L-Isoleucine-1-¹³C

Name: L-Isoleucine-1- 13 C
Brand: MedChemExpress
SKU: HY-N0771S4
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0771S4 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Isoleucine-1-¹³C is the ¹³C-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid[1]. L-Isoleucine is an essential amino acid.

For research use only. We do not sell to patients.

L-Isoleucine-1-<sup>13</sup>C Chemical Structure

L-Isoleucine-1-¹³C Chemical Structure

CAS No. : 81202-01-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 264	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 264	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Isoleucine-1-¹³C:

L-Isoleucine In-stock

1 Publications Citing Use of MCE L-Isoleucine-1-¹³C

•ACS Chem Biol. 2024 Sep 23. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

L-Isoleucine-1-¹³C is the ¹³C-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid[1]. L-Isoleucine is an essential amino acid.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

132.17

Formula

C₅¹³CH₁₃NO₂

CAS No.

81202-01-9

Unlabeled CAS

73-32-5

Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@H](N)[13C](O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 12.5 mg/mL (94.58 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5660 mL	37.8301 mL	75.6601 mL
5 mM	1.5132 mL	7.5660 mL	15.1320 mL
10 mM	0.7566 mL	3.7830 mL	7.5660 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 25 mg/mL (189.15 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (224 KB) MS (199 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.5660 mL	37.8301 mL	75.6601 mL	189.1503 mL
	5 mM	1.5132 mL	7.5660 mL	15.1320 mL	37.8301 mL
	10 mM	0.7566 mL	3.7830 mL	7.5660 mL	18.9150 mL
	15 mM	0.5044 mL	2.5220 mL	5.0440 mL	12.6100 mL
	20 mM	0.3783 mL	1.8915 mL	3.7830 mL	9.4575 mL
	25 mM	0.3026 mL	1.5132 mL	3.0264 mL	7.5660 mL
	30 mM	0.2522 mL	1.2610 mL	2.5220 mL	6.3050 mL
	40 mM	0.1892 mL	0.9458 mL	1.8915 mL	4.7288 mL
	50 mM	0.1513 mL	0.7566 mL	1.5132 mL	3.7830 mL
	60 mM	0.1261 mL	0.6305 mL	1.2610 mL	3.1525 mL
	80 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3644 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.