL
25 mM 0.1211 mL 0.6057 mL 1.2115 mL 3.0287 mL
30 mM 0.1010 mL 0.5048 mL 1.0096 mL 2.5240 mL
40 mM 0.0757 mL 0.3786 mL 0.7572 mL 1.8930 mL
50 mM 0.0606 mL 0.3029 mL 0.6057 mL 1.5144 mL
60 mM 0.0505 mL 0.2524 mL 0.5048 mL 1.2620 mL
80 mM 0.0379 mL 0.1893 mL 0.3786 mL 0.9465 mL
100 mM 0.0303 mL 0.1514 mL 0.3029 mL 0.7572 mL
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Iprodione Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iprodione36734-19-7FungalReactive Oxygen SpeciesAndrogen ReceptorBotrytis cinereaSclerotinia sclerotiorumBactericideInfectionTestosteroneEndocrine disruptionChlorpyrifosMale reproductive toxicitySexual behaviorSteroidogenic genesSIRT1/TERT/PGC-1α pathwayTrout liver cellsROSOxidative stressInhibitorinhibitorinhibit

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