1. PI3K/Akt/mTOR Autophagy Metabolic Enzyme/Protease
  2. PI3K Autophagy Mitophagy Endogenous Metabolite
  3. 3-Methyladenine-d3

3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine[1]. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[2].

For research use only. We do not sell to patients.

3-Methyladenine-d<sub>3</sub> Chemical Structure

3-Methyladenine-d3 Chemical Structure

CAS No. : 110953-39-4

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Based on 1 publication(s) in Google Scholar

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Description

3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine[1]. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

152.17

Formula

C6H4D3N5

CAS No.
Unlabeled CAS

5142-23-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=C2C(N(C=N1)C([2H])([2H])[2H])=NC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (273.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.5716 mL 32.8580 mL 65.7160 mL
5 mM 1.3143 mL 6.5716 mL 13.1432 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.44%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.5716 mL 32.8580 mL 65.7160 mL 164.2899 mL
5 mM 1.3143 mL 6.5716 mL 13.1432 mL 32.8580 mL
10 mM 0.6572 mL 3.2858 mL 6.5716 mL 16.4290 mL
15 mM 0.4381 mL 2.1905 mL 4.3811 mL 10.9527 mL
20 mM 0.3286 mL 1.6429 mL 3.2858 mL 8.2145 mL
25 mM 0.2629 mL 1.3143 mL 2.6286 mL 6.5716 mL
30 mM 0.2191 mL 1.0953 mL 2.1905 mL 5.4763 mL
40 mM 0.1643 mL 0.8214 mL 1.6429 mL 4.1072 mL
50 mM 0.1314 mL 0.6572 mL 1.3143 mL 3.2858 mL
60 mM 0.1095 mL 0.5476 mL 1.0953 mL 2.7382 mL
80 mM 0.0821 mL 0.4107 mL 0.8214 mL 2.0536 mL
100 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.6429 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
3-Methyladenine-d3
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HY-19312S
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